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PTPN11-related Noonan syndrome predisposes to multifocal low-grade CNS tumors harboring FGFR1 variants.

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Title: PTPN11-related Noonan syndrome predisposes to multifocal low-grade CNS tumors harboring FGFR1 variants.
Authors: Kohanbash G; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA. gary.kohanbash@pitt.edu.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. gary.kohanbash@pitt.edu., Ryall S; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Brigham and Women's Hospital, Boston, MA, USA., Gary SE; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA., Hoffman LM; Division of Hematology-Oncology, Children's Hospital of Colorado, Aurora, CO, USA.; Johnson & Johnson, Phoenix, AZ, USA., Siddaway R; Division of Pathology, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada., Bendel AE; Division of Hematology-Oncology, Children's Minnesota, Minneapolis, MN, USA., Gripp KW; Division of Medical Genetics, Nemours Children's Health, Wilmington, DE, USA., Walter AW; Division of Hematology-Oncology, Nemours Children's Health, Wilmington, DE, USA., Hansford JR; Children's Cancer Centre, Royal Children's Hospital, Melbourne, Australia.; Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia., Smith AA; Division of Pediatric Hematology-Oncology, Arnold Palmer Hospital, Orlando, FL, USA., Wang H; School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA., Skaugen JM; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA., Tabori U; Division of Pediatric Hematology-Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada., Hawkins CE; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Pathology, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada., Broniscer A; Division of Pediatric Hematology-Oncology, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. albertobroniscer5704@gmail.com.; 32 Academy Street, Arlington, MA, 02476, USA. albertobroniscer5704@gmail.com.; Servier Pharmaceuticals, Boston, MA, USA. albertobroniscer5704@gmail.com.
Source: Journal of neuro-oncology [J Neurooncol] 2026 Mar 05; Vol. 177 (1). Date of Electronic Publication: 2026 Mar 05.
Publication Type: Journal Article; Multicenter Study
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 8309335 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-7373 (Electronic) Linking ISSN: 0167594X NLM ISO Abbreviation: J Neurooncol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: PTPN11-related Noonan syndrome predisposes to multifocal low-grade CNS tumors harboring FGFR1 variants.
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  Data: <searchLink fieldCode="AU" term="%22Kohanbash+G%22">Kohanbash G</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA. gary.kohanbash@pitt.edu.; Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. gary.kohanbash@pitt.edu.<br /><searchLink fieldCode="AU" term="%22Ryall+S%22">Ryall S</searchLink>; The Arthur and Sonia Labatt Brain Tumour Research Center, The Hospital for Sick Children, Toronto, ON, Canada.; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Brigham and Women's Hospital, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Gary+SE%22">Gary SE</searchLink>; Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Hoffman+LM%22">Hoffman LM</searchLink>; Division of Hematology-Oncology, Children's Hospital of Colorado, Aurora, CO, USA.; Johnson & Johnson, Phoenix, AZ, USA.<br /><searchLink fieldCode="AU" term="%22Siddaway+R%22">Siddaway R</searchLink>; Division of Pathology, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Bendel+AE%22">Bendel AE</searchLink>; Division of Hematology-Oncology, Children's Minnesota, Minneapolis, MN, USA.<br /><searchLink fieldCode="AU" term="%22Gripp+KW%22">Gripp KW</searchLink>; Division of Medical Genetics, Nemours Children's Health, Wilmington, DE, USA.<br /><searchLink fieldCode="AU" term="%22Walter+AW%22">Walter AW</searchLink>; Division of Hematology-Oncology, Nemours Children's Health, Wilmington, DE, USA.<br /><searchLink fieldCode="AU" term="%22Hansford+JR%22">Hansford JR</searchLink>; Children's Cancer Centre, Royal Children's Hospital, Melbourne, Australia.; Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, Australia.<br /><searchLink fieldCode="AU" term="%22Smith+AA%22">Smith AA</searchLink>; Division of Pediatric Hematology-Oncology, Arnold Palmer Hospital, Orlando, FL, USA.<br /><searchLink fieldCode="AU" term="%22Wang+H%22">Wang H</searchLink>; School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Skaugen+JM%22">Skaugen JM</searchLink>; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.<br /><searchLink fieldCode="AU" term="%22Tabori+U%22">Tabori U</searchLink>; Division of Pediatric Hematology-Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Hawkins+CE%22">Hawkins CE</searchLink>; Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.; Division of Pathology, Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Broniscer+A%22">Broniscer A</searchLink>; Division of Pediatric Hematology-Oncology, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. albertobroniscer5704@gmail.com.; 32 Academy Street, Arlington, MA, 02476, USA. albertobroniscer5704@gmail.com.; Servier Pharmaceuticals, Boston, MA, USA. albertobroniscer5704@gmail.com.
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  Data: <searchLink fieldCode="JN" term="%228309335%22">Journal of neuro-oncology</searchLink> [J Neurooncol] 2026 Mar 05; Vol. 177 (1). <i>Date of Electronic Publication: </i>2026 Mar 05.
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  Data: Journal Article; Multicenter Study
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>8309335 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1573-7373 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220167594X%22">0167594X </searchLink><i>NLM ISO Abbreviation: </i>J Neurooncol <i>Subsets: </i>MEDLINE
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      – TitleFull: PTPN11-related Noonan syndrome predisposes to multifocal low-grade CNS tumors harboring FGFR1 variants.
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              Text: 2026 Mar 05
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