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Patient-derived complex organoids are a critical tool to understand and explore pediatric malignant brain tumors.

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Title: Patient-derived complex organoids are a critical tool to understand and explore pediatric malignant brain tumors.
Authors: Deschuyter M; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France. deschuyter@unistra.fr.; UMR CNRS 7021, Laboratory of Bioimaging and Pathologies, Translational, Transversal and Therapeutic Oncology Team, OnKO-3T, Faculty of Pharmacy, Illkirch, France. deschuyter@unistra.fr., Martin S; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; UMR CNRS 7021, Laboratory of Bioimaging and Pathologies, Translational, Transversal and Therapeutic Oncology Team, OnKO-3T, Faculty of Pharmacy, Illkirch, France., Salmanli C; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; UMR CNRS 7021, Laboratory of Bioimaging and Pathologies, Translational, Transversal and Therapeutic Oncology Team, OnKO-3T, Faculty of Pharmacy, Illkirch, France., Hubsch C; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; UMR CNRS 7021, Laboratory of Bioimaging and Pathologies, Translational, Transversal and Therapeutic Oncology Team, OnKO-3T, Faculty of Pharmacy, Illkirch, France., Vincent A; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; OrgaRes Platform, Lille, France.; University of Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille, France., Meignan S; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; University of Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille, France.; Tumorigenesis and Resistance to Treatment Unit, Centre Oscar Lambret, Lille, France., Furlan A; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; University of Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille, France.; Tumorigenesis and Resistance to Treatment Unit, Centre Oscar Lambret, Lille, France., Cosset E; GLIMMER Of lIght (GLIoblastoma MetabolisM, HetERogeneity, and OrganoIds), Cancer Research Centre of Lyon, INSERM U1052, CNRS UMR 5286, Lyon, France., Burckel H; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; Radiobiology Laboratory, Institut Strauss, Unicancer, Strasbourg, France.; CNRS ICube UMR 7357, University of Strasbourg, Strasbourg, France., Noel G; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; Radiobiology Laboratory, Institut Strauss, Unicancer, Strasbourg, France.; CNRS ICube UMR 7357, University of Strasbourg, Strasbourg, France., Salzet M; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; Laboratory PRISM-U1192, University of Lille, Lille, France., Duhamel M; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; Laboratory PRISM-U1192, University of Lille, Lille, France., Raffo-Romero A; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; Laboratory PRISM-U1192, University of Lille, Lille, France., Boura C; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; CRAN UMR 7039 UL, CNRS, Département BioSiS, Vandoeuvre Les Nancy, France., Pinel S; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; CRAN UMR 7039 UL, CNRS, Département BioSiS, Vandoeuvre Les Nancy, France., Coca A; Neurosurgery Department, University Hospitals of Strasbourg, Strasbourg, France., Joud A; Neurosurgery Department, University Hospital of Nancy, Vandoeuvre Les Nancy, France., Karnoub MA; Neurosurgery Department, University Hospital of Lille, Lille, France., Chastagner P; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; CRAN UMR 7039 UL, CNRS, Département BioSiS, Vandoeuvre Les Nancy, France.; Pediatric Onco-Hematology Department, University Hospital of Nancy, Vandoeuvre Les Nancy, France., Raimbault S; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; Pediatric Oncology, Centre Oscar Lambret, Lille, France., Sudour-Bonnange H; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; Pediatric Oncology, Centre Oscar Lambret, Lille, France., Flacher V; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; CNRS UPR3572, Laboratory I2CT, Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Moléculaire et Cellulaire (IBMC), Strasbourg, France., Bernhard C; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France., Entz-Werlé N; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France. Natacha.entz-werle@chru-strasbourg.fr.; UMR CNRS 7021, Laboratory of Bioimaging and Pathologies, Translational, Transversal and Therapeutic Oncology Team, OnKO-3T, Faculty of Pharmacy, Illkirch, France. Natacha.entz-werle@chru-strasbourg.fr.; Pediatric Onco-Hematology Unit, University Hospitals of Strasbourg, Strasbourg, France. Natacha.entz-werle@chru-strasbourg.fr.
Source: Cancer metastasis reviews [Cancer Metastasis Rev] 2026 Mar 03; Vol. 45 (1). Date of Electronic Publication: 2026 Mar 03.
Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8605731 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7233 (Electronic) Linking ISSN: 01677659 NLM ISO Abbreviation: Cancer Metastasis Rev Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
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PubType: Academic Journal
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Items – Name: Title
  Label: Title
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  Data: Patient-derived complex organoids are a critical tool to understand and explore pediatric malignant brain tumors.
