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Prothrombotic PROC variant rebalancing hemostasis in severe hemophilia A with attenuated bleeding risk.

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Title: Prothrombotic PROC variant rebalancing hemostasis in severe hemophilia A with attenuated bleeding risk.
Authors: Ramanan R; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium; Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia; Ronald Sawers Haemophilia Treatment Centre, Department of Haematology, Alfred Hospital, Melbourne, Victoria, Australia; Department of Human Molecular Pathology, Alfred Hospital, Melbourne, Victoria, Australia. Electronic address: r.ramanan@alfred.org.au., Van Thillo Q; Department of Vascular Medicine and Haemostasis, University Hospitals Leuven, Leuven, Belgium., Lavend'homme R; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium., Van Laer C; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium; Clinical Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium., Thys C; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium., De Wispelaere K; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium., Baert S; Centre for Human Genetics, University Hospitals Leuven, Leuven, Belgium., Kint C; Centre for Human Genetics, University Hospitals Leuven, Leuven, Belgium., Verhamme P; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium; Department of Vascular Medicine and Haemostasis, University Hospitals Leuven, Leuven, Belgium., Vanassche T; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium; Department of Vascular Medicine and Haemostasis, University Hospitals Leuven, Leuven, Belgium., McFadyen JD; Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia; Ronald Sawers Haemophilia Treatment Centre, Department of Haematology, Alfred Hospital, Melbourne, Victoria, Australia., Perkins AC; Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia; Department of Human Molecular Pathology, Alfred Hospital, Melbourne, Victoria, Australia., Tran HA; Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia; Ronald Sawers Haemophilia Treatment Centre, Department of Haematology, Alfred Hospital, Melbourne, Victoria, Australia., Labarque V; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium; Department of Paediatrics, Paediatric Haematology and Oncology, University Hospitals Leuven, Leuven, Belgium., Jacquemin M; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium; Clinical Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium., Freson K; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.
Source: Journal of thrombosis and haemostasis : JTH [J Thromb Haemost] 2026 Jun; Vol. 24 (6), pp. 2096-2102. Date of Electronic Publication: 2026 Mar 04.
Publication Type: Journal Article; Case Reports
Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 101170508 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7836 (Electronic) Linking ISSN: 15387836 NLM ISO Abbreviation: J Thromb Haemost Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Prothrombotic PROC variant rebalancing hemostasis in severe hemophilia A with attenuated bleeding risk.
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  Data: <searchLink fieldCode="AU" term="%22Ramanan+R%22">Ramanan R</searchLink>; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium; Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia; Ronald Sawers Haemophilia Treatment Centre, Department of Haematology, Alfred Hospital, Melbourne, Victoria, Australia; Department of Human Molecular Pathology, Alfred Hospital, Melbourne, Victoria, Australia. Electronic address: r.ramanan@alfred.org.au.<br /><searchLink fieldCode="AU" term="%22Van+Thillo+Q%22">Van Thillo Q</searchLink>; Department of Vascular Medicine and Haemostasis, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Lavend'homme+R%22">Lavend'homme R</searchLink>; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Van+Laer+C%22">Van Laer C</searchLink>; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium; Clinical Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Thys+C%22">Thys C</searchLink>; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22De+Wispelaere+K%22">De Wispelaere K</searchLink>; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Baert+S%22">Baert S</searchLink>; Centre for Human Genetics, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Kint+C%22">Kint C</searchLink>; Centre for Human Genetics, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Verhamme+P%22">Verhamme P</searchLink>; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium; Department of Vascular Medicine and Haemostasis, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Vanassche+T%22">Vanassche T</searchLink>; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium; Department of Vascular Medicine and Haemostasis, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22McFadyen+JD%22">McFadyen JD</searchLink>; Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia; Ronald Sawers Haemophilia Treatment Centre, Department of Haematology, Alfred Hospital, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Perkins+AC%22">Perkins AC</searchLink>; Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia; Department of Human Molecular Pathology, Alfred Hospital, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Tran+HA%22">Tran HA</searchLink>; Australian Centre for Blood Diseases, Monash University, Melbourne, Victoria, Australia; Ronald Sawers Haemophilia Treatment Centre, Department of Haematology, Alfred Hospital, Melbourne, Victoria, Australia.<br /><searchLink fieldCode="AU" term="%22Labarque+V%22">Labarque V</searchLink>; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium; Department of Paediatrics, Paediatric Haematology and Oncology, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Jacquemin+M%22">Jacquemin M</searchLink>; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium; Clinical Department of Laboratory Medicine, University Hospitals Leuven, Leuven, Belgium.<br /><searchLink fieldCode="AU" term="%22Freson+K%22">Freson K</searchLink>; Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Leuven, Belgium.
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  Data: <searchLink fieldCode="JN" term="%22101170508%22">Journal of thrombosis and haemostasis : JTH</searchLink> [J Thromb Haemost] 2026 Jun; Vol. 24 (6), pp. 2096-2102. <i>Date of Electronic Publication: </i>2026 Mar 04.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier%22">Elsevier </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>101170508 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1538-7836 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2215387836%22">15387836 </searchLink><i>NLM ISO Abbreviation: </i>J Thromb Haemost <i>Subsets: </i>MEDLINE
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        Value: 10.1016/j.jtha.2026.02.014
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        Text: English
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        StartPage: 2096
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              Text: 2026 Jun
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