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Extracellular heme:DNA complexes promote oxidative stress and inflammation during lupus-associated hemolysis.

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Title: Extracellular heme:DNA complexes promote oxidative stress and inflammation during lupus-associated hemolysis.
Authors: Janovicova L; Department of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.; Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava 811 08, Slovakia., Janikova M; Department of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.; Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava 811 08, Slovakia., Pastorek M; Department of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.; Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava 811 08, Slovakia., Csizmadia E; Department of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214., Yoder C; Department of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214., Lesayova A; Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava 811 08, Slovakia., Geyer L; Department of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214., Kyttaris VC; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214., Tsokos GC; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214., Celec P; Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava 811 08, Slovakia., Wegiel B; Department of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.
Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Mar 10; Vol. 123 (10), pp. e2526577123. Date of Electronic Publication: 2026 Mar 04.
Publication Type: Journal Article
Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
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  Data: Extracellular heme:DNA complexes promote oxidative stress and inflammation during lupus-associated hemolysis.
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  Data: <searchLink fieldCode="AU" term="%22Janovicova+L%22">Janovicova L</searchLink>; Department of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.; Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava 811 08, Slovakia.<br /><searchLink fieldCode="AU" term="%22Janikova+M%22">Janikova M</searchLink>; Department of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.; Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava 811 08, Slovakia.<br /><searchLink fieldCode="AU" term="%22Pastorek+M%22">Pastorek M</searchLink>; Department of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.; Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava 811 08, Slovakia.<br /><searchLink fieldCode="AU" term="%22Csizmadia+E%22">Csizmadia E</searchLink>; Department of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.<br /><searchLink fieldCode="AU" term="%22Yoder+C%22">Yoder C</searchLink>; Department of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.<br /><searchLink fieldCode="AU" term="%22Lesayova+A%22">Lesayova A</searchLink>; Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava 811 08, Slovakia.<br /><searchLink fieldCode="AU" term="%22Geyer+L%22">Geyer L</searchLink>; Department of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.<br /><searchLink fieldCode="AU" term="%22Kyttaris+VC%22">Kyttaris VC</searchLink>; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.<br /><searchLink fieldCode="AU" term="%22Tsokos+GC%22">Tsokos GC</searchLink>; Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.<br /><searchLink fieldCode="AU" term="%22Celec+P%22">Celec P</searchLink>; Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava 811 08, Slovakia.<br /><searchLink fieldCode="AU" term="%22Wegiel+B%22">Wegiel B</searchLink>; Department of Surgery, Division of Surgical Sciences, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02214.
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  Data: <searchLink fieldCode="JN" term="%227505876%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink> [Proc Natl Acad Sci U S A] 2026 Mar 10; Vol. 123 (10), pp. e2526577123. <i>Date of Electronic Publication: </i>2026 Mar 04.
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