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Design and development of 1,5-diarylpyrazole-based multitarget-directed ligands as dual COX-2/HDAC6 inhibitors for Alzheimer's disease therapy: Molecular dynamics and experimental insights.

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Title: Design and development of 1,5-diarylpyrazole-based multitarget-directed ligands as dual COX-2/HDAC6 inhibitors for Alzheimer's disease therapy: Molecular dynamics and experimental insights.
Authors: Abdelrahman KS; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, 71524, Egypt., Soltan OM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, 71524, Egypt., Abo Mansour HE; Biochemistry Department, Faculty of Pharmacy, Menoufia University, Shibin El-Kom, Egypt; Biochemistry Department, Faculty of Pharmacy, Menoufia National University, km Cairo-Alexandria Agricultural Road, Egypt., Nofal AE; Zoology Department, Faculty of Science, Menoufia University, Shebin El- Kom, Menoufia, 32511, Egypt., Eissa EA; Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Menoufia, Egypt., Salem HR; Department of Physiology, Faculty of Medicine, Menoufia University, Menoufia, Egypt., Mahfouz MM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Menoufia University, Shibin El-Kom, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Menoufia National University, km Cairo-Alexandria Agricultural Road, Egypt., El-Adawy SA; Biochemistry Department, Faculty of Pharmacy, Menoufia National University, km Cairo-Alexandria Agricultural Road, Egypt; Department of Biochemistry, Faculty of Pharmacy, Tanta University, Egypt., Ewies GSA; Medical Pharmacology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt., Hamdi A; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt., Elbadawi MM; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt., Abusabaa AHA; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt., El-Rashedy AA; Department of the Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Institute, National Research Centre (NRC), 33 El-Behouth St., Dokki, Giza, 12622, Egypt., Konno H; Department of Chemistry and Biological Engineering, Graduate School of Science and Engineering, Yamagata University, Jonan 4-3-16, Yonezawa, Yamagata, 992-8510, Japan. Electronic address: konno@yz.yamagata-u.ac.jp., Bass AKA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia National University, 70 km Cairo-Alexandria Agricultural Road, Menoufia, Egypt.
Source: European journal of medicinal chemistry [Eur J Med Chem] 2026 May 05; Vol. 309, pp. 118738. Date of Electronic Publication: 2026 Mar 02.
Publication Type: Journal Article
Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Abdelrahman+KS%22">Abdelrahman KS</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, 71524, Egypt.<br /><searchLink fieldCode="AU" term="%22Soltan+OM%22">Soltan OM</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, 71524, Egypt.<br /><searchLink fieldCode="AU" term="%22Abo+Mansour+HE%22">Abo Mansour HE</searchLink>; Biochemistry Department, Faculty of Pharmacy, Menoufia University, Shibin El-Kom, Egypt; Biochemistry Department, Faculty of Pharmacy, Menoufia National University, km Cairo-Alexandria Agricultural Road, Egypt.<br /><searchLink fieldCode="AU" term="%22Nofal+AE%22">Nofal AE</searchLink>; Zoology Department, Faculty of Science, Menoufia University, Shebin El- Kom, Menoufia, 32511, Egypt.<br /><searchLink fieldCode="AU" term="%22Eissa+EA%22">Eissa EA</searchLink>; Department of Anatomy and Embryology, Faculty of Medicine, Menoufia University, Menoufia, Egypt.<br /><searchLink fieldCode="AU" term="%22Salem+HR%22">Salem HR</searchLink>; Department of Physiology, Faculty of Medicine, Menoufia University, Menoufia, Egypt.<br /><searchLink fieldCode="AU" term="%22Mahfouz+MM%22">Mahfouz MM</searchLink>; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Menoufia University, Shibin El-Kom, Egypt; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Menoufia National University, km Cairo-Alexandria Agricultural Road, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Adawy+SA%22">El-Adawy SA</searchLink>; Biochemistry Department, Faculty of Pharmacy, Menoufia National University, km Cairo-Alexandria Agricultural Road, Egypt; Department of Biochemistry, Faculty of Pharmacy, Tanta University, Egypt.<br /><searchLink fieldCode="AU" term="%22Ewies+GSA%22">Ewies GSA</searchLink>; Medical Pharmacology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt.<br /><searchLink fieldCode="AU" term="%22Hamdi+A%22">Hamdi A</searchLink>; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt.<br /><searchLink fieldCode="AU" term="%22Elbadawi+MM%22">Elbadawi MM</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.<br /><searchLink fieldCode="AU" term="%22Abusabaa+AHA%22">Abusabaa AHA</searchLink>; Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt.<br /><searchLink fieldCode="AU" term="%22El-Rashedy+AA%22">El-Rashedy AA</searchLink>; Department of the Chemistry of Natural and Microbial Products, Pharmaceutical and Drug Industries Institute, National Research Centre (NRC), 33 El-Behouth St., Dokki, Giza, 12622, Egypt.<br /><searchLink fieldCode="AU" term="%22Konno+H%22">Konno H</searchLink>; Department of Chemistry and Biological Engineering, Graduate School of Science and Engineering, Yamagata University, Jonan 4-3-16, Yonezawa, Yamagata, 992-8510, Japan. Electronic address: konno@yz.yamagata-u.ac.jp.<br /><searchLink fieldCode="AU" term="%22Bass+AKA%22">Bass AKA</searchLink>; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia University, Menoufia, Egypt; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Menoufia National University, 70 km Cairo-Alexandria Agricultural Road, Menoufia, Egypt.
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