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Necroptosis in both tumour and stromal compartments determines responsiveness to immunogenic cell death-based immunotherapy.

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Title: Necroptosis in both tumour and stromal compartments determines responsiveness to immunogenic cell death-based immunotherapy.
Authors: Fernando W; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Clucas J; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK. jarama.clucas@icr.ac.uk., Rizzo A; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Singer R; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Goode E; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Tiu C; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Layzell S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Konecnik J; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Wilson R; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Wicky John S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Jouny S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Guppy N; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Boulat V; Cancer Bioinformatics, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.; Immunity and Cancer Laboratory, The Francis Crick Institute, London, UK., Mannion J; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Goicoechea M; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Tan S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Lawson S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Starling C; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Elshtein G; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Ravindran N; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Montgomery AB; Centre for Inflammation Biology and Cancer Immunology, School of Immunology & Microbial Sciences, King's College London, London, UK., Andres-Ejarque R; Centre for Inflammation Biology and Cancer Immunology, School of Immunology & Microbial Sciences, King's College London, London, UK., Allen M; Biological Services Unit, The Institute of Cancer Research, London, UK., Lumbard S; Biological Services Unit, The Institute of Cancer Research, London, UK., Wallberg F; Quell Therapeutics Ltd, Translation & Innovation Hub, London, UK., Betteridge K; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Scrimgeour R; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Robertson D; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Ward G; Astex Pharmaceuticals, Cambridge, UK., Sims M; Astex Pharmaceuticals, Cambridge, UK., Smyth T; Astex Pharmaceuticals, Cambridge, UK., Samson AL; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia., Murphy JM; The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, Australia.; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia., Kolarevic Ivankovic D; The Royal Marsden NHS Foundation Trust, London, UK., Arwert EN; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Calado DP; Immunity and Cancer Laboratory, The Francis Crick Institute, London, UK., Grigoriadis A; Cancer Bioinformatics, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.; Breast Cancer Now Unit, School of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK., Smalley MJ; The European Cancer Stem Cell Research Institute, School of Biosciences, Cardiff University, Cardiff, UK., Melcher A; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Haider S; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Lawrence T; Centre for Inflammation Biology and Cancer Immunology, School of Immunology & Microbial Sciences, King's College London, London, UK.; Centre d'Immunologie Marseille-Luminy, CNRS, INSERM, Aix Marseille Universite, Marseille, France., Roxanis I; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK., Tutt ANJ; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK.; Breast Cancer Now Research Unit, King's College London, London, UK., Tenev T; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK. tencho.tenev@icr.ac.uk., Meier P; The Breast Cancer Now Toby Robins Research Centre, The Institute of Cancer Research, Fulham Road, London, UK. pascal.meier@icr.ac.uk.
Source: Nature communications [Nat Commun] 2026 Mar 06; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 06.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
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