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ITK-targeted immune remodeling enhanced the efficacy of anti-CD19 CAR-T cell therapy.

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Title: ITK-targeted immune remodeling enhanced the efficacy of anti-CD19 CAR-T cell therapy.
Authors: Li Z; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Lymphoma Translational Research, Peking University Cancer Hospital & Institute, Beijing, China., Lv L; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Lymphoma Translational Research, Peking University Cancer Hospital & Institute, Beijing, China., Yao X; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Lymphoma Translational Research, Peking University Cancer Hospital & Institute, Beijing, China., Feng Z; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Lymphoma Translational Research, Peking University Cancer Hospital & Institute, Beijing, China., Xie Y; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China., Li K; Angel Pharmaceuticals Co. Ltd, Jiaxing, Zhejiang Province, China., Qi F; Beijing Imunopharm Technology Co. Ltd, Beijing, China., Yang M; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Lymphoma Translational Research, Peking University Cancer Hospital & Institute, Beijing, China., Wang J; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Lymphoma Translational Research, Peking University Cancer Hospital & Institute, Beijing, China., Pan T; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China., Li X; Angel Pharmaceuticals Co. Ltd, Jiaxing, Zhejiang Province, China., Chen H; Angel Pharmaceuticals Co. Ltd, Jiaxing, Zhejiang Province, China., Wang J; Beijing Imunopharm Technology Co. Ltd, Beijing, China., Ding Y; Beijing Imunopharm Technology Co. Ltd, Beijing, China., Zhu J; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China., Song Y; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China., Wang X; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Lymphoma Translational Research, Peking University Cancer Hospital & Institute, Beijing, China. wangxiaomin@bjmu.edu.cn., Ding N; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Lymphoma Translational Research, Peking University Cancer Hospital & Institute, Beijing, China. ningding@bjmu.edu.cn.
Source: Cell death discovery [Cell Death Discov] 2026 Mar 06; Vol. 12 (1). Date of Electronic Publication: 2026 Mar 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 101665035 Publication Model: Electronic Cited Medium: Print ISSN: 2058-7716 (Print) Linking ISSN: 20587716 NLM ISO Abbreviation: Cell Death Discov Subsets: PubMed not MEDLINE
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  Data: ITK-targeted immune remodeling enhanced the efficacy of anti-CD19 CAR-T cell therapy.
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  Data: <searchLink fieldCode="AU" term="%22Li+Z%22">Li Z</searchLink>; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Lymphoma Translational Research, Peking University Cancer Hospital & Institute, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lv+L%22">Lv L</searchLink>; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Lymphoma Translational Research, Peking University Cancer Hospital & Institute, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yao+X%22">Yao X</searchLink>; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Lymphoma Translational Research, Peking University Cancer Hospital & Institute, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Feng+Z%22">Feng Z</searchLink>; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Lymphoma Translational Research, Peking University Cancer Hospital & Institute, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Xie+Y%22">Xie Y</searchLink>; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+K%22">Li K</searchLink>; Angel Pharmaceuticals Co. Ltd, Jiaxing, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Qi+F%22">Qi F</searchLink>; Beijing Imunopharm Technology Co. Ltd, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yang+M%22">Yang M</searchLink>; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Lymphoma Translational Research, Peking University Cancer Hospital & Institute, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Lymphoma Translational Research, Peking University Cancer Hospital & Institute, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Pan+T%22">Pan T</searchLink>; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Li+X%22">Li X</searchLink>; Angel Pharmaceuticals Co. Ltd, Jiaxing, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Chen+H%22">Chen H</searchLink>; Angel Pharmaceuticals Co. Ltd, Jiaxing, Zhejiang Province, China.<br /><searchLink fieldCode="AU" term="%22Wang+J%22">Wang J</searchLink>; Beijing Imunopharm Technology Co. Ltd, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Ding+Y%22">Ding Y</searchLink>; Beijing Imunopharm Technology Co. Ltd, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhu+J%22">Zhu J</searchLink>; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Song+Y%22">Song Y</searchLink>; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Lymphoma, Peking University Cancer Hospital & Institute, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Lymphoma Translational Research, Peking University Cancer Hospital & Institute, Beijing, China. wangxiaomin@bjmu.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ding+N%22">Ding N</searchLink>; Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Lymphoma Translational Research, Peking University Cancer Hospital & Institute, Beijing, China. ningding@bjmu.edu.cn.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group%22">Nature Publishing Group </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101665035 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Print <i>ISSN: </i>2058-7716 (Print) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2220587716%22">20587716 </searchLink><i>NLM ISO Abbreviation: </i>Cell Death Discov <i>Subsets: </i>PubMed not MEDLINE
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      – TitleFull: ITK-targeted immune remodeling enhanced the efficacy of anti-CD19 CAR-T cell therapy.
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