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Single-cell chromatin accessibility landscape of cardiac non-myocytes identifies tissue repair program during heart regeneration.

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Title: Single-cell chromatin accessibility landscape of cardiac non-myocytes identifies tissue repair program during heart regeneration.
Authors: Chen Z; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China.; Medical Faculty Heidelberg, Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany., Nie Y; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China.; Department of Geriatric Medicine, Shenzhen Longhua District Central Hospital, Guangdong, China., Huang L; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China., Zeng N; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China., Gong J; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China., Gao Y; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China., Wen Q; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China., Chen X; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China., Ji X; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China., Li Y; China National Center for Bioinformation, Beijing, P. R. China.; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, P. R. China.; University of Chinese Academy of Sciences, Beijing, P. R. China., Lan T; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China., Jiang L; China National Center for Bioinformation, Beijing, P. R. China. jiangl@big.ac.cn.; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, P. R. China. jiangl@big.ac.cn.; University of Chinese Academy of Sciences, Beijing, P. R. China. jiangl@big.ac.cn., Wang J; School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Shandong, China. jiawang@uor.edu.cn., Xu J; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangdong, China. xujin7@mail.sysu.edu.cn., Cao N; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China. caon3@mail.sysu.edu.cn.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China. caon3@mail.sysu.edu.cn.
Source: NPJ Regenerative medicine [NPJ Regen Med] 2026 Mar 05; Vol. 11 (1). Date of Electronic Publication: 2026 Mar 05.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group, published in partnership with Monash University and Australian Regenerative Medicine Institute Country of Publication: United States NLM ID: 101699846 Publication Model: Electronic Cited Medium: Internet ISSN: 2057-3995 (Electronic) Linking ISSN: 20573995 NLM ISO Abbreviation: NPJ Regen Med Subsets: PubMed not MEDLINE
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  Data: Single-cell chromatin accessibility landscape of cardiac non-myocytes identifies tissue repair program during heart regeneration.
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  Data: <searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China.; Medical Faculty Heidelberg, Institute of Experimental Cardiology, Heidelberg University, Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Nie+Y%22">Nie Y</searchLink>; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China.; Department of Geriatric Medicine, Shenzhen Longhua District Central Hospital, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Huang+L%22">Huang L</searchLink>; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Zeng+N%22">Zeng N</searchLink>; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Gong+J%22">Gong J</searchLink>; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Gao+Y%22">Gao Y</searchLink>; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Wen+Q%22">Wen Q</searchLink>; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Chen+X%22">Chen X</searchLink>; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Ji+X%22">Ji X</searchLink>; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; China National Center for Bioinformation, Beijing, P. R. China.; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, P. R. China.; University of Chinese Academy of Sciences, Beijing, P. R. China.<br /><searchLink fieldCode="AU" term="%22Lan+T%22">Lan T</searchLink>; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China.<br /><searchLink fieldCode="AU" term="%22Jiang+L%22">Jiang L</searchLink>; China National Center for Bioinformation, Beijing, P. R. China. jiangl@big.ac.cn.; Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, P. R. China. jiangl@big.ac.cn.; University of Chinese Academy of Sciences, Beijing, P. R. China. jiangl@big.ac.cn.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; School of Health and Life Sciences, University of Health and Rehabilitation Sciences, Shandong, China. jiawang@uor.edu.cn.<br /><searchLink fieldCode="AU" term="%22Xu+J%22">Xu J</searchLink>; State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangdong, China. xujin7@mail.sysu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Cao+N%22">Cao N</searchLink>; Zhongshan School of Medicine and the Seventh Affiliated Hospital, Sun Yat-Sen University, Guangdong, China. caon3@mail.sysu.edu.cn.; Key Laboratory for Stem Cells and Tissue Engineering (Sun Yat-Sen University), Ministry of Education, Guangdong, China. caon3@mail.sysu.edu.cn.
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