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USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion.

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Title: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion.
Authors: Collotta G; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Gatti M; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Ungureanu IM; UK Dementia Research Institute, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., van Ackeren V; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Rannou E; Department of Plant and Microbial Biology, University of Zurich, Zurich, Switzerland., Vivalda F; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Gomez Vieito D; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Fishwick KM; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., von Aesch C; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Porro A; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland., Ungerleider K; UK Dementia Research Institute, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK., Heidari A; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada., Guérois R; Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), Gif-sur-Yvette, France., Harding RJ; Structural Genomics Consortium, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON, Canada.; Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada., Bischof S; Department of Plant and Microbial Biology, University of Zurich, Zurich, Switzerland., Balmus G; UK Dementia Research Institute, Department of Clinical Neurosciences, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK. gb318@cam.ac.uk.; Department of Molecular Neuroscience, Transylvanian Institute of Neuroscience, Cluj-Napoca, Romania. gb318@cam.ac.uk., Sartori AA; Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland. sartori@imcr.uzh.ch.
Source: Nature communications [Nat Commun] 2026 Mar 06; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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  Data: USP7 deubiquitinase stabilizes FAN1 to support DNA crosslink repair and suppress CAG repeat expansion.
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