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Toll-like receptor 2 drives liver senescence and fibrosis in aging through gut-derived microbial signaling.

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Title: Toll-like receptor 2 drives liver senescence and fibrosis in aging through gut-derived microbial signaling.
Authors: Brandt A; Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria., Staltner R; Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria., Baumann A; Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria., Burger K; Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria., Jelleschitz J; German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany., Prada PO; Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria., Höhn A; German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany., Kopp F; Clinical Pharmacy Group, Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria., Mayneris-Perxachs J; Integrative Systems Medicine and Biology Group, Girona Biomedical Research Institute (IDIBGI-CERCA), Salt, Spain.; CIBER Fisiopatología de La Obesidad y Nutrición (CIBERobn), Madrid, Spain., Fernández-Real JM; Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IDIBGI), Girona, Spain.; CIBERobn Fisiopatología de la Obesidad y Nutrición; and Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain., Bergheim I; Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria. ina.bergheim@univie.ac.at.
Source: Cellular & molecular biology letters [Cell Mol Biol Lett] 2026 Mar 03; Vol. 31 (1). Date of Electronic Publication: 2026 Mar 03.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 9607427 Publication Model: Electronic Cited Medium: Internet ISSN: 1689-1392 (Electronic) Linking ISSN: 14258153 NLM ISO Abbreviation: Cell Mol Biol Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Toll-like receptor 2 drives liver senescence and fibrosis in aging through gut-derived microbial signaling.
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  Data: <searchLink fieldCode="AU" term="%22Brandt+A%22">Brandt A</searchLink>; Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Staltner+R%22">Staltner R</searchLink>; Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Baumann+A%22">Baumann A</searchLink>; Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Burger+K%22">Burger K</searchLink>; Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Jelleschitz+J%22">Jelleschitz J</searchLink>; German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany.<br /><searchLink fieldCode="AU" term="%22Prada+PO%22">Prada PO</searchLink>; Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Höhn+A%22">Höhn A</searchLink>; German Institute of Human Nutrition Potsdam-Rehbrücke (DIfE), Nuthetal, Germany.; German Center for Diabetes Research (DZD), Munich-Neuherberg, Germany.<br /><searchLink fieldCode="AU" term="%22Kopp+F%22">Kopp F</searchLink>; Clinical Pharmacy Group, Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria.<br /><searchLink fieldCode="AU" term="%22Mayneris-Perxachs+J%22">Mayneris-Perxachs J</searchLink>; Integrative Systems Medicine and Biology Group, Girona Biomedical Research Institute (IDIBGI-CERCA), Salt, Spain.; CIBER Fisiopatología de La Obesidad y Nutrición (CIBERobn), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Fernández-Real+JM%22">Fernández-Real JM</searchLink>; Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IDIBGI), Girona, Spain.; CIBERobn Fisiopatología de la Obesidad y Nutrición; and Department of Medical Sciences, School of Medicine, University of Girona, Girona, Spain.<br /><searchLink fieldCode="AU" term="%22Bergheim+I%22">Bergheim I</searchLink>; Department of Nutritional Sciences, Molecular Nutritional Science, University of Vienna, Vienna, Austria. ina.bergheim@univie.ac.at.
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  Data: <searchLink fieldCode="JN" term="%229607427%22">Cellular & molecular biology letters</searchLink> [Cell Mol Biol Lett] 2026 Mar 03; Vol. 31 (1). <i>Date of Electronic Publication: </i>2026 Mar 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9607427 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1689-1392 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214258153%22">14258153 </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Biol Lett <i>Subsets: </i>MEDLINE
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              Text: 2026 Mar 03
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