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Neuroprotective, cognitive, and immunomodulatory effects of Valproic acid combined with dextromethorphan in bipolar disorder.

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Title: Neuroprotective, cognitive, and immunomodulatory effects of Valproic acid combined with dextromethorphan in bipolar disorder.
Authors: Huang CC; Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Douliu Branch, Yunlin, Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: huangchihchung@gmail.com., Tzeng NS; Department of Psychiatry, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan; Student Counseling Center, National Defense Medical University, Taipei, Taiwan. Electronic address: pierrens@mail.ndmctsgh.edu.tw., Chang YH; Institute of Gerontology, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Psychology, National Cheng Kung University, Tainan, Taiwan; Department of Neurology, Alzheimer's Disease Research Council (ADRC), National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, Taiwan. Electronic address: yh.chang.snoopy@gmail.com., Hong JS; Neurobiology Laboratory, NIH/NIEHS, Research Triangle Park, NC, USA. Electronic address: hong3@niehs.nih.gov., Lu RB; Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Beijing YiNing Hospital, No.9 Minzhuang Road, Haidian District, Beijing, 100195, China. Electronic address: rblu@mail.ncku.edu.tw.
Source: Journal of psychiatric research [J Psychiatr Res] 2026 Jun; Vol. 197, pp. 118-124. Date of Electronic Publication: 2026 Feb 25.
Publication Type: Journal Article; Randomized Controlled Trial
Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0376331 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1379 (Electronic) Linking ISSN: 00223956 NLM ISO Abbreviation: J Psychiatr Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Neuroprotective, cognitive, and immunomodulatory effects of Valproic acid combined with dextromethorphan in bipolar disorder.
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  Data: <searchLink fieldCode="AU" term="%22Huang+CC%22">Huang CC</searchLink>; Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Douliu Branch, Yunlin, Taiwan; Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. Electronic address: huangchihchung@gmail.com.<br /><searchLink fieldCode="AU" term="%22Tzeng+NS%22">Tzeng NS</searchLink>; Department of Psychiatry, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan; Student Counseling Center, National Defense Medical University, Taipei, Taiwan. Electronic address: pierrens@mail.ndmctsgh.edu.tw.<br /><searchLink fieldCode="AU" term="%22Chang+YH%22">Chang YH</searchLink>; Institute of Gerontology, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Department of Psychology, National Cheng Kung University, Tainan, Taiwan; Department of Neurology, Alzheimer's Disease Research Council (ADRC), National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Graduate Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, Taiwan. Electronic address: yh.chang.snoopy@gmail.com.<br /><searchLink fieldCode="AU" term="%22Hong+JS%22">Hong JS</searchLink>; Neurobiology Laboratory, NIH/NIEHS, Research Triangle Park, NC, USA. Electronic address: hong3@niehs.nih.gov.<br /><searchLink fieldCode="AU" term="%22Lu+RB%22">Lu RB</searchLink>; Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Beijing YiNing Hospital, No.9 Minzhuang Road, Haidian District, Beijing, 100195, China. Electronic address: rblu@mail.ncku.edu.tw.
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  Data: <searchLink fieldCode="JN" term="%220376331%22">Journal of psychiatric research</searchLink> [J Psychiatr Res] 2026 Jun; Vol. 197, pp. 118-124. <i>Date of Electronic Publication: </i>2026 Feb 25.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Pergamon+Press%22">Pergamon Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0376331 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1879-1379 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200223956%22">00223956 </searchLink><i>NLM ISO Abbreviation: </i>J Psychiatr Res <i>Subsets: </i>MEDLINE
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      – Type: doi
        Value: 10.1016/j.jpsychires.2026.02.038
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      – Code: eng
        Text: English
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        StartPage: 118
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      – TitleFull: Neuroprotective, cognitive, and immunomodulatory effects of Valproic acid combined with dextromethorphan in bipolar disorder.
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            NameFull: Huang CC
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            NameFull: Tzeng NS
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            NameFull: Chang YH
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            NameFull: Hong JS
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            – D: 01
              M: 06
              Text: 2026 Jun
              Type: published
              Y: 2026
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              Value: 1879-1379
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              Value: 197
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            – TitleFull: Journal of psychiatric research
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