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Directed evolution of the pathogenic mold Aspergillus fumigatus reveals novel genes contributing to triazole resistance.

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Title: Directed evolution of the pathogenic mold Aspergillus fumigatus reveals novel genes contributing to triazole resistance.
Authors: Handelman M; Department of Clinical Microbiology and Immunology, Gray School of Medicine, Tel Aviv University, Tel Aviv, Israel., Sarkar A; Department of Clinical Microbiology and Immunology, Gray School of Medicine, Tel Aviv University, Tel Aviv, Israel., Varshavsky A; Department of Clinical Microbiology and Immunology, Gray School of Medicine, Tel Aviv University, Tel Aviv, Israel., Shadkchan Y; Department of Clinical Microbiology and Immunology, Gray School of Medicine, Tel Aviv University, Tel Aviv, Israel., Chen X; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Wright GD; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Delbaje E; Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil., Laflamme B; Department of Molecular Genetics, University of Toronto, , Toronto, Ontario, Canada., Fallah S; Department of Molecular Genetics, University of Toronto, , Toronto, Ontario, Canada., Côté E; Department of Molecular Genetics, University of Toronto, , Toronto, Ontario, Canada., Robbins N; Department of Molecular Genetics, University of Toronto, , Toronto, Ontario, Canada., Fernanda Dos Reis T; Departamento de Bioquímica, Instituto de Química, Universidade Estadual de São Paulo, Araraquara, Brazil., Goldman GH; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.; National Institute of Science and Technology in Human Pathogenic Fungi, São Paulo, Brazil., Cowen LE; Department of Molecular Genetics, University of Toronto, , Toronto, Ontario, Canada., Osherov N; Department of Clinical Microbiology and Immunology, Gray School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2026 Apr; Vol. 70 (4), pp. e0163525. Date of Electronic Publication: 2026 Mar 04.
Publication Type: Journal Article
Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Directed evolution of the pathogenic mold Aspergillus fumigatus reveals novel genes contributing to triazole resistance.
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  Data: <searchLink fieldCode="AU" term="%22Handelman+M%22">Handelman M</searchLink>; Department of Clinical Microbiology and Immunology, Gray School of Medicine, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Sarkar+A%22">Sarkar A</searchLink>; Department of Clinical Microbiology and Immunology, Gray School of Medicine, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Varshavsky+A%22">Varshavsky A</searchLink>; Department of Clinical Microbiology and Immunology, Gray School of Medicine, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Shadkchan+Y%22">Shadkchan Y</searchLink>; Department of Clinical Microbiology and Immunology, Gray School of Medicine, Tel Aviv University, Tel Aviv, Israel.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Wright+GD%22">Wright GD</searchLink>; David Braley Centre for Antibiotics Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Delbaje+E%22">Delbaje E</searchLink>; Departamento de Biologia, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Laflamme+B%22">Laflamme B</searchLink>; Department of Molecular Genetics, University of Toronto, , Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Fallah+S%22">Fallah S</searchLink>; Department of Molecular Genetics, University of Toronto, , Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Côté+E%22">Côté E</searchLink>; Department of Molecular Genetics, University of Toronto, , Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Robbins+N%22">Robbins N</searchLink>; Department of Molecular Genetics, University of Toronto, , Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Fernanda+Dos+Reis+T%22">Fernanda Dos Reis T</searchLink>; Departamento de Bioquímica, Instituto de Química, Universidade Estadual de São Paulo, Araraquara, Brazil.<br /><searchLink fieldCode="AU" term="%22Goldman+GH%22">Goldman GH</searchLink>; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil.; National Institute of Science and Technology in Human Pathogenic Fungi, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Cowen+LE%22">Cowen LE</searchLink>; Department of Molecular Genetics, University of Toronto, , Toronto, Ontario, Canada.<br /><searchLink fieldCode="AU" term="%22Osherov+N%22">Osherov N</searchLink>; Department of Clinical Microbiology and Immunology, Gray School of Medicine, Tel Aviv University, Tel Aviv, Israel.
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              Text: 2026 Apr
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