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Risks of non-breast, non-ovarian cancers for BRCA1 and BRCA2 pathogenic variant carriers: a prospective cohort study.

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Title: Risks of non-breast, non-ovarian cancers for BRCA1 and BRCA2 pathogenic variant carriers: a prospective cohort study.
Authors: Yang R; Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia.; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China., MacInnis RJ; Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia., Milne RL; Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia., Nguyen-Dumont T; Clinical Genomics, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.; Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, Australia., Maxwell WF; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Genkinger JM; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, USA., Glendon G; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada., Ross EA; Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center-Temple Health, Philadelphia, PA, USA., Andrulis IL; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada., Colonna SV; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA., Daly M; Fox Chase Cancer Center, Philadelphia, PA, USA., John EM; Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Kurian AW; Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA., Terry MB; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, USA.; Silent Spring Institute, Newton, MA, USA., Hopper JL; Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia., Southey MC; Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia., Phillips KA; Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia.; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Department of Oncology, Sir Peter MacCallum, University of Melbourne, Parkville, VIC, Australia., Li S; Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia. shuai.li@unimelb.edu.au.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia. shuai.li@unimelb.edu.au.
Corporate Authors: Kathleen Cuningham Foundation Consortium for Research Into Familial Breast Cancer (kConFab)
Source: BMC medicine [BMC Med] 2026 Mar 04; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 04.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
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  Data: Risks of non-breast, non-ovarian cancers for BRCA1 and BRCA2 pathogenic variant carriers: a prospective cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Yang+R%22">Yang R</searchLink>; Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia.; Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.<br /><searchLink fieldCode="AU" term="%22MacInnis+RJ%22">MacInnis RJ</searchLink>; Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Milne+RL%22">Milne RL</searchLink>; Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Nguyen-Dumont+T%22">Nguyen-Dumont T</searchLink>; Clinical Genomics, School of Translational Medicine, Monash University, Melbourne, VIC, Australia.; Department of Clinical Pathology, The University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Maxwell+WF%22">Maxwell WF</searchLink>; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Genkinger+JM%22">Genkinger JM</searchLink>; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, USA.<br /><searchLink fieldCode="AU" term="%22Glendon+G%22">Glendon G</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Ross+EA%22">Ross EA</searchLink>; Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center-Temple Health, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22Andrulis+IL%22">Andrulis IL</searchLink>; Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Colonna+SV%22">Colonna SV</searchLink>; Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Daly+M%22">Daly M</searchLink>; Fox Chase Cancer Center, Philadelphia, PA, USA.<br /><searchLink fieldCode="AU" term="%22John+EM%22">John EM</searchLink>; Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Kurian+AW%22">Kurian AW</searchLink>; Department of Epidemiology & Population Health, Stanford University School of Medicine, Stanford, CA, USA.; Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.<br /><searchLink fieldCode="AU" term="%22Terry+MB%22">Terry MB</searchLink>; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, USA.; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, USA.; Silent Spring Institute, Newton, MA, USA.<br /><searchLink fieldCode="AU" term="%22Hopper+JL%22">Hopper JL</searchLink>; Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Southey+MC%22">Southey MC</searchLink>; Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia.; Cancer Epidemiology Division, Cancer Council Victoria, East Melbourne, VIC, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Phillips+KA%22">Phillips KA</searchLink>; Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia.; Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.; Department of Oncology, Sir Peter MacCallum, University of Melbourne, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Center for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Carlton, VIC, Australia. shuai.li@unimelb.edu.au.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia. shuai.li@unimelb.edu.au.
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