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Optimized culture of primary human alveolar type II cell-derived 3D organoids from fibrotic lung tissue with phenotypic and metabolic profiling.

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Title: Optimized culture of primary human alveolar type II cell-derived 3D organoids from fibrotic lung tissue with phenotypic and metabolic profiling.
Authors: Schröder LJ; Institute for Pathology, Hannover Medical School, Hannover, Germany. Schroeder.lara-jasmin@mh-hannover.de.; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany. Schroeder.lara-jasmin@mh-hannover.de.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany. Schroeder.lara-jasmin@mh-hannover.de., Rückoldt J; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany., Schubert S; Institute for Pathology, Hannover Medical School, Hannover, Germany., Knudsen L; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany., Janciauskiene SM; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany., Werlein C; Institute for Pathology, Hannover Medical School, Hannover, Germany., Knoll M; Institute for Pathology, Hannover Medical School, Hannover, Germany., Engelhardt R; Institute for Pathology, Hannover Medical School, Hannover, Germany., Petzold-Mügge C; Institute for Pathology, Hannover Medical School, Hannover, Germany., Schupp JC; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany., Hoeper MM; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany., Gottlieb J; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany., Ius F; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Cardiac, Thoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany., Zardo P; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Cardiac, Thoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany., Lindenberg M; Institute for Medical Microbiology, Hannover Medical School, Hannover, Germany., Riehle C; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany., Neubert L; Institute for Pathology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany., Kamp JC; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.
Source: Respiratory research [Respir Res] 2026 Mar 07; Vol. 27 (1). Date of Electronic Publication: 2026 Mar 07.
Publication Type: Journal Article
Journal Info: Publisher: BioMed Central Ltd Country of Publication: England NLM ID: 101090633 Publication Model: Electronic Cited Medium: Internet ISSN: 1465-993X (Electronic) Linking ISSN: 14659921 NLM ISO Abbreviation: Respir Res Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Optimized culture of primary human alveolar type II cell-derived 3D organoids from fibrotic lung tissue with phenotypic and metabolic profiling.
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  Data: <searchLink fieldCode="AU" term="%22Schröder+LJ%22">Schröder LJ</searchLink>; Institute for Pathology, Hannover Medical School, Hannover, Germany. Schroeder.lara-jasmin@mh-hannover.de.; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany. Schroeder.lara-jasmin@mh-hannover.de.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany. Schroeder.lara-jasmin@mh-hannover.de.<br /><searchLink fieldCode="AU" term="%22Rückoldt+J%22">Rückoldt J</searchLink>; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Schubert+S%22">Schubert S</searchLink>; Institute for Pathology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Knudsen+L%22">Knudsen L</searchLink>; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Janciauskiene+SM%22">Janciauskiene SM</searchLink>; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Werlein+C%22">Werlein C</searchLink>; Institute for Pathology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Knoll+M%22">Knoll M</searchLink>; Institute for Pathology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Engelhardt+R%22">Engelhardt R</searchLink>; Institute for Pathology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Petzold-Mügge+C%22">Petzold-Mügge C</searchLink>; Institute for Pathology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Schupp+JC%22">Schupp JC</searchLink>; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Hoeper+MM%22">Hoeper MM</searchLink>; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Gottlieb+J%22">Gottlieb J</searchLink>; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Ius+F%22">Ius F</searchLink>; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Cardiac, Thoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Zardo+P%22">Zardo P</searchLink>; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Cardiac, Thoracic, Transplant and Vascular Surgery, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Lindenberg+M%22">Lindenberg M</searchLink>; Institute for Medical Microbiology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Riehle+C%22">Riehle C</searchLink>; Department of Cardiology and Angiology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Neubert+L%22">Neubert L</searchLink>; Institute for Pathology, Hannover Medical School, Hannover, Germany.; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Kamp+JC%22">Kamp JC</searchLink>; German Center for Lung Research (DZL), Biomedical Research in End-Stage and Obstructive Lung Disease Hanover (BREATH), Hannover, Germany.; Department of Respiratory Medicine and Infectious Diseases, Hannover Medical School, Hannover, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101090633%22">Respiratory research</searchLink> [Respir Res] 2026 Mar 07; Vol. 27 (1). <i>Date of Electronic Publication: </i>2026 Mar 07.
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              Text: 2026 Mar 07
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