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Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics.

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Title: Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics.
Authors: Guo F; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China. fhguo@sibs.ac.cn.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China. fhguo@sibs.ac.cn., Sun D; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China., Ding H; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China., Li Y; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China., Yang B; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China., Guo M; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China., Ma Y; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China., Qiao R; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China., Li S; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China., Zhang L; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China., Zhang Q; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China. zhangqing081@sina.com., Zhang M; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China. zhml1119@sina.com.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China. zhml1119@sina.com., Li W; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China. liwen@shsmu.edu.cn.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China. liwen@shsmu.edu.cn.
Source: BMC medicine [BMC Med] 2026 Mar 03; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 03.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics.
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  Data: <searchLink fieldCode="AU" term="%22Guo+F%22">Guo F</searchLink>; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China. fhguo@sibs.ac.cn.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China. fhguo@sibs.ac.cn.<br /><searchLink fieldCode="AU" term="%22Sun+D%22">Sun D</searchLink>; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China.<br /><searchLink fieldCode="AU" term="%22Ding+H%22">Ding H</searchLink>; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China.<br /><searchLink fieldCode="AU" term="%22Yang+B%22">Yang B</searchLink>; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China.<br /><searchLink fieldCode="AU" term="%22Guo+M%22">Guo M</searchLink>; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.<br /><searchLink fieldCode="AU" term="%22Ma+Y%22">Ma Y</searchLink>; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China.<br /><searchLink fieldCode="AU" term="%22Qiao+R%22">Qiao R</searchLink>; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China.<br /><searchLink fieldCode="AU" term="%22Zhang+L%22">Zhang L</searchLink>; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Q%22">Zhang Q</searchLink>; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China. zhangqing081@sina.com.<br /><searchLink fieldCode="AU" term="%22Zhang+M%22">Zhang M</searchLink>; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China. zhml1119@sina.com.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China. zhml1119@sina.com.<br /><searchLink fieldCode="AU" term="%22Li+W%22">Li W</searchLink>; Center for Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, 200030, China. liwen@shsmu.edu.cn.; Shanghai Key Laboratory of Embryo Original Disease, Shanghai, 200030, China. liwen@shsmu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%22101190723%22">BMC medicine</searchLink> [BMC Med] 2026 Mar 03; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Mar 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190723 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1741-7015 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217417015%22">17417015 </searchLink><i>NLM ISO Abbreviation: </i>BMC Med <i>Subsets: </i>MEDLINE
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RecordInfo BibRecord:
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        Value: 10.1186/s12916-026-04757-4
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      – Code: eng
        Text: English
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      – TitleFull: Identification of cryosensitive niches and a targetable FOS/AP‑1 program in the human ovarian cortex by single‑cell and spatial transcriptomics.
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              Text: 2026 Mar 03
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              Y: 2026
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