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Identification of MTURN as a trained immunity-related biomarker for heart failure via integrative transcriptomic machine learning analysis and experimental validation.

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Title: Identification of MTURN as a trained immunity-related biomarker for heart failure via integrative transcriptomic machine learning analysis and experimental validation.
Authors: Yang T; Department of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Li Z; Department of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, United States., Pan M; Department of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.; Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, China., Wang X; Department of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Huang W; Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States., Kesten NE; Department of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.; Faculty of Medicine, Ondokuz Mayis University, Atakum, Samsun, Türkiye., Peng T; London Health Sciences Centre Research Institute, Departments of Medicine and Pathology and Laboratory Medicine, Western University, London, ON, Canada., Fan GC; Department of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
Source: Frontiers in immunology [Front Immunol] 2026 Feb 18; Vol. 17, pp. 1739660. Date of Electronic Publication: 2026 Feb 18 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Yang+T%22">Yang T</searchLink>; Department of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.<br /><searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Department of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.; Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, OH, United States.<br /><searchLink fieldCode="AU" term="%22Pan+M%22">Pan M</searchLink>; Department of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.; Department of Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Department of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.<br /><searchLink fieldCode="AU" term="%22Huang+W%22">Huang W</searchLink>; Division of Cardiovascular Health and Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, United States.<br /><searchLink fieldCode="AU" term="%22Kesten+NE%22">Kesten NE</searchLink>; Department of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.; Faculty of Medicine, Ondokuz Mayis University, Atakum, Samsun, Türkiye.<br /><searchLink fieldCode="AU" term="%22Peng+T%22">Peng T</searchLink>; London Health Sciences Centre Research Institute, Departments of Medicine and Pathology and Laboratory Medicine, Western University, London, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Fan+GC%22">Fan GC</searchLink>; Department of Pharmacology, Physiology, and Neurobiology, University of Cincinnati College of Medicine, Cincinnati, OH, United States.
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              Text: 2026 Feb 18
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