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Risk of Major Adverse Cardiovascular Events With Dolutegravir Versus Efavirenz-Based Antiretroviral Therapy: Emulated Target Trials Using Routine, De-identified Data From South Africa.

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Title: Risk of Major Adverse Cardiovascular Events With Dolutegravir Versus Efavirenz-Based Antiretroviral Therapy: Emulated Target Trials Using Routine, De-identified Data From South Africa.
Authors: Dorward J; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom.; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa., Masombuka X; Health Intelligence Unit, Discovery Health, Johannesburg, Gauteng, South Africa., Lewis L; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa., Pastellides C; Health Intelligence Unit, Discovery Health, Johannesburg, Gauteng, South Africa., van der Molen J; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa., Asare K; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.; Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, United Kingdom., Tlhaku K; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.; Discipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa., Brown JA; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom.; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa., Bottomley C; Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, United Kingdom., Jacobs D; Health Intelligence Unit, Discovery Health, Johannesburg, Gauteng, South Africa., Collie S; Health Intelligence Unit, Discovery Health, Johannesburg, Gauteng, South Africa., Garrett N; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.; Discipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
Source: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2026 Jul 08; Vol. 82 (6), pp. e1232-e1241.
Publication Type: Journal Article; Comparative Study
Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE
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  Data: <searchLink fieldCode="AU" term="%22Dorward+J%22">Dorward J</searchLink>; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom.; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.<br /><searchLink fieldCode="AU" term="%22Masombuka+X%22">Masombuka X</searchLink>; Health Intelligence Unit, Discovery Health, Johannesburg, Gauteng, South Africa.<br /><searchLink fieldCode="AU" term="%22Lewis+L%22">Lewis L</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.<br /><searchLink fieldCode="AU" term="%22Pastellides+C%22">Pastellides C</searchLink>; Health Intelligence Unit, Discovery Health, Johannesburg, Gauteng, South Africa.<br /><searchLink fieldCode="AU" term="%22van+der+Molen+J%22">van der Molen J</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.<br /><searchLink fieldCode="AU" term="%22Asare+K%22">Asare K</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.; Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Tlhaku+K%22">Tlhaku K</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.; Discipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.<br /><searchLink fieldCode="AU" term="%22Brown+JA%22">Brown JA</searchLink>; Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, Oxfordshire, United Kingdom.; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.<br /><searchLink fieldCode="AU" term="%22Bottomley+C%22">Bottomley C</searchLink>; Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, United Kingdom.<br /><searchLink fieldCode="AU" term="%22Jacobs+D%22">Jacobs D</searchLink>; Health Intelligence Unit, Discovery Health, Johannesburg, Gauteng, South Africa.<br /><searchLink fieldCode="AU" term="%22Collie+S%22">Collie S</searchLink>; Health Intelligence Unit, Discovery Health, Johannesburg, Gauteng, South Africa.<br /><searchLink fieldCode="AU" term="%22Garrett+N%22">Garrett N</searchLink>; Centre for the AIDS Programme of Research in South Africa (CAPRISA), University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.; Discipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa.; Desmond Tutu HIV Centre, University of Cape Town, Cape Town, South Africa.
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