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Small molecule modulation of the p75 neurotrophin receptor promotes dendritic spine resilience to pathogenic tau species and reduces their accumulation.

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Title: Small molecule modulation of the p75 neurotrophin receptor promotes dendritic spine resilience to pathogenic tau species and reduces their accumulation.
Authors: Yang T; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA., Ay Y; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA., Kaur S; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA., Butler RR 3rd; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA., Tran KC; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA., Liu H; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA., Langness VF; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA., Massa SM; Department of Neurology, San Francisco Veterans Affairs Health Care System, San Francisco, CA, 94121, USA. Stephen.Massa@ucsf.edu.; Department of Neurology, University of California, San Francisco, San Francisco, CA, 94121, USA. Stephen.Massa@ucsf.edu., Longo FM; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA. flongo@stanford.edu.; Wu Tsai Neuroscience Institute, Stanford University, Stanford, CA, 94305, USA. flongo@stanford.edu.
Source: Acta neuropathologica communications [Acta Neuropathol Commun] 2026 Mar 05; Vol. 14 (1). Date of Electronic Publication: 2026 Mar 05.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101610673 Publication Model: Electronic Cited Medium: Internet ISSN: 2051-5960 (Electronic) Linking ISSN: 20515960 NLM ISO Abbreviation: Acta Neuropathol Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Small molecule modulation of the p75 neurotrophin receptor promotes dendritic spine resilience to pathogenic tau species and reduces their accumulation.
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  Data: <searchLink fieldCode="AU" term="%22Yang+T%22">Yang T</searchLink>; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA.<br /><searchLink fieldCode="AU" term="%22Ay+Y%22">Ay Y</searchLink>; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA.<br /><searchLink fieldCode="AU" term="%22Kaur+S%22">Kaur S</searchLink>; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA.<br /><searchLink fieldCode="AU" term="%22Butler+RR+3rd%22">Butler RR 3rd</searchLink>; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA.<br /><searchLink fieldCode="AU" term="%22Tran+KC%22">Tran KC</searchLink>; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA.<br /><searchLink fieldCode="AU" term="%22Liu+H%22">Liu H</searchLink>; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA.<br /><searchLink fieldCode="AU" term="%22Langness+VF%22">Langness VF</searchLink>; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA.<br /><searchLink fieldCode="AU" term="%22Massa+SM%22">Massa SM</searchLink>; Department of Neurology, San Francisco Veterans Affairs Health Care System, San Francisco, CA, 94121, USA. Stephen.Massa@ucsf.edu.; Department of Neurology, University of California, San Francisco, San Francisco, CA, 94121, USA. Stephen.Massa@ucsf.edu.<br /><searchLink fieldCode="AU" term="%22Longo+FM%22">Longo FM</searchLink>; Department of Neurology and Neurological Sciences, School of Medicine, Stanford University, 453 Quarry Road, Stanford, CA, 94304, USA. flongo@stanford.edu.; Wu Tsai Neuroscience Institute, Stanford University, Stanford, CA, 94305, USA. flongo@stanford.edu.
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  Data: <searchLink fieldCode="JN" term="%22101610673%22">Acta neuropathologica communications</searchLink> [Acta Neuropathol Commun] 2026 Mar 05; Vol. 14 (1). <i>Date of Electronic Publication: </i>2026 Mar 05.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22BioMed+Central%22">BioMed Central </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101610673 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>2051-5960 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220515960%22">20515960 </searchLink><i>NLM ISO Abbreviation: </i>Acta Neuropathol Commun <i>Subsets: </i>MEDLINE
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        Value: 10.1186/s40478-026-02263-5
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      – Code: eng
        Text: English
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      – TitleFull: Small molecule modulation of the p75 neurotrophin receptor promotes dendritic spine resilience to pathogenic tau species and reduces their accumulation.
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            – D: 05
              M: 03
              Text: 2026 Mar 05
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              Y: 2026
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