Integrated metabolomics and network pharmacology reveal multi-target phytotherapeutic activities of Frankenia hirsuta against inflammation and diabetic neuropathy with cytotoxic potential.

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Title: Integrated metabolomics and network pharmacology reveal multi-target phytotherapeutic activities of Frankenia hirsuta against inflammation and diabetic neuropathy with cytotoxic potential.
Authors: Zokalih AH; Department of Pharmacognosy and Natural Products, Faculty of Pharmacy, Pharos University in Alexandria, Canal El Mahmoudia Street, Beside the Green Plaza Complex, Alexandria 21648, Egypt., El Hawary S; Department of Pharmacognosy, Cairo University, Kasr El Aini, Cairo 11562, Egypt., El Sayed AM; Department of Pharmacognosy, Cairo University, Kasr El Aini, Cairo 11562, Egypt., El Raey MA; Department of Phytochemistry and Plant Systematics, Pharmaceutical Division, National Research Centre, El Buhouth St, Dokki, Cairo 12622, Egypt., Abdelhameed MF; Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El Bohouth St, Dokki, Cairo 12622, Egypt., Toto SM; Department of Botany and Microbiology, Faculty of Science, Alexandria University, Alexandria 21568, Egypt., Dawood H; Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt., Raafat KM; Department of Pharmacognosy and Natural Products, Faculty of Pharmacy, Pharos University in Alexandria, Canal El Mahmoudia Street, Beside the Green Plaza Complex, Alexandria 21648, Egypt.
Source: The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2026 Mar 05; Vol. 78 (3).
Publication Type: Journal Article
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0376363 Publication Model: Print Cited Medium: Internet ISSN: 2042-7158 (Electronic) Linking ISSN: 00223573 NLM ISO Abbreviation: J Pharm Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Integrated metabolomics and network pharmacology reveal multi-target phytotherapeutic activities of Frankenia hirsuta against inflammation and diabetic neuropathy with cytotoxic potential.
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  Data: <searchLink fieldCode="AU" term="%22Zokalih+AH%22">Zokalih AH</searchLink>; Department of Pharmacognosy and Natural Products, Faculty of Pharmacy, Pharos University in Alexandria, Canal El Mahmoudia Street, Beside the Green Plaza Complex, Alexandria 21648, Egypt.<br /><searchLink fieldCode="AU" term="%22El+Hawary+S%22">El Hawary S</searchLink>; Department of Pharmacognosy, Cairo University, Kasr El Aini, Cairo 11562, Egypt.<br /><searchLink fieldCode="AU" term="%22El+Sayed+AM%22">El Sayed AM</searchLink>; Department of Pharmacognosy, Cairo University, Kasr El Aini, Cairo 11562, Egypt.<br /><searchLink fieldCode="AU" term="%22El+Raey+MA%22">El Raey MA</searchLink>; Department of Phytochemistry and Plant Systematics, Pharmaceutical Division, National Research Centre, El Buhouth St, Dokki, Cairo 12622, Egypt.<br /><searchLink fieldCode="AU" term="%22Abdelhameed+MF%22">Abdelhameed MF</searchLink>; Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El Bohouth St, Dokki, Cairo 12622, Egypt.<br /><searchLink fieldCode="AU" term="%22Toto+SM%22">Toto SM</searchLink>; Department of Botany and Microbiology, Faculty of Science, Alexandria University, Alexandria 21568, Egypt.<br /><searchLink fieldCode="AU" term="%22Dawood+H%22">Dawood H</searchLink>; Department of Pharmacognosy, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt.<br /><searchLink fieldCode="AU" term="%22Raafat+KM%22">Raafat KM</searchLink>; Department of Pharmacognosy and Natural Products, Faculty of Pharmacy, Pharos University in Alexandria, Canal El Mahmoudia Street, Beside the Green Plaza Complex, Alexandria 21648, Egypt.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>0376363 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>2042-7158 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200223573%22">00223573 </searchLink><i>NLM ISO Abbreviation: </i>J Pharm Pharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1093/jpp/rgag017
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      – TitleFull: Integrated metabolomics and network pharmacology reveal multi-target phytotherapeutic activities of Frankenia hirsuta against inflammation and diabetic neuropathy with cytotoxic potential.
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              Text: 2026 Mar 05
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              Y: 2026
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