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Discovery and characterization of canvuparatide, a once-weekly parathyroid hormone analog for the treatment of hypoparathyroidism.

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Title: Discovery and characterization of canvuparatide, a once-weekly parathyroid hormone analog for the treatment of hypoparathyroidism.
Authors: Zhang F; Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA., Perez-Tilve D; Department of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA., Allen MR; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Metzger CE; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA., Dorato MA; MBX Biosciences, Carmel, IN, 46032, USA., Geiger MJ; MBX Biosciences, Carmel, IN, 46032, USA., DiMarchi RD; Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA; MBX Biosciences, Carmel, IN, 46032, USA. Electronic address: rdimarch@iu.edu.
Source: Molecular metabolism [Mol Metab] 2026 May; Vol. 107, pp. 102345. Date of Electronic Publication: 2026 Mar 02.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier GmbH Country of Publication: Germany NLM ID: 101605730 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-8778 (Electronic) Linking ISSN: 22128778 NLM ISO Abbreviation: Mol Metab Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Zhang+F%22">Zhang F</searchLink>; Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA.<br /><searchLink fieldCode="AU" term="%22Perez-Tilve+D%22">Perez-Tilve D</searchLink>; Department of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.<br /><searchLink fieldCode="AU" term="%22Allen+MR%22">Allen MR</searchLink>; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.<br /><searchLink fieldCode="AU" term="%22Metzger+CE%22">Metzger CE</searchLink>; Department of Anatomy, Cell Biology, and Physiology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.<br /><searchLink fieldCode="AU" term="%22Dorato+MA%22">Dorato MA</searchLink>; MBX Biosciences, Carmel, IN, 46032, USA.<br /><searchLink fieldCode="AU" term="%22Geiger+MJ%22">Geiger MJ</searchLink>; MBX Biosciences, Carmel, IN, 46032, USA.<br /><searchLink fieldCode="AU" term="%22DiMarchi+RD%22">DiMarchi RD</searchLink>; Department of Chemistry, Indiana University, Bloomington, IN, 47405, USA; MBX Biosciences, Carmel, IN, 46032, USA. Electronic address: rdimarch@iu.edu.
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  Data: <searchLink fieldCode="JN" term="%22101605730%22">Molecular metabolism</searchLink> [Mol Metab] 2026 May; Vol. 107, pp. 102345. <i>Date of Electronic Publication: </i>2026 Mar 02.
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        Value: 10.1016/j.molmet.2026.102345
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              Text: 2026 May
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