Phase Ib Study to Assess the Safety of Neoadjuvant Trifluridine/Tipiracil With Concurrent Radiation in Resectable Stage II/III Rectal Cancer: The FIERCE Study.
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| Title: | Phase Ib Study to Assess the Safety of Neoadjuvant Trifluridine/Tipiracil With Concurrent Radiation in Resectable Stage II/III Rectal Cancer: The FIERCE Study. |
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| Authors: | Chen EY; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR. Electronic address: cheem@ohsu.edu., Nabavizadeh N; Department of Radiation Medicine, Oregon Health & Science University, Portland, OR., Kendsersky ND; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR., Lessenich C; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR., Herzig DO; Division of Gastrointestinal and General Surgery, Oregon Health & Science University, Portland, OR., Korngold E; Department of Diagnostic Radiology, Oregon Health & Science University, Portland, OR., Goodyear SM; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR., Kennecke HF; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR., Kardosh A; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR., Tsikitis VL; Division of Gastrointestinal and General Surgery, Oregon Health & Science University, Portland, OR., Lu KC; Division of Gastrointestinal and General Surgery, Oregon Health & Science University, Portland, OR., Fang S; Division of Gastrointestinal and General Surgery, Oregon Health & Science University, Portland, OR., Wong M; Department of Cell, Developmental and Cancer Biology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR., Pegna GJ; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR., Rocha FG; Division of Surgical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR., Mayo SC; Division of Surgical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR., Brinkerhoff B; Department of Pathology, Oregon Health & Science University, Portland, OR., Taber E; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR., Rajagopalan B; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR., Park BS; Biostatistics Shared Resource, OHSU Knight Cancer Institute, OHSU School of Medicine, Portland, OR., Thomas CR Jr; Department of Radiation Oncology & Applied Sciences, Geisel School of Medicine, Hanover, NH., Lopez CD; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR. Electronic address: lopezc@ohsu.edu. |
| Source: | Clinical colorectal cancer [Clin Colorectal Cancer] 2026 Jun; Vol. 25 (2), pp. 249-257.e2. Date of Electronic Publication: 2026 Feb 04. |
| Publication Type: | Journal Article; Clinical Trial, Phase I |
| Journal Info: | Publisher: Elsevier Country of Publication: United States NLM ID: 101120693 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1938-0674 (Electronic) Linking ISSN: 15330028 NLM ISO Abbreviation: Clin Colorectal Cancer Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41781240 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Phase Ib Study to Assess the Safety of Neoadjuvant Trifluridine/Tipiracil With Concurrent Radiation in Resectable Stage II/III Rectal Cancer: The FIERCE Study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Chen+EY%22">Chen EY</searchLink>; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR. Electronic address: cheem@ohsu.edu.<br /><searchLink fieldCode="AU" term="%22Nabavizadeh+N%22">Nabavizadeh N</searchLink>; Department of Radiation Medicine, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Kendsersky+ND%22">Kendsersky ND</searchLink>; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Lessenich+C%22">Lessenich C</searchLink>; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Herzig+DO%22">Herzig DO</searchLink>; Division of Gastrointestinal and General Surgery, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Korngold+E%22">Korngold E</searchLink>; Department of Diagnostic Radiology, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Goodyear+SM%22">Goodyear SM</searchLink>; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Kennecke+HF%22">Kennecke HF</searchLink>; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Kardosh+A%22">Kardosh A</searchLink>; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Tsikitis+VL%22">Tsikitis VL</searchLink>; Division of Gastrointestinal and General Surgery, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Lu+KC%22">Lu KC</searchLink>; Division of Gastrointestinal and General Surgery, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Fang+S%22">Fang S</searchLink>; Division of Gastrointestinal and General Surgery, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Wong+M%22">Wong M</searchLink>; Department of Cell, Developmental and Cancer Biology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Pegna+GJ%22">Pegna GJ</searchLink>; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Rocha+FG%22">Rocha FG</searchLink>; Division of Surgical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Mayo+SC%22">Mayo SC</searchLink>; Division of Surgical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Brinkerhoff+B%22">Brinkerhoff B</searchLink>; Department of Pathology, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Taber+E%22">Taber E</searchLink>; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Rajagopalan+B%22">Rajagopalan B</searchLink>; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Park+BS%22">Park BS</searchLink>; Biostatistics Shared Resource, OHSU Knight Cancer Institute, OHSU School of Medicine, Portland, OR.<br /><searchLink fieldCode="AU" term="%22Thomas+CR+Jr%22">Thomas CR Jr</searchLink>; Department of Radiation Oncology & Applied Sciences, Geisel School of Medicine, Hanover, NH.<br /><searchLink fieldCode="AU" term="%22Lopez+CD%22">Lopez CD</searchLink>; Division of Hematology and Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR. Electronic address: lopezc@ohsu.edu. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101120693%22">Clinical colorectal cancer</searchLink> [Clin Colorectal Cancer] 2026 Jun; Vol. 25 (2), pp. 249-257.e2. <i>Date of Electronic Publication: </i>2026 Feb 04. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article; Clinical Trial, Phase I – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101120693 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1938-0674 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215330028%22">15330028 </searchLink><i>NLM ISO Abbreviation: </i>Clin Colorectal Cancer <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41781240 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.clcc.2026.02.001 Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 249 Titles: – TitleFull: Phase Ib Study to Assess the Safety of Neoadjuvant Trifluridine/Tipiracil With Concurrent Radiation in Resectable Stage II/III Rectal Cancer: The FIERCE Study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Chen EY – PersonEntity: Name: NameFull: Nabavizadeh N – PersonEntity: Name: NameFull: Kendsersky ND – PersonEntity: Name: NameFull: Lessenich C – PersonEntity: Name: NameFull: Herzig DO – PersonEntity: Name: NameFull: Korngold E – PersonEntity: Name: NameFull: Goodyear SM – PersonEntity: Name: NameFull: Kennecke HF – PersonEntity: Name: NameFull: Kardosh A – PersonEntity: Name: NameFull: Tsikitis VL – PersonEntity: Name: NameFull: Lu KC – PersonEntity: Name: NameFull: Fang S – PersonEntity: Name: NameFull: Wong M – PersonEntity: Name: NameFull: Pegna GJ – PersonEntity: Name: NameFull: Rocha FG – PersonEntity: Name: NameFull: Mayo SC – PersonEntity: Name: NameFull: Brinkerhoff B – PersonEntity: Name: NameFull: Taber E – PersonEntity: Name: NameFull: Rajagopalan B – PersonEntity: Name: NameFull: Park BS – PersonEntity: Name: NameFull: Thomas CR Jr – PersonEntity: Name: NameFull: Lopez CD IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: 2026 Jun Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1938-0674 Numbering: – Type: volume Value: 25 – Type: issue Value: 2 Titles: – TitleFull: Clinical colorectal cancer Type: main |
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