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Venetoclax plus high-dose cytarabine and mitoxantrone as salvage treatment for relapsed or refractory acute myeloid leukaemia (RELAX): a multicentre, single-arm, phase 1/2 trial.

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Title: Venetoclax plus high-dose cytarabine and mitoxantrone as salvage treatment for relapsed or refractory acute myeloid leukaemia (RELAX): a multicentre, single-arm, phase 1/2 trial.
Authors: Ruhnke L; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Schliemann C; Department of Medicine A, University Hospital Münster, Münster, Germany., Mikesch JH; Department of Medicine A, University Hospital Münster, Münster, Germany., Stelljes M; Department of Medicine A, University Hospital Münster, Münster, Germany., Fransecky L; Department of Hematology and Oncology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Steffen B; Department of Internal Medicine II, University Hospital Frankfurt, Frankfurt, Germany., Kaufmann M; Department of Hematology, Oncology and Palliative Care, Robert-Bosch-Krankenhaus, Stuttgart, Germany., Burchert A; Department of Internal Medicine, Hematology, Oncology and Immunology, University Hospital Marburg, Marburg, Germany., Rank A; Department of Internal Medicine II, Hematology and Oncology, University Hospital Augsburg, Augsburg, Germany., Hanoun M; Department of Hematology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Höllein A; Department of Internal Medicine III, Hematology and Oncology, Rotkreuzklinikum München, Munich, Germany., Kraus S; Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany., Schäfer-Eckart K; Department of Internal Medicine V, Klinikum Nürnberg, Paracelsus Medical University, Nuremberg, Germany., Hänel M; Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany., Haake A; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Fiebig F; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Kramer M; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Zukunft S; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Kunadt D; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Middeke JM; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Sockel K; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Schetelig J; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Platzbecker U; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., von Bonin M; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Röhnert MA; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Oelschlägel U; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Wagenführ L; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Thiede C; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany; AgenDix, Dresden, Germany., Herold S; Institute of Pathology, Molecular Pathology, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Poitz D; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Stölzel F; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany; Department of Hematology and Oncology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Baldus CD; Department of Hematology and Oncology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany., Serve H; Department of Internal Medicine II, University Hospital Frankfurt, Frankfurt, Germany., Wermke M; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Bornhäuser M; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany., Röllig C; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany. Electronic address: christoph.roellig@ukdd.de.
Source: The Lancet. Haematology [Lancet Haematol] 2026 Mar; Vol. 13 (3), pp. e157-e168.
Publication Type: Journal Article; Multicenter Study; Clinical Trial, Phase II; Clinical Trial, Phase I
Journal Info: Publisher: Elsevier Ltd Country of Publication: England NLM ID: 101643584 Publication Model: Print Cited Medium: Internet ISSN: 2352-3026 (Electronic) Linking ISSN: 23523026 NLM ISO Abbreviation: Lancet Haematol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Venetoclax plus high-dose cytarabine and mitoxantrone as salvage treatment for relapsed or refractory acute myeloid leukaemia (RELAX): a multicentre, single-arm, phase 1/2 trial.
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  Data: <searchLink fieldCode="AU" term="%22Ruhnke+L%22">Ruhnke L</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Schliemann+C%22">Schliemann C</searchLink>; Department of Medicine A, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Mikesch+JH%22">Mikesch JH</searchLink>; Department of Medicine A, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Stelljes+M%22">Stelljes M</searchLink>; Department of Medicine A, University Hospital Münster, Münster, Germany.<br /><searchLink fieldCode="AU" term="%22Fransecky+L%22">Fransecky L</searchLink>; Department of Hematology and Oncology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Steffen+B%22">Steffen B</searchLink>; Department of Internal Medicine II, University Hospital Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Kaufmann+M%22">Kaufmann M</searchLink>; Department of Hematology, Oncology and Palliative Care, Robert-Bosch-Krankenhaus, Stuttgart, Germany.<br /><searchLink fieldCode="AU" term="%22Burchert+A%22">Burchert A</searchLink>; Department of Internal Medicine, Hematology, Oncology and Immunology, University Hospital Marburg, Marburg, Germany.<br /><searchLink fieldCode="AU" term="%22Rank+A%22">Rank A</searchLink>; Department of Internal Medicine II, Hematology and Oncology, University Hospital Augsburg, Augsburg, Germany.<br /><searchLink fieldCode="AU" term="%22Hanoun+M%22">Hanoun M</searchLink>; Department of Hematology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.<br /><searchLink fieldCode="AU" term="%22Höllein+A%22">Höllein A</searchLink>; Department of Internal Medicine III, Hematology and Oncology, Rotkreuzklinikum München, Munich, Germany.<br /><searchLink fieldCode="AU" term="%22Kraus+S%22">Kraus S</searchLink>; Department of Internal Medicine II, University Hospital Würzburg, Würzburg, Germany.<br /><searchLink fieldCode="AU" term="%22Schäfer-Eckart+K%22">Schäfer-Eckart K</searchLink>; Department of Internal Medicine V, Klinikum Nürnberg, Paracelsus Medical University, Nuremberg, Germany.<br /><searchLink fieldCode="AU" term="%22Hänel+M%22">Hänel M</searchLink>; Department of Internal Medicine III, Klinikum Chemnitz, Chemnitz, Germany.<br /><searchLink fieldCode="AU" term="%22Haake+A%22">Haake A</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Fiebig+F%22">Fiebig F</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Kramer+M%22">Kramer M</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Zukunft+S%22">Zukunft S</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Kunadt+D%22">Kunadt D</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Middeke+JM%22">Middeke JM</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Sockel+K%22">Sockel K</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Schetelig+J%22">Schetelig J</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Platzbecker+U%22">Platzbecker U</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22von+Bonin+M%22">von Bonin M</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Röhnert+MA%22">Röhnert MA</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Oelschlägel+U%22">Oelschlägel U</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Wagenführ+L%22">Wagenführ L</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Thiede+C%22">Thiede C</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany; AgenDix, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Herold+S%22">Herold S</searchLink>; Institute of Pathology, Molecular Pathology, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Poitz+D%22">Poitz D</searchLink>; Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Stölzel+F%22">Stölzel F</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany; Department of Hematology and Oncology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Baldus+CD%22">Baldus CD</searchLink>; Department of Hematology and Oncology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.<br /><searchLink fieldCode="AU" term="%22Serve+H%22">Serve H</searchLink>; Department of Internal Medicine II, University Hospital Frankfurt, Frankfurt, Germany.<br /><searchLink fieldCode="AU" term="%22Wermke+M%22">Wermke M</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Bornhäuser+M%22">Bornhäuser M</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany.<br /><searchLink fieldCode="AU" term="%22Röllig+C%22">Röllig C</searchLink>; Department of Internal Medicine I, University Hospital Dresden, TUD Dresden University of Technology, Dresden, Germany. Electronic address: christoph.roellig@ukdd.de.
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  Data: <searchLink fieldCode="JN" term="%22101643584%22">The Lancet. Haematology</searchLink> [Lancet Haematol] 2026 Mar; Vol. 13 (3), pp. e157-e168.
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