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All-atom simulations reveal distinct pathways for αIIbβ3 activation by biochemical vs. mechanical cues.

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Title: All-atom simulations reveal distinct pathways for αIIbβ3 activation by biochemical vs. mechanical cues.
Authors: Kolasangiani R; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA.; Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USA., Joshi O; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA.; Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USA., Schwartz MA; Department of Internal Medicine (Cardiology), Yale Cardiovascular Research Center, Yale University, New Haven, CT, USA.; Department of Cell Biology, Yale University, New Haven, CT, USA.; Department of Biomedical Engineering, School of Engineering and Applied Science, Yale University, New Haven, CT, USA., Bidone TC; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA. tamarabidone@sci.utah.edu.; Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USA. tamarabidone@sci.utah.edu.; Department of Biochemistry, University of Utah, Salt Lake City, UT, USA. tamarabidone@sci.utah.edu.; Department of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, USA. tamarabidone@sci.utah.edu.
Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2026 Mar 06; Vol. 83 (1). Date of Electronic Publication: 2026 Mar 06.
Publication Type: Journal Article
Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: All-atom simulations reveal distinct pathways for α<subscript>IIb</subscript>β<subscript>3</subscript> activation by biochemical vs. mechanical cues.
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  Data: <searchLink fieldCode="AU" term="%22Kolasangiani+R%22">Kolasangiani R</searchLink>; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA.; Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Joshi+O%22">Joshi O</searchLink>; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA.; Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USA.<br /><searchLink fieldCode="AU" term="%22Schwartz+MA%22">Schwartz MA</searchLink>; Department of Internal Medicine (Cardiology), Yale Cardiovascular Research Center, Yale University, New Haven, CT, USA.; Department of Cell Biology, Yale University, New Haven, CT, USA.; Department of Biomedical Engineering, School of Engineering and Applied Science, Yale University, New Haven, CT, USA.<br /><searchLink fieldCode="AU" term="%22Bidone+TC%22">Bidone TC</searchLink>; Department of Biomedical Engineering, University of Utah, Salt Lake City, UT, USA. tamarabidone@sci.utah.edu.; Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, USA. tamarabidone@sci.utah.edu.; Department of Biochemistry, University of Utah, Salt Lake City, UT, USA. tamarabidone@sci.utah.edu.; Department of Molecular Pharmaceutics, University of Utah, Salt Lake City, UT, USA. tamarabidone@sci.utah.edu.
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  Data: <searchLink fieldCode="JN" term="%229705402%22">Cellular and molecular life sciences : CMLS</searchLink> [Cell Mol Life Sci] 2026 Mar 06; Vol. 83 (1). <i>Date of Electronic Publication: </i>2026 Mar 06.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Springer%22">Springer </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9705402 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1420-9071 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%221420682X%22">1420682X </searchLink><i>NLM ISO Abbreviation: </i>Cell Mol Life Sci <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s00018-026-06138-9
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      – Code: eng
        Text: English
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              Text: 2026 Mar 06
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              Y: 2026
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