Low-Dose Sevoflurane Restores Prefrontal Excitatory/Inhibitory Balance and Improves Autism-Like Social Behavior: A Preclinical and Pilot Clinical Study.

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Title: Low-Dose Sevoflurane Restores Prefrontal Excitatory/Inhibitory Balance and Improves Autism-Like Social Behavior: A Preclinical and Pilot Clinical Study.
Authors: Xu H; Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China.; Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, People's Republic of China., Shi Z; Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China., Guo X; Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China., Deng S; Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China., Wu M; Department of Rehabilitation Medicine, Guangdong Women and Children's Hospital, Guangzhou, People's Republic of China., Chen B; Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China., Qin J; Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China., Xu N; Department of Rehabilitation Medicine, Guangdong Women and Children's Hospital, Guangzhou, People's Republic of China., Zhao T; Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China., Chang Y; Department of Rehabilitation Medicine, Guangdong Women and Children's Hospital, Guangzhou, People's Republic of China., Song X; Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China.; Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, People's Republic of China.
Source: Drug design, development and therapy [Drug Des Devel Ther] 2026 Feb 25; Vol. 20, pp. 534484. Date of Electronic Publication: 2026 Feb 25 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Dove Press Limited Country of Publication: New Zealand NLM ID: 101475745 Publication Model: eCollection Cited Medium: Internet ISSN: 1177-8881 (Electronic) Linking ISSN: 11778881 NLM ISO Abbreviation: Drug Des Devel Ther Subsets: MEDLINE
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  Data: Low-Dose Sevoflurane Restores Prefrontal Excitatory/Inhibitory Balance and Improves Autism-Like Social Behavior: A Preclinical and Pilot Clinical Study.
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  Data: <searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China.; Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Shi+Z%22">Shi Z</searchLink>; Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Guo+X%22">Guo X</searchLink>; Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Deng+S%22">Deng S</searchLink>; Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Wu+M%22">Wu M</searchLink>; Department of Rehabilitation Medicine, Guangdong Women and Children's Hospital, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Chen+B%22">Chen B</searchLink>; Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Qin+J%22">Qin J</searchLink>; Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Xu+N%22">Xu N</searchLink>; Department of Rehabilitation Medicine, Guangdong Women and Children's Hospital, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Zhao+T%22">Zhao T</searchLink>; Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Chang+Y%22">Chang Y</searchLink>; Department of Rehabilitation Medicine, Guangdong Women and Children's Hospital, Guangzhou, People's Republic of China.<br /><searchLink fieldCode="AU" term="%22Song+X%22">Song X</searchLink>; Department of Anesthesiology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, People's Republic of China.; Guangdong-Hong Kong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, People's Republic of China.
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  Data: <searchLink fieldCode="JN" term="%22101475745%22">Drug design, development and therapy</searchLink> [Drug Des Devel Ther] 2026 Feb 25; Vol. 20, pp. 534484. <i>Date of Electronic Publication: </i>2026 Feb 25 (<i>Print Publication: </i>2026).
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              Text: 2026 Feb 25
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