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A UPLC-MS/MS assay for the quantification of the novel viral helicase-primase drug candidate adibelivir (IM-250) in human specimen.

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Title: A UPLC-MS/MS assay for the quantification of the novel viral helicase-primase drug candidate adibelivir (IM-250) in human specimen.
Authors: Bay C; Heidelberg University, Medical Faculty Heidelberg/Heidelberg University Hospital, Internal Medicine IX, Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany., Bergamino M; Heidelberg University, Medical Faculty Heidelberg/Heidelberg University Hospital, Internal Medicine IX, Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany., Sauter M; Heidelberg University, Medical Faculty Heidelberg/Heidelberg University Hospital, Internal Medicine IX, Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany., Czock D; Heidelberg University, Medical Faculty Heidelberg/Heidelberg University Hospital, Internal Medicine IX, Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany., Gege C; Innovative Molecules GmbH, Lipowsky Str. 10, 81373 Munich, Germany., Blank A; Heidelberg University, Medical Faculty Heidelberg/Heidelberg University Hospital, Internal Medicine IX, Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany., Kleymann G; Innovative Molecules GmbH, Lipowsky Str. 10, 81373 Munich, Germany., Burhenne J; Heidelberg University, Medical Faculty Heidelberg/Heidelberg University Hospital, Internal Medicine IX, Department of Clinical Pharmacology and Pharmacoepidemiology, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany. Electronic address: juergen.burhenne@med.uni-heidelberg.de.
Source: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences [J Chromatogr B Analyt Technol Biomed Life Sci] 2026 May 01; Vol. 1275, pp. 124995. Date of Electronic Publication: 2026 Feb 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139554 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-376X (Electronic) Linking ISSN: 15700232 NLM ISO Abbreviation: J Chromatogr B Analyt Technol Biomed Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: A UPLC-MS/MS assay for the quantification of the novel viral helicase-primase drug candidate adibelivir (IM-250) in human specimen.
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              Text: 2026 May 01
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