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Precancerous niche remodelling dictates nascent tumour persistence.

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Title: Precancerous niche remodelling dictates nascent tumour persistence.
Authors: Skrupskelyte G; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. gs463@cam.ac.uk.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. gs463@cam.ac.uk., Rojo Arias JE; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; RhyGaze, Basel, Switzerland., Ajith H; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Dang Y; Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany.; Max Planck Institute for the Physics of Complex Systems, Dresden, Germany.; Center for Systems Biology, Dresden, Germany., Rossetti D; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Han S; Gurdon Institute, University of Cambridge, Cambridge, UK., Tang MKS; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Bejar MT; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK., Colom B; Wellcome Sanger Institute, Hinxton, UK.; Cambridge Institute of Science, Altos Labs, Cambridge, UK., Fowler JC; Wellcome Sanger Institute, Hinxton, UK., Murai K; Wellcome Sanger Institute, Hinxton, UK., Knight W; Wellcome Sanger Institute, Hinxton, UK., Aust D; University Hospital Carl Gustav Carus Dresden, Faculty of Medicine of TUD Dresden University of Technology, Dresden, Germany.; Institute of Pathology, University Hospital CGC Dresden, TU Dresden, Dresden, Germany., Schmidt MHH; Institute of Anatomy, Faculty of Medicine of TUD, University of Technology, Dresden, Germany., Jászai J; Institute of Anatomy, Faculty of Medicine of TUD, University of Technology, Dresden, Germany., Zeki S; Department of Gastroenterology, Guy's and St. Thomas' Hospital, London, UK., Noorani A; Wellcome Sanger Institute, Hinxton, UK.; Addenbrooke's Hospital, Cambridge University Hospital NHS Trust, Cambridge, UK., Jones PH; Wellcome Sanger Institute, Hinxton, UK.; Department of Oncology, University of Cambridge, Hutchison Research Centre, Cambridge Biomedical Campus, Cambridge, UK., Rulands S; Max Planck Institute for the Physics of Complex Systems, Dresden, Germany.; Arnold Sommerfeld Center for Theoretical Physics, Ludwigs-Maximilians-Universität Munchen, Munich, Germany., Simons BD; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Gurdon Institute, University of Cambridge, Cambridge, UK.; Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Science, University of Cambridge, Cambridge, UK., Alcolea MP; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. mpa28@cam.ac.uk.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. mpa28@cam.ac.uk.
Source: Nature [Nature] 2026 May; Vol. 653 (8113), pp. 242-253. Date of Electronic Publication: 2026 Mar 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Skrupskelyte+G%22">Skrupskelyte G</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. gs463@cam.ac.uk.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. gs463@cam.ac.uk.<br /><searchLink fieldCode="AU" term="%22Rojo+Arias+JE%22">Rojo Arias JE</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.; RhyGaze, Basel, Switzerland.<br /><searchLink fieldCode="AU" term="%22Ajith+H%22">Ajith H</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Dang+Y%22">Dang Y</searchLink>; Max Planck Institute for Molecular Cell Biology and Genetics, Dresden, Germany.; Max Planck Institute for the Physics of Complex Systems, Dresden, Germany.; Center for Systems Biology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Rossetti+D%22">Rossetti D</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Han+S%22">Han S</searchLink>; Gurdon Institute, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Tang+MKS%22">Tang MKS</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Bejar+MT%22">Bejar MT</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Colom+B%22">Colom B</searchLink>; Wellcome Sanger Institute, Hinxton, UK.; Cambridge Institute of Science, Altos Labs, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Fowler+JC%22">Fowler JC</searchLink>; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Murai+K%22">Murai K</searchLink>; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Knight+W%22">Knight W</searchLink>; Wellcome Sanger Institute, Hinxton, UK.<br /><searchLink fieldCode="AU" term="%22Aust+D%22">Aust D</searchLink>; University Hospital Carl Gustav Carus Dresden, Faculty of Medicine of TUD Dresden University of Technology, Dresden, Germany.; Institute of Pathology, University Hospital CGC Dresden, TU Dresden, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Schmidt+MHH%22">Schmidt MHH</searchLink>; Institute of Anatomy, Faculty of Medicine of TUD, University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Jászai+J%22">Jászai J</searchLink>; Institute of Anatomy, Faculty of Medicine of TUD, University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Zeki+S%22">Zeki S</searchLink>; Department of Gastroenterology, Guy's and St. Thomas' Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Noorani+A%22">Noorani A</searchLink>; Wellcome Sanger Institute, Hinxton, UK.; Addenbrooke's Hospital, Cambridge University Hospital NHS Trust, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Jones+PH%22">Jones PH</searchLink>; Wellcome Sanger Institute, Hinxton, UK.; Department of Oncology, University of Cambridge, Hutchison Research Centre, Cambridge Biomedical Campus, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Rulands+S%22">Rulands S</searchLink>; Max Planck Institute for the Physics of Complex Systems, Dresden, Germany.; Arnold Sommerfeld Center for Theoretical Physics, Ludwigs-Maximilians-Universität Munchen, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Simons+BD%22">Simons BD</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK.; Gurdon Institute, University of Cambridge, Cambridge, UK.; Department of Applied Mathematics and Theoretical Physics, Centre for Mathematical Science, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Alcolea+MP%22">Alcolea MP</searchLink>; Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge, UK. mpa28@cam.ac.uk.; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. mpa28@cam.ac.uk.
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