Senescent epithelial cells remodel the tumor microenvironment and drive early LUAD progression: a multiomics risk model and single-cell analysis.
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| Title: | Senescent epithelial cells remodel the tumor microenvironment and drive early LUAD progression: a multiomics risk model and single-cell analysis. |
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| Authors: | Zhou Y; Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China.; The Second Clinical Medical School of Nanjing Medical University, Nanjing, China., Chen C; Department of Oncology, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China. chenchen881021@njmu.edu.cn.; Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, Jiangsu, China. chenchen881021@njmu.edu.cn., Zuo F; The Second Clinical Medical School of Nanjing Medical University, Nanjing, China., Ding S; Department of Medical Imaging, Nanjing Medical University, Nanjing, Jiangsu, China., Wang H; Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China.; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, China.; The Fourth Clinical College of Nanjing Medical University, Nanjing, China., Xu X; Department of Pathology, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China., Zhu B; Hospital Development Management Office, Nanjing Medical University, Nanjing, China., Wu B; The Second Clinical Medical School of Nanjing Medical University, Nanjing, China., Liu C; The First Clinical Medical College of Nanjing Medical University, Nanjing Medical University, Nanjing, China., Yuan T; The Second Clinical Medical School of Nanjing Medical University, Nanjing, China., Ma D; Department of Pathology, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China. madawei2016@njmu.edu.cn., Huang X; Department of Pathology, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China. polofly2012@njmu.edu.cn. |
| Source: | Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Mar 03; Vol. 83 (1). Date of Electronic Publication: 2026 Mar 03. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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| ISSN: | 1420-9071 |
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| DOI: | 10.1007/s00018-026-06101-8 |
