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Characterising the heterogeneity of heart failure with preserved ejection fraction: moving beyond subgroups and distinguishing disease from risk.

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Title: Characterising the heterogeneity of heart failure with preserved ejection fraction: moving beyond subgroups and distinguishing disease from risk.
Authors: Soltani F; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Manchester University NHS Foundation Trust, Manchester, UK., Black N; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Manchester University NHS Foundation Trust, Manchester, UK., Bradley J; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK., Priestner L; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Manchester University NHS Foundation Trust, Manchester, UK., Ko Ko N; Wrightington, Wigan, and Leigh NHS Foundation Trust, Wigan, Greater Manchester, UK., Glasse H; Northern Care Alliance NHS Foundation Trust, Salford, Greater Manchester, UK., Milner I; Northern Care Alliance NHS Foundation Trust, Salford, Greater Manchester, UK., Kreppel S; Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK., Schmitt M; Manchester University NHS Foundation Trust, Manchester, UK., Nucifora G; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Manchester University NHS Foundation Trust, Manchester, UK., Petrie MC; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK., Al-Mohammad A; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK., McCann GP; Department of Cardiovascular Sciences and the National Institute for Health and Social Care Research (NIHR) Leicester Biomedical Research Centre, University of Leicester, Leicester, United Kingdom., Lumbers RT; University College London Hospitals NHS Foundation Trust, London, UK.; Institute of Health Informatics, Faculty of Population Health Sciences, University College London, London, UK., Beezer J; South Tyneside and Sunderland Foundation Trust. Sunderland Royal Hospital, Kayll Road, Sunderland. UK., Paton MF; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.; Leeds Teaching Hospitals NHS Trust, Leeds, UK., Robinson S; Imperial College Healthcare NHS Trust, London, UK., Hyland R; HCRG, BSW, England, United Kingdom., Hartshorne-Evans N; Pumping Marvellous, Preston, UK., Humphreys-Davies L; British Society for Heart Failure, London, UK., Raisi-Estabragh Z; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK., Petersen SE; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.; Health Data Research UK, London, UK., Newman WG; Division of Evolution, Infection and Genomics, School of Biological Sciences, The University of Manchester, Manchester, UK.; Manchester Centre for Genomic Medicine, Manchester University NHS Foundation Trust, Manchester, UK., McDonagh T; Kings College Hospital NHS Foundation Trust, London, UK., Mayet J; Imperial College Healthcare NHS Trust, London, UK., Williams SG; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Manchester University NHS Foundation Trust, Manchester, UK., Jenkins DA; Division of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK., Morris AP; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK., Peek N; Division of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; The Healthcare Improvement Studies Institute (THIS Institute), Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK., Miller CA; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Manchester University NHS Foundation Trust, Manchester, UK.; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
Source: European journal of heart failure [Eur J Heart Fail] 2026 Mar 05. Date of Electronic Publication: 2026 Mar 05.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 100887595 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0844 (Electronic) Linking ISSN: 13889842 NLM ISO Abbreviation: Eur J Heart Fail Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Soltani+F%22">Soltani F</searchLink>; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Manchester University NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Black+N%22">Black N</searchLink>; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Manchester University NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Bradley+J%22">Bradley J</searchLink>; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Priestner+L%22">Priestner L</searchLink>; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Manchester University NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Ko+Ko+N%22">Ko Ko N</searchLink>; Wrightington, Wigan, and Leigh NHS Foundation Trust, Wigan, Greater Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Glasse+H%22">Glasse H</searchLink>; Northern Care Alliance NHS Foundation Trust, Salford, Greater Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Milner+I%22">Milner I</searchLink>; Northern Care Alliance NHS Foundation Trust, Salford, Greater Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Kreppel+S%22">Kreppel S</searchLink>; Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK.<br /><searchLink fieldCode="AU" term="%22Schmitt+M%22">Schmitt M</searchLink>; Manchester University NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Nucifora+G%22">Nucifora G</searchLink>; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Manchester University NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Petrie+MC%22">Petrie MC</searchLink>; School of Cardiovascular and Metabolic Health, University of Glasgow, Glasgow, UK.<br /><searchLink fieldCode="AU" term="%22Al-Mohammad+A%22">Al-Mohammad A</searchLink>; Department of Infection, Immunity and Cardiovascular Disease, University of Sheffield, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22McCann+GP%22">McCann GP</searchLink>; Department of Cardiovascular Sciences and the National Institute for Health and Social Care Research (NIHR) Leicester Biomedical Research Centre, University of Leicester, Leicester, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Lumbers+RT%22">Lumbers RT</searchLink>; University College London Hospitals NHS Foundation Trust, London, UK.; Institute of Health Informatics, Faculty of Population Health Sciences, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Beezer+J%22">Beezer J</searchLink>; South Tyneside and Sunderland Foundation Trust. 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UK.<br /><searchLink fieldCode="AU" term="%22Paton+MF%22">Paton MF</searchLink>; Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK.; Leeds Teaching Hospitals NHS Trust, Leeds, UK.<br /><searchLink fieldCode="AU" term="%22Robinson+S%22">Robinson S</searchLink>; Imperial College Healthcare NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Hyland+R%22">Hyland R</searchLink>; HCRG, BSW, England, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Hartshorne-Evans+N%22">Hartshorne-Evans N</searchLink>; Pumping Marvellous, Preston, UK.<br /><searchLink fieldCode="AU" term="%22Humphreys-Davies+L%22">Humphreys-Davies L</searchLink>; British Society for Heart Failure, London, UK.<br /><searchLink fieldCode="AU" term="%22Raisi-Estabragh+Z%22">Raisi-Estabragh Z</searchLink>; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Petersen+SE%22">Petersen SE</searchLink>; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University London, London, UK.; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, London, UK.; Health Data Research UK, London, UK.<br /><searchLink fieldCode="AU" term="%22Newman+WG%22">Newman WG</searchLink>; Division of Evolution, Infection and Genomics, School of Biological Sciences, The University of Manchester, Manchester, UK.; Manchester Centre for Genomic Medicine, Manchester University NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22McDonagh+T%22">McDonagh T</searchLink>; Kings College Hospital NHS Foundation Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Mayet+J%22">Mayet J</searchLink>; Imperial College Healthcare NHS Trust, London, UK.<br /><searchLink fieldCode="AU" term="%22Williams+SG%22">Williams SG</searchLink>; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Manchester University NHS Foundation Trust, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Jenkins+DA%22">Jenkins DA</searchLink>; Division of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Morris+AP%22">Morris AP</searchLink>; Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Peek+N%22">Peek N</searchLink>; Division of Informatics, Imaging and Data Science, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.; The Healthcare Improvement Studies Institute (THIS Institute), Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Miller+CA%22">Miller CA</searchLink>; Division of Cardiovascular Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.; Manchester University NHS Foundation Trust, Manchester, UK.; NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.
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