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Genome modelling and design across all domains of life with Evo 2.

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Title: Genome modelling and design across all domains of life with Evo 2.
Authors: Brixi G; Arc Institute, Palo Alto, CA, USA.; Evo 2 Core Team, Palo Alto, CA, USA.; Stanford University, Stanford, CA, USA., Durrant MG; Arc Institute, Palo Alto, CA, USA.; Evo 2 Core Team, Palo Alto, CA, USA., Ku J; Arc Institute, Palo Alto, CA, USA.; Evo 2 Core Team, Palo Alto, CA, USA., Naghipourfar M; Arc Institute, Palo Alto, CA, USA.; Evo 2 Core Team, Palo Alto, CA, USA.; University of California, Berkeley, Berkeley, CA, USA., Poli M; Evo 2 Core Team, Palo Alto, CA, USA.; Stanford University, Stanford, CA, USA.; Liquid AI, San Francisco, CA, USA., Sun G; Arc Institute, Palo Alto, CA, USA.; Evo 2 Core Team, Palo Alto, CA, USA., Brockman G; Evo 2 Core Team, Palo Alto, CA, USA.; Independent Researcher, San Francisco, CA, USA.; OpenAI, San Francisco, CA, USA., Chang D; Arc Institute, Palo Alto, CA, USA.; Evo 2 Core Team, Palo Alto, CA, USA.; Stanford University, Stanford, CA, USA., Fanton A; Arc Institute, Palo Alto, CA, USA.; Evo 2 Core Team, Palo Alto, CA, USA., Gonzalez GA; Arc Institute, Palo Alto, CA, USA.; Evo 2 Core Team, Palo Alto, CA, USA., King SH; Arc Institute, Palo Alto, CA, USA.; Evo 2 Core Team, Palo Alto, CA, USA.; Stanford University, Stanford, CA, USA., Li DB; Arc Institute, Palo Alto, CA, USA.; Evo 2 Core Team, Palo Alto, CA, USA.; Stanford University, Stanford, CA, USA., Merchant AT; Arc Institute, Palo Alto, CA, USA.; Evo 2 Core Team, Palo Alto, CA, USA.; Stanford University, Stanford, CA, USA., Nguyen E; Evo 2 Core Team, Palo Alto, CA, USA.; Stanford University, Stanford, CA, USA., Ricci-Tam C; Arc Institute, Palo Alto, CA, USA.; Evo 2 Core Team, Palo Alto, CA, USA., Romero DW; Evo 2 Core Team, Palo Alto, CA, USA.; NVIDIA, Santa Clara, CA, USA., Schmok JC; Arc Institute, Palo Alto, CA, USA.; Evo 2 Core Team, Palo Alto, CA, USA., Taghibakhshi A; Evo 2 Core Team, Palo Alto, CA, USA.; NVIDIA, Santa Clara, CA, USA., Vorontsov A; Evo 2 Core Team, Palo Alto, CA, USA.; NVIDIA, Santa Clara, CA, USA., Yang B; Evo 2 Core Team, Palo Alto, CA, USA.; Independent Researcher, San Francisco, CA, USA., Deng M; Goodfire, San Francisco, CA, USA., Gorton L; Goodfire, San Francisco, CA, USA., Nguyen N; Goodfire, San Francisco, CA, USA., Wang NK; Goodfire, San Francisco, CA, USA., Pearce MT; Goodfire, San Francisco, CA, USA., Simon E; Goodfire, San Francisco, CA, USA., Adams E; Columbia University, New York, NY, USA., Amador ZJ; University of Washington, Seattle, WA, USA., Ashley EA; Stanford University, Stanford, CA, USA., Baccus SA; Stanford University, Stanford, CA, USA., Dai H; Stanford University, Stanford, CA, USA., Dillmann S; Stanford University, Stanford, CA, USA., Ermon S; Stanford University, Stanford, CA, USA., Guo D; Arc Institute, Palo Alto, CA, USA.; Stanford University, Stanford, CA, USA., Herschl MH; Arc Institute, Palo Alto, CA, USA.; University of California, Berkeley, Berkeley, CA, USA., Ilango R; Arc Institute, Palo Alto, CA, USA., Janik K; NVIDIA, Santa Clara, CA, USA., Lu AX; University of California, Berkeley, Berkeley, CA, USA., Mehta R; Arc Institute, Palo Alto, CA, USA., Mofrad MRK; University of California, Berkeley, Berkeley, CA, USA., Ng MY; Stanford University, Stanford, CA, USA., Pannu J; Johns Hopkins University, Baltimore, MD, USA., Ré C; Stanford University, Stanford, CA, USA., St John J; NVIDIA, Santa Clara, CA, USA., Sullivan J; Arc Institute, Palo Alto, CA, USA., Tey J; Arc Institute, Palo Alto, CA, USA.; Stanford University, Stanford, CA, USA., Viggiano B; Stanford University, Stanford, CA, USA., Zhu K; University of California, Berkeley, Berkeley, CA, USA., Zynda G; NVIDIA, Santa Clara, CA, USA., Balsam D; Goodfire, San Francisco, CA, USA., Collison P; Arc Institute, Palo Alto, CA, USA., Costa AB; NVIDIA, Santa Clara, CA, USA., Hernandez-Boussard T; Stanford University, Stanford, CA, USA., Ho E; Goodfire, San Francisco, CA, USA., Liu MY; NVIDIA, Santa Clara, CA, USA., McGrath T; Goodfire, San Francisco, CA, USA., Powell K; NVIDIA, Santa Clara, CA, USA., Pinglay S; Evo 2 Core Team, Palo Alto, CA, USA.; University of Washington, Seattle, WA, USA., Burke DP; Arc Institute, Palo Alto, CA, USA.; Evo 2 Core Team, Palo Alto, CA, USA., Goodarzi H; Arc Institute, Palo Alto, CA, USA.; Evo 2 Core Team, Palo Alto, CA, USA.; University of California, San Francisco, San Francisco, CA, USA., Hsu PD; Arc Institute, Palo Alto, CA, USA. patrick@arcinstitute.org.; Evo 2 Core Team, Palo Alto, CA, USA. patrick@arcinstitute.org.; University of California, Berkeley, Berkeley, CA, USA. patrick@arcinstitute.org., Hie BL; Arc Institute, Palo Alto, CA, USA. brianhie@stanford.edu.; Evo 2 Core Team, Palo Alto, CA, USA. brianhie@stanford.edu.; Stanford University, Stanford, CA, USA. brianhie@stanford.edu.
Source: Nature [Nature] 2026 Apr; Vol. 652 (8112), pp. 1349-1361. Date of Electronic Publication: 2026 Mar 04.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Genome modelling and design across all domains of life with Evo 2.
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            NameFull: Hie BL
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 04
              Text: 2026 Apr
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-electronic
              Value: 1476-4687
          Numbering:
            – Type: volume
              Value: 652
            – Type: issue
              Value: 8112
          Titles:
            – TitleFull: Nature
              Type: main
ResultId 1