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Long term safety and efficacy of a functionalized nanogel with endothelin-1 and bradykinin receptor antagonist peptides for treatment of osteoarthritis of the metacarpophalangeal and distal interphalangeal joints in horses: a descriptive clinical pilot study.

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Title: Long term safety and efficacy of a functionalized nanogel with endothelin-1 and bradykinin receptor antagonist peptides for treatment of osteoarthritis of the metacarpophalangeal and distal interphalangeal joints in horses: a descriptive clinical pilot study.
Authors: Terlinden A; Ecole Nationale Vétérinaire d'Alfort, ACAP3, Goustranville, F-14430, France.; Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, 94700, France., Jacquet S; Ecole Nationale Vétérinaire d'Alfort, ACAP3, Goustranville, F-14430, France.; Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, 94700, France., Manivong S; Centre Hospitalier Universitaire Sainte Justine, Université de Montréal, Montréal, QC, H3T 1C5, Canada.; Faculty of Dentistry, Université de Montréal, Montréal, QC, H3T 1J4, Canada.; Faculty of Pharmacy, Université de Montréal, Montréal, QC, H3T 1J4, Canada., Coudry V; Ecole Nationale Vétérinaire d'Alfort, ACAP3, Goustranville, F-14430, France.; Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, 94700, France., Tallaj A; Ecole Nationale Vétérinaire d'Alfort, ACAP3, Goustranville, F-14430, France.; Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, 94700, France., Cullier A; Université Caen Normandie, Normandie Univ, BIOTARGEN UR7450, Normandie Equine Vallée, GIS CENTAURE, Caen, F-14000, France., Legendre F; Université Caen Normandie, Normandie Univ, BIOTARGEN UR7450, Normandie Equine Vallée, GIS CENTAURE, Caen, F-14000, France., Garcia AA; Faculty of Pharmacy, Université de Montréal, Montréal, QC, H3T 1J4, Canada.; TransMedTech Institute (NanoBio Technology Platform), Montréal, QC, H3T 1J4, Canada., Moldovan F; Centre Hospitalier Universitaire Sainte Justine, Université de Montréal, Montréal, QC, H3T 1C5, Canada.; Faculty of Dentistry, Université de Montréal, Montréal, QC, H3T 1J4, Canada., Sirois P; Faculty of Medicine, Université Laval, Quebec City, QC, G1V 4G2, Canada., Banquy X; Faculty of Pharmacy, Université de Montréal, Montréal, QC, H3T 1J4, Canada., Galéra P; Université Caen Normandie, Normandie Univ, BIOTARGEN UR7450, Normandie Equine Vallée, GIS CENTAURE, Caen, F-14000, France., Audigié F; Ecole Nationale Vétérinaire d'Alfort, ACAP3, Goustranville, F-14430, France.; Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, 94700, France., Roullin G; Faculty of Pharmacy, Université de Montréal, Montréal, QC, H3T 1J4, Canada., Demoor M; Université Caen Normandie, Normandie Univ, BIOTARGEN UR7450, Normandie Equine Vallée, GIS CENTAURE, Caen, F-14000, France., Bertoni L; Ecole Nationale Vétérinaire d'Alfort, ACAP3, Goustranville, F-14430, France. lelia.bertoni@vet-alfort.fr.; Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, 94700, France. lelia.bertoni@vet-alfort.fr.
Source: BMC veterinary research [BMC Vet Res] 2026 Mar 03; Vol. 22 (1). Date of Electronic Publication: 2026 Mar 03.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101249759 Publication Model: Electronic Cited Medium: Internet ISSN: 1746-6148 (Electronic) Linking ISSN: 17466148 NLM ISO Abbreviation: BMC Vet Res Subsets: MEDLINE
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  Data: Long term safety and efficacy of a functionalized nanogel with endothelin-1 and bradykinin receptor antagonist peptides for treatment of osteoarthritis of the metacarpophalangeal and distal interphalangeal joints in horses: a descriptive clinical pilot study.
