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AI-based BRAIx risk score for the intermediate-term prediction of breast cancer: a population cohort study.

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Title: AI-based BRAIx risk score for the intermediate-term prediction of breast cancer: a population cohort study.
Authors: Frazer HML; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia; St Vincent's BreastScreen, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia; Department of Radiology, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia; BreastScreen Victoria, Melbourne, VIC, Australia. Electronic address: helen.frazer@svha.org.au., Hopper JL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia., Nguyen TL; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia., Elliott MS; Bioinformatics and Cellular Genomics Unit, St Vincent's Institute of Medical Research, Melbourne, VIC, Australia; Melbourne Integrative Genomics, School of Mathematics and Statistics and School of BioSciences, Faculty of Science, University of Melbourne, Melbourne, VIC, Australia., Kunicki KM; Bioinformatics and Cellular Genomics Unit, St Vincent's Institute of Medical Research, Melbourne, VIC, Australia., Al-Qershi O; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia., Schmidt DF; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Faculty of Information Technology, Monash University, Clayton, VIC, Australia., Makalic E; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Faculty of Information Technology, Monash University, Clayton, VIC, Australia., Li S; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia., Fox SK; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia., Dowty JG; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia., Peña-Solorzano CA; Bioinformatics and Cellular Genomics Unit, St Vincent's Institute of Medical Research, Melbourne, VIC, Australia; Melbourne Integrative Genomics, School of Mathematics and Statistics and School of BioSciences, Faculty of Science, University of Melbourne, Melbourne, VIC, Australia., Kwok CF; Bioinformatics and Cellular Genomics Unit, St Vincent's Institute of Medical Research, Melbourne, VIC, Australia; Melbourne Integrative Genomics, School of Mathematics and Statistics and School of BioSciences, Faculty of Science, University of Melbourne, Melbourne, VIC, Australia., Chen Y; School of Computer Science, Australian Institute for Machine Learning, University of Adelaide, SA, Australia., Wang C; School of Computer Science, Australian Institute for Machine Learning, University of Adelaide, SA, Australia., Lippey J; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia; St Vincent's BreastScreen, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia; BreastScreen Victoria, Melbourne, VIC, Australia; Department of Surgery, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia., Brotchie P; Department of Radiology, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia., Carneiro G; Centre for Vision, Speech and Signal Processing, University of Surrey, Guildford, UK., Strand F; Breast Radiology Unit, Department of Imaging and Physiology, Karolinska University Hospital, Stockholm, Sweden; Breast Radiology Unit, Medical Diagnostics Karolinska, Karolinska University Hospital, Stockholm, Sweden., McCarthy DJ; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia; Bioinformatics and Cellular Genomics Unit, St Vincent's Institute of Medical Research, Melbourne, VIC, Australia; Melbourne Integrative Genomics, School of Mathematics and Statistics and School of BioSciences, Faculty of Science, University of Melbourne, Melbourne, VIC, Australia. Electronic address: dmccarthy@svi.edu.au.
Source: The Lancet. Digital health [Lancet Digit Health] 2026 Apr; Vol. 8 (4), pp. 100987. Date of Electronic Publication: 2026 Mar 03.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101751302 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2589-7500 (Electronic) Linking ISSN: 25897500 NLM ISO Abbreviation: Lancet Digit Health Subsets: MEDLINE
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  Data: AI-based BRAIx risk score for the intermediate-term prediction of breast cancer: a population cohort study.
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  Data: <searchLink fieldCode="AU" term="%22Frazer+HML%22">Frazer HML</searchLink>; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia; St Vincent's BreastScreen, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia; Department of Radiology, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia; BreastScreen Victoria, Melbourne, VIC, Australia. Electronic address: helen.frazer@svha.org.au.<br /><searchLink fieldCode="AU" term="%22Hopper+JL%22">Hopper JL</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Nguyen+TL%22">Nguyen TL</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Elliott+MS%22">Elliott MS</searchLink>; Bioinformatics and Cellular Genomics Unit, St Vincent's Institute of Medical Research, Melbourne, VIC, Australia; Melbourne Integrative Genomics, School of Mathematics and Statistics and School of BioSciences, Faculty of Science, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Kunicki+KM%22">Kunicki KM</searchLink>; Bioinformatics and Cellular Genomics Unit, St Vincent's Institute of Medical Research, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Al-Qershi+O%22">Al-Qershi O</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Schmidt+DF%22">Schmidt DF</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Faculty of Information Technology, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Makalic+E%22">Makalic E</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Faculty of Information Technology, Monash University, Clayton, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Li+S%22">Li S</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia; Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia; Murdoch Children's Research Institute, Royal Children's Hospital, Parkville, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Fox+SK%22">Fox SK</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Dowty+JG%22">Dowty JG</searchLink>; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Peña-Solorzano+CA%22">Peña-Solorzano CA</searchLink>; Bioinformatics and Cellular Genomics Unit, St Vincent's Institute of Medical Research, Melbourne, VIC, Australia; Melbourne Integrative Genomics, School of Mathematics and Statistics and School of BioSciences, Faculty of Science, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Kwok+CF%22">Kwok CF</searchLink>; Bioinformatics and Cellular Genomics Unit, St Vincent's Institute of Medical Research, Melbourne, VIC, Australia; Melbourne Integrative Genomics, School of Mathematics and Statistics and School of BioSciences, Faculty of Science, University of Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; School of Computer Science, Australian Institute for Machine Learning, University of Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Wang+C%22">Wang C</searchLink>; School of Computer Science, Australian Institute for Machine Learning, University of Adelaide, SA, Australia.<br /><searchLink fieldCode="AU" term="%22Lippey+J%22">Lippey J</searchLink>; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia; St Vincent's BreastScreen, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia; BreastScreen Victoria, Melbourne, VIC, Australia; Department of Surgery, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Brotchie+P%22">Brotchie P</searchLink>; Department of Radiology, St Vincent's Hospital Melbourne, Melbourne, VIC, Australia.<br /><searchLink fieldCode="AU" term="%22Carneiro+G%22">Carneiro G</searchLink>; Centre for Vision, Speech and Signal Processing, University of Surrey, Guildford, UK.<br /><searchLink fieldCode="AU" term="%22Strand+F%22">Strand F</searchLink>; Breast Radiology Unit, Department of Imaging and Physiology, Karolinska University Hospital, Stockholm, Sweden; Breast Radiology Unit, Medical Diagnostics Karolinska, Karolinska University Hospital, Stockholm, Sweden.<br /><searchLink fieldCode="AU" term="%22McCarthy+DJ%22">McCarthy DJ</searchLink>; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia; Bioinformatics and Cellular Genomics Unit, St Vincent's Institute of Medical Research, Melbourne, VIC, Australia; Melbourne Integrative Genomics, School of Mathematics and Statistics and School of BioSciences, Faculty of Science, University of Melbourne, Melbourne, VIC, Australia. Electronic address: dmccarthy@svi.edu.au.
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  Data: <searchLink fieldCode="JN" term="%22101751302%22">The Lancet. Digital health</searchLink> [Lancet Digit Health] 2026 Apr; Vol. 8 (4), pp. 100987. <i>Date of Electronic Publication: </i>2026 Mar 03.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Ltd%22">Elsevier Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101751302 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2589-7500 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2225897500%22">25897500 </searchLink><i>NLM ISO Abbreviation: </i>Lancet Digit Health <i>Subsets: </i>MEDLINE
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