Oral co-exposure to Clostridioides difficile toxin A and ovalbumin disrupts intestinal homeostasis and predisposes to food allergy in mice.

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Title: Oral co-exposure to Clostridioides difficile toxin A and ovalbumin disrupts intestinal homeostasis and predisposes to food allergy in mice.
Authors: Xu X; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, PR China; College of Food Science & Technology, Nanchang University, Nanchang, 330031, PR China; Jiangxi Province Key Laboratory of Food Allergy, Nanchang, 330047, PR China; Jiangxi Province Engineering Research Center of Special Medical Purposes Intended for Allergic Population, PR China., Zeng X; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, PR China; College of Food Science & Technology, Nanchang University, Nanchang, 330031, PR China; Jiangxi Province Key Laboratory of Food Allergy, Nanchang, 330047, PR China; Jiangxi Province Engineering Research Center of Special Medical Purposes Intended for Allergic Population, PR China., Cheng Y; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, PR China; College of Food Science & Technology, Nanchang University, Nanchang, 330031, PR China; Jiangxi Province Key Laboratory of Food Allergy, Nanchang, 330047, PR China; Jiangxi Province Engineering Research Center of Special Medical Purposes Intended for Allergic Population, PR China., Yang P; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, PR China; College of Food Science & Technology, Nanchang University, Nanchang, 330031, PR China; Jiangxi Province Key Laboratory of Food Allergy, Nanchang, 330047, PR China; Jiangxi Province Engineering Research Center of Special Medical Purposes Intended for Allergic Population, PR China., Gao J; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, PR China; College of Food Science & Technology, Nanchang University, Nanchang, 330031, PR China; Jiangxi Province Key Laboratory of Food Allergy, Nanchang, 330047, PR China; Jiangxi Province Engineering Research Center of Special Medical Purposes Intended for Allergic Population, PR China., Meng X; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, PR China; Sino-German Joint Research Institute, Nanchang University, Nanchang, 330047, PR China; Jiangxi Province Key Laboratory of Food Allergy, Nanchang, 330047, PR China; Jiangxi Province Engineering Research Center of Special Medical Purposes Intended for Allergic Population, PR China., Wu Y; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, PR China; Sino-German Joint Research Institute, Nanchang University, Nanchang, 330047, PR China; Jiangxi Province Key Laboratory of Food Allergy, Nanchang, 330047, PR China; Jiangxi Province Engineering Research Center of Special Medical Purposes Intended for Allergic Population, PR China., Li X; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, PR China; College of Food Science & Technology, Nanchang University, Nanchang, 330031, PR China; Jiangxi Province Key Laboratory of Food Allergy, Nanchang, 330047, PR China; Jiangxi Province Engineering Research Center of Special Medical Purposes Intended for Allergic Population, PR China., Tong P; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, PR China; Jiangxi Province Key Laboratory of Food Allergy, Nanchang, 330047, PR China; Jiangxi Province Engineering Research Center of Special Medical Purposes Intended for Allergic Population, PR China. Electronic address: tongping@ncu.edu.cn., Chen H; State Key Laboratory of Food Science and Resources, Nanchang University, Nanchang, 330047, PR China; Sino-German Joint Research Institute, Nanchang University, Nanchang, 330047, PR China; Jiangxi Province Key Laboratory of Food Allergy, Nanchang, 330047, PR China; Jiangxi Province Engineering Research Center of Special Medical Purposes Intended for Allergic Population, PR China. Electronic address: chenhongbing@ncu.edu.cn.
Source: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2026 Jun 01; Vol. 275, pp. 109052. Date of Electronic Publication: 2026 Mar 04.
Publication Type: Journal Article
Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 1307333 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-3150 (Electronic) Linking ISSN: 00410101 NLM ISO Abbreviation: Toxicon Subsets: MEDLINE
Database: MEDLINE Ultimate
Description
ISSN:1879-3150
DOI:10.1016/j.toxicon.2026.109052