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  Data: <searchLink fieldCode="AU" term="%22Terlinden+A%22">Terlinden A</searchLink>; Ecole Nationale Vétérinaire d'Alfort, ACAP3, Goustranville, F-14430, France.; Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, 94700, France.<br /><searchLink fieldCode="AU" term="%22Jacquet+S%22">Jacquet S</searchLink>; Ecole Nationale Vétérinaire d'Alfort, ACAP3, Goustranville, F-14430, France.; Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, 94700, France.<br /><searchLink fieldCode="AU" term="%22Manivong+S%22">Manivong S</searchLink>; Centre Hospitalier Universitaire Sainte Justine, Université de Montréal, Montréal, QC, H3T 1C5, Canada.; Faculty of Dentistry, Université de Montréal, Montréal, QC, H3T 1J4, Canada.; Faculty of Pharmacy, Université de Montréal, Montréal, QC, H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Coudry+V%22">Coudry V</searchLink>; Ecole Nationale Vétérinaire d'Alfort, ACAP3, Goustranville, F-14430, France.; Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, 94700, France.<br /><searchLink fieldCode="AU" term="%22Tallaj+A%22">Tallaj A</searchLink>; Ecole Nationale Vétérinaire d'Alfort, ACAP3, Goustranville, F-14430, France.; Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, 94700, France.<br /><searchLink fieldCode="AU" term="%22Cullier+A%22">Cullier A</searchLink>; Université Caen Normandie, Normandie Univ, BIOTARGEN UR7450, Normandie Equine Vallée, GIS CENTAURE, Caen, F-14000, France.<br /><searchLink fieldCode="AU" term="%22Legendre+F%22">Legendre F</searchLink>; Université Caen Normandie, Normandie Univ, BIOTARGEN UR7450, Normandie Equine Vallée, GIS CENTAURE, Caen, F-14000, France.<br /><searchLink fieldCode="AU" term="%22Garcia+AA%22">Garcia AA</searchLink>; Faculty of Pharmacy, Université de Montréal, Montréal, QC, H3T 1J4, Canada.; TransMedTech Institute (NanoBio Technology Platform), Montréal, QC, H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Moldovan+F%22">Moldovan F</searchLink>; Centre Hospitalier Universitaire Sainte Justine, Université de Montréal, Montréal, QC, H3T 1C5, Canada.; Faculty of Dentistry, Université de Montréal, Montréal, QC, H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Sirois+P%22">Sirois P</searchLink>; Faculty of Medicine, Université Laval, Quebec City, QC, G1V 4G2, Canada.<br /><searchLink fieldCode="AU" term="%22Banquy+X%22">Banquy X</searchLink>; Faculty of Pharmacy, Université de Montréal, Montréal, QC, H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Galéra+P%22">Galéra P</searchLink>; Université Caen Normandie, Normandie Univ, BIOTARGEN UR7450, Normandie Equine Vallée, GIS CENTAURE, Caen, F-14000, France.<br /><searchLink fieldCode="AU" term="%22Audigié+F%22">Audigié F</searchLink>; Ecole Nationale Vétérinaire d'Alfort, ACAP3, Goustranville, F-14430, France.; Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, 94700, France.<br /><searchLink fieldCode="AU" term="%22Roullin+G%22">Roullin G</searchLink>; Faculty of Pharmacy, Université de Montréal, Montréal, QC, H3T 1J4, Canada.<br /><searchLink fieldCode="AU" term="%22Demoor+M%22">Demoor M</searchLink>; Université Caen Normandie, Normandie Univ, BIOTARGEN UR7450, Normandie Equine Vallée, GIS CENTAURE, Caen, F-14000, France.<br /><searchLink fieldCode="AU" term="%22Bertoni+L%22">Bertoni L</searchLink>; Ecole Nationale Vétérinaire d'Alfort, ACAP3, Goustranville, F-14430, France. lelia.bertoni@vet-alfort.fr.; Ecole Nationale Vétérinaire d'Alfort, Maisons-Alfort, 94700, France. lelia.bertoni@vet-alfort.fr.
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  Data: <searchLink fieldCode="JN" term="%22101249759%22">BMC veterinary research</searchLink> [BMC Vet Res] 2026 Mar 03; Vol. 22 (1). <i>Date of Electronic Publication: </i>2026 Mar 03.
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