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Dapagliflozin Inhibits Thrombin Induced ADAM17 Phosphorylation and Downstream ERK/p-c-Jun-mediated CTGF Induction to Prevent Neointimal Hyperplasia.

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Title: Dapagliflozin Inhibits Thrombin Induced ADAM17 Phosphorylation and Downstream ERK/p-c-Jun-mediated CTGF Induction to Prevent Neointimal Hyperplasia.
Authors: Yen TL; Department of Medical Research, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan.; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, 250, Wu Hsing St., Taipei, 110, Taiwan., Chou PC; Division of Interventional Cardiology, Department of Cardiovascular Center, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan., Tsai CT; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, 7, Chung Shan S. Rd., Taipei City, 100225, C.T.T, Taiwan., Chen YL; Department of Medical Research, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan.; Division of Cardiac Electrophysiology, Department of Cardiovascular Center, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan., Chen CY; Division of General Cardiology, Department of Cardiovascular Center, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan., Chien YF; Department of Internal Medicine, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan., Ko WC; Division of Cardiac Electrophysiology, Department of Cardiovascular Center, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan. wckcgh@ms17.hinet.net.; School of Medicine, College of Medicine, Fu Jen Catholic University, 510, Zhongzheng Rd., Xinzhuang Dist, New Taipei City, 242062, Taiwan. wckcgh@ms17.hinet.net.
Source: Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2026 Aug; Vol. 40 (4), pp. 1403-1417. Date of Electronic Publication: 2026 Mar 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Kluwer Academic For The International Society For Cardiovascular Pharmacotherapy Country of Publication: United States NLM ID: 8712220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7241 (Electronic) Linking ISSN: 09203206 NLM ISO Abbreviation: Cardiovasc Drugs Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Dapagliflozin Inhibits Thrombin Induced ADAM17 Phosphorylation and Downstream ERK/p-c-Jun-mediated CTGF Induction to Prevent Neointimal Hyperplasia.
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  Data: <searchLink fieldCode="AU" term="%22Yen+TL%22">Yen TL</searchLink>; Department of Medical Research, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan.; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, 250, Wu Hsing St., Taipei, 110, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chou+PC%22">Chou PC</searchLink>; Division of Interventional Cardiology, Department of Cardiovascular Center, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan.<br /><searchLink fieldCode="AU" term="%22Tsai+CT%22">Tsai CT</searchLink>; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, 7, Chung Shan S. Rd., Taipei City, 100225, C.T.T, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+YL%22">Chen YL</searchLink>; Department of Medical Research, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan.; Division of Cardiac Electrophysiology, Department of Cardiovascular Center, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chen+CY%22">Chen CY</searchLink>; Division of General Cardiology, Department of Cardiovascular Center, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan.<br /><searchLink fieldCode="AU" term="%22Chien+YF%22">Chien YF</searchLink>; Department of Internal Medicine, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan.<br /><searchLink fieldCode="AU" term="%22Ko+WC%22">Ko WC</searchLink>; Division of Cardiac Electrophysiology, Department of Cardiovascular Center, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan. wckcgh@ms17.hinet.net.; School of Medicine, College of Medicine, Fu Jen Catholic University, 510, Zhongzheng Rd., Xinzhuang Dist, New Taipei City, 242062, Taiwan. wckcgh@ms17.hinet.net.
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  Data: <searchLink fieldCode="JN" term="%228712220%22">Cardiovascular drugs and therapy</searchLink> [Cardiovasc Drugs Ther] 2026 Aug; Vol. 40 (4), pp. 1403-1417. <i>Date of Electronic Publication: </i>2026 Mar 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Kluwer+Academic+For+The+International+Society+For+Cardiovascular+Pharmacotherapy%22">Kluwer Academic For The International Society For Cardiovascular Pharmacotherapy </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8712220 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-7241 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209203206%22">09203206 </searchLink><i>NLM ISO Abbreviation: </i>Cardiovasc Drugs Ther <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s10557-026-07857-8
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        Text: English
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      – TitleFull: Dapagliflozin Inhibits Thrombin Induced ADAM17 Phosphorylation and Downstream ERK/p-c-Jun-mediated CTGF Induction to Prevent Neointimal Hyperplasia.
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            – D: 01
              M: 08
              Text: 2026 Aug
              Type: published
              Y: 2026
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