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Decreased Glucose Metabolism and Declined Chaperones Are Unique Features Required for the Survival of Senescent Fibroblasts and Pyruvate Dehydrogenase Is a Potent Senolytic Target.

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Title: Decreased Glucose Metabolism and Declined Chaperones Are Unique Features Required for the Survival of Senescent Fibroblasts and Pyruvate Dehydrogenase Is a Potent Senolytic Target.
Authors: Zhang M; The Laboratory of Medical Genetics, College of Basic Medicine, Harbin Medical University, Harbin, China., Hu Z; The Laboratory of Medical Genetics, College of Basic Medicine, Harbin Medical University, Harbin, China., Piao S; The Laboratory of Medical Genetics, College of Basic Medicine, Harbin Medical University, Harbin, China., Song Y; The Laboratory of Medical Genetics, College of Basic Medicine, Harbin Medical University, Harbin, China., Jia Y; Heilongjiang Provincial Key Laboratory of Child Development and Genetic Research, Harbin Medical University, Harbin, China., Liu J; Heilongjiang Provincial Key Laboratory of Child Development and Genetic Research, Harbin Medical University, Harbin, China., Zhao N; The 2nd Affiliated Hospital, Harbin Medical University, Harbin, China., Liu A; The Laboratory of Medical Genetics, College of Basic Medicine, Harbin Medical University, Harbin, China.; Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China (Harbin Medical University), Ministry of Education, Harbin, China., Fu S; The Laboratory of Medical Genetics, College of Basic Medicine, Harbin Medical University, Harbin, China.; Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China (Harbin Medical University), Ministry of Education, Harbin, China., Sun W; The Laboratory of Medical Genetics, College of Basic Medicine, Harbin Medical University, Harbin, China.; Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China (Harbin Medical University), Ministry of Education, Harbin, China., Xu H; The Tumor Hospital, Harbin Medical University, Harbin, China., Yang Y; The 2nd Affiliated Hospital, Harbin Medical University, Harbin, China., Gygi SP; Department of Cell Biology, Harvard Medical School, Boston, Massachusetts, USA., Zhou C; The Laboratory of Medical Genetics, College of Basic Medicine, Harbin Medical University, Harbin, China.; The 2nd Affiliated Hospital, Harbin Medical University, Harbin, China.; Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China (Harbin Medical University), Ministry of Education, Harbin, China.
Source: Aging cell [Aging Cell] 2026 Mar; Vol. 25 (3), pp. e70434.
Publication Type: Journal Article
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE
Database: MEDLINE Ultimate
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              Text: 2026 Mar
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