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Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing.

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Title: Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing.
Authors: Li X; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany.; Department of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China., Schirra C; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany., Wirkner ML; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany., Tu SM; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany., Lin CH; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany., Hohmann M; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany., Gu Y; Institute for Clinical and Experimental Surgery, Saarland University, PharmaScienceHub (PSH), Homburg, Germany., Santiago L; Nanotoxicology and Immunotoxicology Unit (UNATI), IIS Aragón, Zaragoza, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain., Pardo J; Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.; Centre for Biomedical Research of Aragon (CIBA), IIS Aragon/University of Zaragoza, Zaragoza, Spain.; Red RICOS de Terapias Avanzadas TERAV+ and CERTERA, Consorcio Estatal en Red para el desarrollo de Medicamentos de Terapias Avanzadas, IS Carlos III, Madrid, Spain., Arretxe I; Centre for Biomedical Research of Aragon (CIBA), IIS Aragon/University of Zaragoza, Zaragoza, Spain., Alawar N; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany., Chouaib AA; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany., Becherer U; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany., Lee PH; Department of Biomedical Sciences and Engineering, Tzu Chi University, Hualien, Taiwan, China., Hsu HJ; Department of Biomedical Sciences and Engineering, Tzu Chi University, Hualien, Taiwan, China., Laschke MW; Institute for Clinical and Experimental Surgery, Saarland University, PharmaScienceHub (PSH), Homburg, Germany., Baldari CT; Department of Life Sciences, University of Siena, Siena, Italy., Dustin ML; Chinese Academy of Medical Sciences-Oxford Institute and Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK., Rettig J; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany., Krause E; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany. elmar.krause@uks.eu., Chang HF; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany. Hsin-Fang.Chang@uks.eu.
Source: Cellular & molecular immunology [Cell Mol Immunol] 2026 Apr; Vol. 23 (4), pp. 400-416. Date of Electronic Publication: 2026 Mar 04.
Publication Type: Journal Article
Journal Info: Publisher: Chinese Society of Immunology Country of Publication: China NLM ID: 101242872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2042-0226 (Electronic) Linking ISSN: 16727681 NLM ISO Abbreviation: Cell Mol Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Lytic IFNγ is stored in cytotoxic granules and coreleased with granzyme B to mediate cytotoxic T lymphocyte killing.
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  Data: <searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany.; Department of Neurology, NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.<br /><searchLink fieldCode="AU" term="%22Schirra+C%22">Schirra C</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Wirkner+ML%22">Wirkner ML</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Tu+SM%22">Tu SM</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lin+CH%22">Lin CH</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hohmann+M%22">Hohmann M</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Gu+Y%22">Gu Y</searchLink>; Institute for Clinical and Experimental Surgery, Saarland University, PharmaScienceHub (PSH), Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Santiago+L%22">Santiago L</searchLink>; Nanotoxicology and Immunotoxicology Unit (UNATI), IIS Aragón, Zaragoza, Spain.; Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Pardo+J%22">Pardo J</searchLink>; Centro de Investigación Biomédica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.; Centre for Biomedical Research of Aragon (CIBA), IIS Aragon/University of Zaragoza, Zaragoza, Spain.; Red RICOS de Terapias Avanzadas TERAV+ and CERTERA, Consorcio Estatal en Red para el desarrollo de Medicamentos de Terapias Avanzadas, IS Carlos III, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Arretxe+I%22">Arretxe I</searchLink>; Centre for Biomedical Research of Aragon (CIBA), IIS Aragon/University of Zaragoza, Zaragoza, Spain.<br /><searchLink fieldCode="AU" term="%22Alawar+N%22">Alawar N</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Chouaib+AA%22">Chouaib AA</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Becherer+U%22">Becherer U</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Lee+PH%22">Lee PH</searchLink>; Department of Biomedical Sciences and Engineering, Tzu Chi University, Hualien, Taiwan, China.<br /><searchLink fieldCode="AU" term="%22Hsu+HJ%22">Hsu HJ</searchLink>; Department of Biomedical Sciences and Engineering, Tzu Chi University, Hualien, Taiwan, China.<br /><searchLink fieldCode="AU" term="%22Laschke+MW%22">Laschke MW</searchLink>; Institute for Clinical and Experimental Surgery, Saarland University, PharmaScienceHub (PSH), Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Baldari+CT%22">Baldari CT</searchLink>; Department of Life Sciences, University of Siena, Siena, Italy.<br /><searchLink fieldCode="AU" term="%22Dustin+ML%22">Dustin ML</searchLink>; Chinese Academy of Medical Sciences-Oxford Institute and Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Rettig+J%22">Rettig J</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany.<br /><searchLink fieldCode="AU" term="%22Krause+E%22">Krause E</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany. elmar.krause@uks.eu.<br /><searchLink fieldCode="AU" term="%22Chang+HF%22">Chang HF</searchLink>; Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, (CIPMM), Saarland University, Homburg, Germany. Hsin-Fang.Chang@uks.eu.
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  Data: <searchLink fieldCode="JN" term="%22101242872%22">Cellular & molecular immunology</searchLink> [Cell Mol Immunol] 2026 Apr; Vol. 23 (4), pp. 400-416. <i>Date of Electronic Publication: </i>2026 Mar 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Chinese+Society+of+Immunology%22">Chinese Society of Immunology </searchLink><i>Country of Publication: </i>China <i>NLM ID: </i>101242872 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2042-0226 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216727681%22">16727681 </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Immunol <i>Subsets: </i>MEDLINE
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        Value: 10.1038/s41423-026-01391-1
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        Text: English
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