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SPINK2 silencing suppresses leukemic proliferation and restores myeloid commitment via MECOM downregulation in acute myeloid leukaemia.

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Title: SPINK2 silencing suppresses leukemic proliferation and restores myeloid commitment via MECOM downregulation in acute myeloid leukaemia.
Authors: Ventura AB; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Loconte T; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Ahmed A; Department of Bioscience, Biotechnology and Environment, University of Bari 'Aldo Moro', Bari, Italy., Deligio L; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Negri A; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., D'Angelo G; Department of Interdisciplinary Medicine, University of Bari 'Aldo Moro', Bari, Italy., Di Molfetta D; Department of Bioscience, Biotechnology and Environment, University of Bari 'Aldo Moro', Bari, Italy., Cauchy P; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany., Mandriani B; Experimental Pharmacology Unit, Istituto Nazionale Tumori Fondazione G. Pascale - IRCCS, Naples, Italy., Zhang X; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis and College of Veterinary Medicine, Jilin University, Changchun, China., Pasciolla C; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Rana A; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Iacobazzi A; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Loseto G; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Cives M; Department of Interdisciplinary Medicine, University of Bari 'Aldo Moro', Bari, Italy., Viggiano L; Department of Bioscience, Biotechnology and Environment, University of Bari 'Aldo Moro', Bari, Italy., Lasorsa FM; Department of Bioscience, Biotechnology and Environment, University of Bari 'Aldo Moro', Bari, Italy., Guarini A; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Vegliante MC; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Ciavarella S; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy., Castellano G; SJD Pediatric Cancer Center Barcelona, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.; Hematology Section, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy., Fiermonte G; Department of Bioscience, Biotechnology and Environment, University of Bari 'Aldo Moro', Bari, Italy., Volpe G; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy. g.volpe@oncologico.bari.it.; Department of Pharmacy - Pharmaceutical Sciences, University of Bari 'Aldo Moro', Bari, Italy. g.volpe@oncologico.bari.it.
Source: Cell death discovery [Cell Death Discov] 2026 Mar 03; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 03.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: SPINK2 silencing suppresses leukemic proliferation and restores myeloid commitment via MECOM downregulation in acute myeloid leukaemia.
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  Data: <searchLink fieldCode="AU" term="%22Ventura+AB%22">Ventura AB</searchLink>; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Loconte+T%22">Loconte T</searchLink>; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Ahmed+A%22">Ahmed A</searchLink>; Department of Bioscience, Biotechnology and Environment, University of Bari 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Deligio+L%22">Deligio L</searchLink>; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Negri+A%22">Negri A</searchLink>; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22D'Angelo+G%22">D'Angelo G</searchLink>; Department of Interdisciplinary Medicine, University of Bari 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Di+Molfetta+D%22">Di Molfetta D</searchLink>; Department of Bioscience, Biotechnology and Environment, University of Bari 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Cauchy+P%22">Cauchy P</searchLink>; Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.<br /><searchLink fieldCode="AU" term="%22Mandriani+B%22">Mandriani B</searchLink>; Experimental Pharmacology Unit, Istituto Nazionale Tumori Fondazione G. Pascale - IRCCS, Naples, Italy.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis and College of Veterinary Medicine, Jilin University, Changchun, China.<br /><searchLink fieldCode="AU" term="%22Pasciolla+C%22">Pasciolla C</searchLink>; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Rana+A%22">Rana A</searchLink>; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Iacobazzi+A%22">Iacobazzi A</searchLink>; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Loseto+G%22">Loseto G</searchLink>; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Cives+M%22">Cives M</searchLink>; Department of Interdisciplinary Medicine, University of Bari 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Viggiano+L%22">Viggiano L</searchLink>; Department of Bioscience, Biotechnology and Environment, University of Bari 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Lasorsa+FM%22">Lasorsa FM</searchLink>; Department of Bioscience, Biotechnology and Environment, University of Bari 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Guarini+A%22">Guarini A</searchLink>; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Vegliante+MC%22">Vegliante MC</searchLink>; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Ciavarella+S%22">Ciavarella S</searchLink>; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Castellano+G%22">Castellano G</searchLink>; SJD Pediatric Cancer Center Barcelona, Institut de Recerca Sant Joan de Déu (IRSJD), Esplugues de Llobregat, Barcelona, Spain.; Hematology Section, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy.<br /><searchLink fieldCode="AU" term="%22Fiermonte+G%22">Fiermonte G</searchLink>; Department of Bioscience, Biotechnology and Environment, University of Bari 'Aldo Moro', Bari, Italy.<br /><searchLink fieldCode="AU" term="%22Volpe+G%22">Volpe G</searchLink>; Hematology and Cell Therapy Unit, IRCCS Istituto Tumori 'Giovanni Paolo II', Bari, Italy. g.volpe@oncologico.bari.it.; Department of Pharmacy - Pharmaceutical Sciences, University of Bari 'Aldo Moro', Bari, Italy. g.volpe@oncologico.bari.it.
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  Data: <searchLink fieldCode="JN" term="%22101665035%22">Cell death discovery</searchLink> [Cell Death Discov] 2026 Mar 03; Vol. 12 (1). <i>Date of Electronic Publication: </i>2026 Mar 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101665035 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2058-7716 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220587716%22">20587716 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Discov <i>Subsets: </i>PubMed not MEDLINE
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              Text: 2026 Mar 03
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