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Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS-STING and Toll-like receptors 3 and 4.

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Title: Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS-STING and Toll-like receptors 3 and 4.
Authors: Betrancourt A; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK., Cinko MT; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., Varanda AB; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., Arias M; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.; Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.; Department of Microbiology, Paediatrics, Radiology and Preventive Medicine and Public Health, University of Zaragoza, Zaragoza, Spain., Uranga-Murillo I; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.; Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.; Department of Microbiology, Paediatrics, Radiology and Preventive Medicine and Public Health, University of Zaragoza, Zaragoza, Spain., Peña N; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.; Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.; Department of Microbiology, Paediatrics, Radiology and Preventive Medicine and Public Health, University of Zaragoza, Zaragoza, Spain., Kaps LM; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., Chau LF; Department of Pathology, University of Cambridge, Cambridge, UK., Buratti B; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany., Brägelmann J; Mildred Scheel School of Oncology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; Medical Clinic III for Oncology, Hematology, Immune-Oncology and Rheumatology, University Hospital of Bonn, Bonn, Germany., de Miguel D; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK.; Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain., Becker K; Cologne Centre for Genomics, Medical Faculty, University of Cologne, Cologne, Germany., Casper R; Cologne Centre for Genomics, Medical Faculty, University of Cologne, Cologne, Germany., Martin R; Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Madrid, Spain., Alcami A; Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Madrid, Spain., Ferguson BJ; Department of Pathology, University of Cambridge, Cambridge, UK., Pardo J; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.; Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.; Department of Microbiology, Paediatrics, Radiology and Preventive Medicine and Public Health, University of Zaragoza, Zaragoza, Spain., Rieser E; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany. erieser@uni-koeln.de.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany. erieser@uni-koeln.de.; Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK. erieser@uni-koeln.de.; Institute of Biochemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany. erieser@uni-koeln.de., Walczak H; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany. h.walczak@uni-koeln.de.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany. h.walczak@uni-koeln.de.; Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK. h.walczak@uni-koeln.de.
Source: Nature cell biology [Nat Cell Biol] 2026 Mar; Vol. 28 (3), pp. 608-621. Date of Electronic Publication: 2026 Mar 06.
Publication Type: Journal Article
Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE
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  Data: Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS-STING and Toll-like receptors 3 and 4.
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  Data: <searchLink fieldCode="AU" term="%22Betrancourt+A%22">Betrancourt A</searchLink>; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK.<br /><searchLink fieldCode="AU" term="%22Cinko+MT%22">Cinko MT</searchLink>; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Varanda+AB%22">Varanda AB</searchLink>; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Arias+M%22">Arias M</searchLink>; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.; Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.; Department of Microbiology, Paediatrics, Radiology and Preventive Medicine and Public Health, University of Zaragoza, Zaragoza, Spain.<br /><searchLink fieldCode="AU" term="%22Uranga-Murillo+I%22">Uranga-Murillo I</searchLink>; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.; Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.; Department of Microbiology, Paediatrics, Radiology and Preventive Medicine and Public Health, University of Zaragoza, Zaragoza, Spain.<br /><searchLink fieldCode="AU" term="%22Peña+N%22">Peña N</searchLink>; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.; Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.; Department of Microbiology, Paediatrics, Radiology and Preventive Medicine and Public Health, University of Zaragoza, Zaragoza, Spain.<br /><searchLink fieldCode="AU" term="%22Kaps+LM%22">Kaps LM</searchLink>; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Chau+LF%22">Chau LF</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Buratti+B%22">Buratti B</searchLink>; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Brägelmann+J%22">Brägelmann J</searchLink>; Mildred Scheel School of Oncology, University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Translational Genomics, Cologne, Germany.; Medical Clinic III for Oncology, Hematology, Immune-Oncology and Rheumatology, University Hospital of Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22de+Miguel+D%22">de Miguel D</searchLink>; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany.; Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK.; Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.<br /><searchLink fieldCode="AU" term="%22Becker+K%22">Becker K</searchLink>; Cologne Centre for Genomics, Medical Faculty, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Casper+R%22">Casper R</searchLink>; Cologne Centre for Genomics, Medical Faculty, University of Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Martin+R%22">Martin R</searchLink>; Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Alcami+A%22">Alcami A</searchLink>; Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas, Universidad Autónoma de Madrid, Madrid, Spain.<br /><searchLink fieldCode="AU" term="%22Ferguson+BJ%22">Ferguson BJ</searchLink>; Department of Pathology, University of Cambridge, Cambridge, UK.<br /><searchLink fieldCode="AU" term="%22Pardo+J%22">Pardo J</searchLink>; CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain.; Aragón Health Research Institute (IIS Aragón), Zaragoza, Spain.; Department of Microbiology, Paediatrics, Radiology and Preventive Medicine and Public Health, University of Zaragoza, Zaragoza, Spain.<br /><searchLink fieldCode="AU" term="%22Rieser+E%22">Rieser E</searchLink>; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany. erieser@uni-koeln.de.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany. erieser@uni-koeln.de.; Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK. erieser@uni-koeln.de.; Institute of Biochemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, University of Cologne, Cologne, Germany. erieser@uni-koeln.de.<br /><searchLink fieldCode="AU" term="%22Walczak+H%22">Walczak H</searchLink>; Cell Death, Inflammation and Immunity Laboratory, Institute of Biochemistry I, Faculty of Medicine, University of Cologne, Cologne, Germany. h.walczak@uni-koeln.de.; Cell Death, Inflammation and Immunity Laboratory, CECAD Cluster of Excellence, University of Cologne, Cologne, Germany. h.walczak@uni-koeln.de.; Centre for Cell Death, Cancer and Inflammation, UCL Cancer Institute, University College London, London, UK. h.walczak@uni-koeln.de.
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  Data: <searchLink fieldCode="JN" term="%22100890575%22">Nature cell biology</searchLink> [Nat Cell Biol] 2026 Mar; Vol. 28 (3), pp. 608-621. <i>Date of Electronic Publication: </i>2026 Mar 06.
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