Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis.
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| Title: | Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis. |
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| Authors: | Alhathli E; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK.; Faculty of Nursing, Taif University, Taif, Saudi Arabia., Cooper-Knock J; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK. j.cooper-knock@sheffield.ac.uk.; NIHR Sheffield Biomedical Research Centre (BRC), Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield, S10 2JF, UK. j.cooper-knock@sheffield.ac.uk., Girach ZU; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK., Julian TH; Division of Evolution, Infection and Genomics, School of Biological Sciences, The University of Manchester, Manchester, UK.; Christabel Pankhurst Institute, The University of Manchester, Manchester, UK., Bauer C; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK., Timmons HO; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK., Ward BD; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK., Walker H; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK., Azzouz M; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK., Elrayess MA; Biomedical Research Center (BRC), QU Health, Qatar University, P.O. Box 2713, Doha, Qatar., Al-Khelaifi F; Anti-Doping Laboratory Qatar, Doha, Qatar., Yousri NA; Computer and Systems Engineering, Faculty of Engineering, Alexandria University, Alexandria, Egypt., Gul A; Department of Medical Biology, Tayfur Ata Sökmen Medical Faculty, Hatay Mustafa Kemal University, Antakya, Turkey., Kelsall A; School of Medicine and Population Health, University of Sheffield, Sheffield, UK., Moll T; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK., Harvey C; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK., Gornall S; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK., Wong K; Metabolon Inc, Durham, NC, USA., Allen SP; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK., Strange A; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK. a.strange@sheffield.ac.uk.; NIHR Sheffield Biomedical Research Centre (BRC), Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield, S10 2JF, UK. a.strange@sheffield.ac.uk., Shaw PJ; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK. pamela.shaw@sheffield.ac.uk.; NIHR Sheffield Biomedical Research Centre (BRC), Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield, S10 2JF, UK. pamela.shaw@sheffield.ac.uk. |
| Source: | BMC medicine [BMC Med] 2026 Mar 06; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 06. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: BioMed Central Country of Publication: England NLM ID: 101190723 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-7015 (Electronic) Linking ISSN: 17417015 NLM ISO Abbreviation: BMC Med Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 41787388 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Alhathli+E%22">Alhathli E</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK.; Faculty of Nursing, Taif University, Taif, Saudi Arabia.<br /><searchLink fieldCode="AU" term="%22Cooper-Knock+J%22">Cooper-Knock J</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK. j.cooper-knock@sheffield.ac.uk.; NIHR Sheffield Biomedical Research Centre (BRC), Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield, S10 2JF, UK. j.cooper-knock@sheffield.ac.uk.<br /><searchLink fieldCode="AU" term="%22Girach+ZU%22">Girach ZU</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Julian+TH%22">Julian TH</searchLink>; Division of Evolution, Infection and Genomics, School of Biological Sciences, The University of Manchester, Manchester, UK.; Christabel Pankhurst Institute, The University of Manchester, Manchester, UK.<br /><searchLink fieldCode="AU" term="%22Bauer+C%22">Bauer C</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Timmons+HO%22">Timmons HO</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Ward+BD%22">Ward BD</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Walker+H%22">Walker H</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Azzouz+M%22">Azzouz M</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Elrayess+MA%22">Elrayess MA</searchLink>; Biomedical Research Center (BRC), QU Health, Qatar University, P.O. Box 2713, Doha, Qatar.<br /><searchLink fieldCode="AU" term="%22Al-Khelaifi+F%22">Al-Khelaifi F</searchLink>; Anti-Doping Laboratory Qatar, Doha, Qatar.<br /><searchLink fieldCode="AU" term="%22Yousri+NA%22">Yousri NA</searchLink>; Computer and Systems Engineering, Faculty of Engineering, Alexandria University, Alexandria, Egypt.<br /><searchLink fieldCode="AU" term="%22Gul+A%22">Gul A</searchLink>; Department of Medical Biology, Tayfur Ata Sökmen Medical Faculty, Hatay Mustafa Kemal University, Antakya, Turkey.<br /><searchLink fieldCode="AU" term="%22Kelsall+A%22">Kelsall A</searchLink>; School of Medicine and Population Health, University of Sheffield, Sheffield, UK.<br /><searchLink fieldCode="AU" term="%22Moll+T%22">Moll T</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Harvey+C%22">Harvey C</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Gornall+S%22">Gornall S</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Wong+K%22">Wong K</searchLink>; Metabolon Inc, Durham, NC, USA.<br /><searchLink fieldCode="AU" term="%22Allen+SP%22">Allen SP</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK.<br /><searchLink fieldCode="AU" term="%22Strange+A%22">Strange A</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK. a.strange@sheffield.ac.uk.; NIHR Sheffield Biomedical Research Centre (BRC), Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield, S10 2JF, UK. a.strange@sheffield.ac.uk.<br /><searchLink fieldCode="AU" term="%22Shaw+PJ%22">Shaw PJ</searchLink>; Sheffield Institute for Translational Neuroscience, University of Sheffield, Glossop Road, Sheffield, S10 2HQ, UK. pamela.shaw@sheffield.ac.uk.; NIHR Sheffield Biomedical Research Centre (BRC), Sheffield Teaching Hospitals NHS Foundation Trust, Glossop Road, Sheffield, S10 2JF, UK. pamela.shaw@sheffield.ac.uk. – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22101190723%22">BMC medicine</searchLink> [BMC Med] 2026 Mar 06; Vol. 24 (1). <i>Date of Electronic Publication: </i>2026 Mar 06. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101190723 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1741-7015 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2217417015%22">17417015 </searchLink><i>NLM ISO Abbreviation: </i>BMC Med <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41787388 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1186/s12916-026-04727-w Languages: – Code: eng Text: English Titles: – TitleFull: Hypothesis-free evaluation of circulating metabolome provides cell-specific insights regarding the role of energy substrate availability in amyotrophic lateral sclerosis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Alhathli E – PersonEntity: Name: NameFull: Cooper-Knock J – PersonEntity: Name: NameFull: Girach ZU – PersonEntity: Name: NameFull: Julian TH – PersonEntity: Name: NameFull: Bauer C – PersonEntity: Name: NameFull: Timmons HO – PersonEntity: Name: NameFull: Ward BD – PersonEntity: Name: NameFull: Walker H – PersonEntity: Name: NameFull: Azzouz M – PersonEntity: Name: NameFull: Elrayess MA – PersonEntity: Name: NameFull: Al-Khelaifi F – PersonEntity: Name: NameFull: Yousri NA – PersonEntity: Name: NameFull: Gul A – PersonEntity: Name: NameFull: Kelsall A – PersonEntity: Name: NameFull: Moll T – PersonEntity: Name: NameFull: Harvey C – PersonEntity: Name: NameFull: Gornall S – PersonEntity: Name: NameFull: Wong K – PersonEntity: Name: NameFull: Allen SP – PersonEntity: Name: NameFull: Strange A – PersonEntity: Name: NameFull: Shaw PJ IsPartOfRelationships: – BibEntity: Dates: – D: 06 M: 03 Text: 2026 Mar 06 Type: published Y: 2026 Identifiers: – Type: issn-electronic Value: 1741-7015 Numbering: – Type: volume Value: 24 – Type: issue Value: 1 Titles: – TitleFull: BMC medicine Type: main |
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