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  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Deschuyter+M%22">Deschuyter M</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France. deschuyter@unistra.fr.; UMR CNRS 7021, Laboratory of Bioimaging and Pathologies, Translational, Transversal and Therapeutic Oncology Team, OnKO-3T, Faculty of Pharmacy, Illkirch, France. deschuyter@unistra.fr.<br /><searchLink fieldCode="AU" term="%22Martin+S%22">Martin S</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; UMR CNRS 7021, Laboratory of Bioimaging and Pathologies, Translational, Transversal and Therapeutic Oncology Team, OnKO-3T, Faculty of Pharmacy, Illkirch, France.<br /><searchLink fieldCode="AU" term="%22Salmanli+C%22">Salmanli C</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; UMR CNRS 7021, Laboratory of Bioimaging and Pathologies, Translational, Transversal and Therapeutic Oncology Team, OnKO-3T, Faculty of Pharmacy, Illkirch, France.<br /><searchLink fieldCode="AU" term="%22Hubsch+C%22">Hubsch C</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; UMR CNRS 7021, Laboratory of Bioimaging and Pathologies, Translational, Transversal and Therapeutic Oncology Team, OnKO-3T, Faculty of Pharmacy, Illkirch, France.<br /><searchLink fieldCode="AU" term="%22Vincent+A%22">Vincent A</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; OrgaRes Platform, Lille, France.; University of Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille, France.<br /><searchLink fieldCode="AU" term="%22Meignan+S%22">Meignan S</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; University of Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille, France.; Tumorigenesis and Resistance to Treatment Unit, Centre Oscar Lambret, Lille, France.<br /><searchLink fieldCode="AU" term="%22Furlan+A%22">Furlan A</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; University of Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277-CANTHER-Cancer Heterogeneity Plasticity and Resistance to Therapies, Lille, France.; Tumorigenesis and Resistance to Treatment Unit, Centre Oscar Lambret, Lille, France.<br /><searchLink fieldCode="AU" term="%22Cosset+E%22">Cosset E</searchLink>; GLIMMER Of lIght (GLIoblastoma MetabolisM, HetERogeneity, and OrganoIds), Cancer Research Centre of Lyon, INSERM U1052, CNRS UMR 5286, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Burckel+H%22">Burckel H</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; Radiobiology Laboratory, Institut Strauss, Unicancer, Strasbourg, France.; CNRS ICube UMR 7357, University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Noel+G%22">Noel G</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; Radiobiology Laboratory, Institut Strauss, Unicancer, Strasbourg, France.; CNRS ICube UMR 7357, University of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Salzet+M%22">Salzet M</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; Laboratory PRISM-U1192, University of Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Duhamel+M%22">Duhamel M</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; Laboratory PRISM-U1192, University of Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Raffo-Romero+A%22">Raffo-Romero A</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; Laboratory PRISM-U1192, University of Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Boura+C%22">Boura C</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; CRAN UMR 7039 UL, CNRS, Département BioSiS, Vandoeuvre Les Nancy, France.<br /><searchLink fieldCode="AU" term="%22Pinel+S%22">Pinel S</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; CRAN UMR 7039 UL, CNRS, Département BioSiS, Vandoeuvre Les Nancy, France.<br /><searchLink fieldCode="AU" term="%22Coca+A%22">Coca A</searchLink>; Neurosurgery Department, University Hospitals of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Joud+A%22">Joud A</searchLink>; Neurosurgery Department, University Hospital of Nancy, Vandoeuvre Les Nancy, France.<br /><searchLink fieldCode="AU" term="%22Karnoub+MA%22">Karnoub MA</searchLink>; Neurosurgery Department, University Hospital of Lille, Lille, France.<br /><searchLink fieldCode="AU" term="%22Chastagner+P%22">Chastagner P</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; CRAN UMR 7039 UL, CNRS, Département BioSiS, Vandoeuvre Les Nancy, France.; Pediatric Onco-Hematology Department, University Hospital of Nancy, Vandoeuvre Les Nancy, France.<br /><searchLink fieldCode="AU" term="%22Raimbault+S%22">Raimbault S</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; Pediatric Oncology, Centre Oscar Lambret, Lille, France.<br /><searchLink fieldCode="AU" term="%22Sudour-Bonnange+H%22">Sudour-Bonnange H</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; Pediatric Oncology, Centre Oscar Lambret, Lille, France.<br /><searchLink fieldCode="AU" term="%22Flacher+V%22">Flacher V</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.; CNRS UPR3572, Laboratory I2CT, Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Moléculaire et Cellulaire (IBMC), Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Bernhard+C%22">Bernhard C</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France.<br /><searchLink fieldCode="AU" term="%22Entz-Werlé+N%22">Entz-Werlé N</searchLink>; EN-HOPE SMART4CBT Research Center, PEDIACRIEX, Lille, Nancy, Strasbourg, University Hospitals of Strasbourg, Strasbourg, France. Natacha.entz-werle@chru-strasbourg.fr.; UMR CNRS 7021, Laboratory of Bioimaging and Pathologies, Translational, Transversal and Therapeutic Oncology Team, OnKO-3T, Faculty of Pharmacy, Illkirch, France. Natacha.entz-werle@chru-strasbourg.fr.; Pediatric Onco-Hematology Unit, University Hospitals of Strasbourg, Strasbourg, France. Natacha.entz-werle@chru-strasbourg.fr.
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