Dapagliflozin Inhibits Thrombin Induced ADAM17 Phosphorylation and Downstream ERK/p-c-Jun-mediated CTGF Induction to Prevent Neointimal Hyperplasia.

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Title: Dapagliflozin Inhibits Thrombin Induced ADAM17 Phosphorylation and Downstream ERK/p-c-Jun-mediated CTGF Induction to Prevent Neointimal Hyperplasia.
Authors: Yen TL; Department of Medical Research, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan.; Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, 250, Wu Hsing St., Taipei, 110, Taiwan., Chou PC; Division of Interventional Cardiology, Department of Cardiovascular Center, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan., Tsai CT; Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, 7, Chung Shan S. Rd., Taipei City, 100225, C.T.T, Taiwan., Chen YL; Department of Medical Research, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan.; Division of Cardiac Electrophysiology, Department of Cardiovascular Center, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan., Chen CY; Division of General Cardiology, Department of Cardiovascular Center, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan., Chien YF; Department of Internal Medicine, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan., Ko WC; Division of Cardiac Electrophysiology, Department of Cardiovascular Center, Cathay General Hospital, 280 Renai Rd. Sec.4, Taipei City, 10630, Taiwan. wckcgh@ms17.hinet.net.; School of Medicine, College of Medicine, Fu Jen Catholic University, 510, Zhongzheng Rd., Xinzhuang Dist, New Taipei City, 242062, Taiwan. wckcgh@ms17.hinet.net.
Source: Cardiovascular drugs and therapy [Cardiovasc Drugs Ther] 2026 Aug; Vol. 40 (4), pp. 1403-1417. Date of Electronic Publication: 2026 Mar 03.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Kluwer Academic For The International Society For Cardiovascular Pharmacotherapy Country of Publication: United States NLM ID: 8712220 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7241 (Electronic) Linking ISSN: 09203206 NLM ISO Abbreviation: Cardiovasc Drugs Ther Subsets: MEDLINE
Database: MEDLINE Ultimate
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