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Immune biomarkers predicting response to G-CSF in acute-on-chronic liver failure: results from a GRAFT trial sub-study.

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Title: Immune biomarkers predicting response to G-CSF in acute-on-chronic liver failure: results from a GRAFT trial sub-study.
Authors: Splith K; Department of General, Visceral and Transplant Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. splith.katrin@mh-hannover.de.; Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinik, Charité-Universitätsmedizin Berlin, Berlin, Germany. splith.katrin@mh-hannover.de., Berndt N; Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinik, Charité-Universitätsmedizin Berlin, Berlin, Germany., Haber PK; Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinik, Charité-Universitätsmedizin Berlin, Berlin, Germany., Wabitsch S; Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinik, Charité-Universitätsmedizin Berlin, Berlin, Germany., Feldbrügge L; Department of General, Visceral and Transplant Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinik, Charité-Universitätsmedizin Berlin, Berlin, Germany., Herber A; Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany., Franke A; Clinical Trial Centre (ZKS) Leipzig, Faculty of Medicine, University Leipzig, Leipzig, Germany., Schmiedeknecht A; Clinical Trial Centre (ZKS) Leipzig, Faculty of Medicine, University Leipzig, Leipzig, Germany., Mengwasser J; Department of General, Visceral and Transplant Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinik, Charité-Universitätsmedizin Berlin, Berlin, Germany., Bruns T; Department of Medicine III, Aachen University Hospital, Aachen, Germany.; Clinic for Internal Medicine IV, University Hospital Jena, Jena, Germany., Reuken PA; Clinic for Internal Medicine IV, University Hospital Jena, Jena, Germany., Goeser T; Clinic for Gastroenterology and Hepatology, University Hospital Cologne, Cologne, Germany., Berg C; Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany., Wedemeyer H; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany., Chang J; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany., Mueller T; Department of Hepatology and Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Aehling N; Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany., Lammert F; Department of Medicine II, Saarland University Medical Center, Homburg, Germany.; Health Sciences, Hannover Medical School (MHH), Hannover, Germany., Galle PR; Department of Internal Medicine, University Medical Center Mainz, Mainz, Germany., Jiang ZG; Liver Clinic, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA., Robson SC; Liver Clinic, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Center for Inflammation Research, Beth Israel Deaconess Medical Center, Boston, MA, USA., Engelmann C; Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.; Department of Hepatology and Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany., Berg T; Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany., Schmelzle M; Department of General, Visceral and Transplant Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinik, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Source: Hepatology international [Hepatol Int] 2026 Jun; Vol. 20 (3), pp. 852-863. Date of Electronic Publication: 2026 Mar 07.
Publication Type: Journal Article; Multicenter Study; Randomized Controlled Trial
Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 101304009 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-0541 (Electronic) Linking ISSN: 19360533 NLM ISO Abbreviation: Hepatol Int Subsets: MEDLINE
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  Data: Immune biomarkers predicting response to G-CSF in acute-on-chronic liver failure: results from a GRAFT trial sub-study.
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  Data: <searchLink fieldCode="AU" term="%22Splith+K%22">Splith K</searchLink>; Department of General, Visceral and Transplant Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. splith.katrin@mh-hannover.de.; Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinik, Charité-Universitätsmedizin Berlin, Berlin, Germany. splith.katrin@mh-hannover.de.<br /><searchLink fieldCode="AU" term="%22Berndt+N%22">Berndt N</searchLink>; Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinik, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Haber+PK%22">Haber PK</searchLink>; Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinik, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Wabitsch+S%22">Wabitsch S</searchLink>; Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinik, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Feldbrügge+L%22">Feldbrügge L</searchLink>; Department of General, Visceral and Transplant Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinik, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Herber+A%22">Herber A</searchLink>; Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Franke+A%22">Franke A</searchLink>; Clinical Trial Centre (ZKS) Leipzig, Faculty of Medicine, University Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Schmiedeknecht+A%22">Schmiedeknecht A</searchLink>; Clinical Trial Centre (ZKS) Leipzig, Faculty of Medicine, University Leipzig, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Mengwasser+J%22">Mengwasser J</searchLink>; Department of General, Visceral and Transplant Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinik, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Bruns+T%22">Bruns T</searchLink>; Department of Medicine III, Aachen University Hospital, Aachen, Germany.; Clinic for Internal Medicine IV, University Hospital Jena, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Reuken+PA%22">Reuken PA</searchLink>; Clinic for Internal Medicine IV, University Hospital Jena, Jena, Germany.<br /><searchLink fieldCode="AU" term="%22Goeser+T%22">Goeser T</searchLink>; Clinic for Gastroenterology and Hepatology, University Hospital Cologne, Cologne, Germany.<br /><searchLink fieldCode="AU" term="%22Berg+C%22">Berg C</searchLink>; Department of Internal Medicine I, University Hospital Tübingen, Tübingen, Germany.<br /><searchLink fieldCode="AU" term="%22Wedemeyer+H%22">Wedemeyer H</searchLink>; Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School, Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Chang+J%22">Chang J</searchLink>; Department of Internal Medicine I, University Hospital Bonn, Bonn, Germany.<br /><searchLink fieldCode="AU" term="%22Mueller+T%22">Mueller T</searchLink>; Department of Hepatology and Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Aehling+N%22">Aehling N</searchLink>; Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Lammert+F%22">Lammert F</searchLink>; Department of Medicine II, Saarland University Medical Center, Homburg, Germany.; Health Sciences, Hannover Medical School (MHH), Hannover, Germany.<br /><searchLink fieldCode="AU" term="%22Galle+PR%22">Galle PR</searchLink>; Department of Internal Medicine, University Medical Center Mainz, Mainz, Germany.<br /><searchLink fieldCode="AU" term="%22Jiang+ZG%22">Jiang ZG</searchLink>; Liver Clinic, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Robson+SC%22">Robson SC</searchLink>; Liver Clinic, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.; Department of Anesthesia, Critical Care and Pain Medicine, Center for Inflammation Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.<br /><searchLink fieldCode="AU" term="%22Engelmann+C%22">Engelmann C</searchLink>; Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.; Department of Hepatology and Gastroenterology, Charité-Universitätsmedizin Berlin, Berlin, Germany.<br /><searchLink fieldCode="AU" term="%22Berg+T%22">Berg T</searchLink>; Division of Hepatology, Department of Medicine II, Leipzig University Medical Center, Leipzig, Germany.<br /><searchLink fieldCode="AU" term="%22Schmelzle+M%22">Schmelzle M</searchLink>; Department of General, Visceral and Transplant Surgery, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.; Department of Surgery, Campus Charité Mitte | Campus Virchow-Klinik, Charité-Universitätsmedizin Berlin, Berlin, Germany.
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  Data: <searchLink fieldCode="JN" term="%22101304009%22">Hepatology international</searchLink> [Hepatol Int] 2026 Jun; Vol. 20 (3), pp. 852-863. <i>Date of Electronic Publication: </i>2026 Mar 07.
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