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Senescent epithelial cells remodel the tumor microenvironment and drive early LUAD progression: a multiomics risk model and single-cell analysis.

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Title: Senescent epithelial cells remodel the tumor microenvironment and drive early LUAD progression: a multiomics risk model and single-cell analysis.
Authors: Zhou Y; Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China.; The Second Clinical Medical School of Nanjing Medical University, Nanjing, China., Chen C; Department of Oncology, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China. chenchen881021@njmu.edu.cn.; Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, Jiangsu, China. chenchen881021@njmu.edu.cn., Zuo F; The Second Clinical Medical School of Nanjing Medical University, Nanjing, China., Ding S; Department of Medical Imaging, Nanjing Medical University, Nanjing, Jiangsu, China., Wang H; Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China.; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, China.; The Fourth Clinical College of Nanjing Medical University, Nanjing, China., Xu X; Department of Pathology, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China., Zhu B; Hospital Development Management Office, Nanjing Medical University, Nanjing, China., Wu B; The Second Clinical Medical School of Nanjing Medical University, Nanjing, China., Liu C; The First Clinical Medical College of Nanjing Medical University, Nanjing Medical University, Nanjing, China., Yuan T; The Second Clinical Medical School of Nanjing Medical University, Nanjing, China., Ma D; Department of Pathology, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China. madawei2016@njmu.edu.cn., Huang X; Department of Pathology, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China. polofly2012@njmu.edu.cn.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Mar 03; Vol. 83 (1). Date of Electronic Publication: 2026 Mar 03.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Senescent epithelial cells remodel the tumor microenvironment and drive early LUAD progression: a multiomics risk model and single-cell analysis.
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  Data: <searchLink fieldCode="AU" term="%22Zhou+Y%22">Zhou Y</searchLink>; Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China.; The Second Clinical Medical School of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Chen+C%22">Chen C</searchLink>; Department of Oncology, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China. chenchen881021@njmu.edu.cn.; Department of Oncology, The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, Jiangsu, China. chenchen881021@njmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Zuo+F%22">Zuo F</searchLink>; The Second Clinical Medical School of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Ding+S%22">Ding S</searchLink>; Department of Medical Imaging, Nanjing Medical University, Nanjing, Jiangsu, China.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China.; Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, China.; The Fourth Clinical College of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Xu+X%22">Xu X</searchLink>; Department of Pathology, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China.<br /><searchLink fieldCode="AU" term="%22Zhu+B%22">Zhu B</searchLink>; Hospital Development Management Office, Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Wu+B%22">Wu B</searchLink>; The Second Clinical Medical School of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Liu+C%22">Liu C</searchLink>; The First Clinical Medical College of Nanjing Medical University, Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Yuan+T%22">Yuan T</searchLink>; The Second Clinical Medical School of Nanjing Medical University, Nanjing, China.<br /><searchLink fieldCode="AU" term="%22Ma+D%22">Ma D</searchLink>; Department of Pathology, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China. madawei2016@njmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Huang+X%22">Huang X</searchLink>; Department of Pathology, Nanjing Medical University Affiliated Cancer Hospital & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, 210009, China. polofly2012@njmu.edu.cn.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9705402 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1420-9071 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221420682X%22">1420682X </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Life Sci <i>Subsets: </i>MEDLINE
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              Text: 2026 Mar 03
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