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Accelerated discovery of highly active enzyme nanohybrids with parallelized Bayesian optimization in hybrid space.

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Title: Accelerated discovery of highly active enzyme nanohybrids with parallelized Bayesian optimization in hybrid space.
Authors: Liu Y; Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, China.; Synthera Biotechnology Co. Ltd., Shenzhen, China., Hu H; The State Key Laboratory of Chemical Engineering and Low-carbon Technology, Department of Chemical Engineering, Tsinghua University, Beijing, China., Han Y; The State Key Laboratory of Chemical Engineering and Low-carbon Technology, Department of Chemical Engineering, Tsinghua University, Beijing, China., Deon Chon JS; Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, China., Lo CL; Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, China., Chen Z; Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, China., Zhang Z; Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, China., Yuan Z; The State Key Laboratory of Chemical Engineering and Low-carbon Technology, Department of Chemical Engineering, Tsinghua University, Beijing, China. zhihongyuan@mail.tsinghua.edu.cn., Ge J; Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, China. junge@mail.tsinghua.edu.cn.; State Key Laboratory of Green Biomanufacturing, Beijing, China. junge@mail.tsinghua.edu.cn.
Source: Nature communications [Nat Commun] 2026 Mar 07; Vol. 17 (1). Date of Electronic Publication: 2026 Mar 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Liu+Y%22">Liu Y</searchLink>; Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, China.; Synthera Biotechnology Co. Ltd., Shenzhen, China.<br /><searchLink fieldCode="AU" term="%22Hu+H%22">Hu H</searchLink>; The State Key Laboratory of Chemical Engineering and Low-carbon Technology, Department of Chemical Engineering, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Han+Y%22">Han Y</searchLink>; The State Key Laboratory of Chemical Engineering and Low-carbon Technology, Department of Chemical Engineering, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Deon+Chon+JS%22">Deon Chon JS</searchLink>; Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Lo+CL%22">Lo CL</searchLink>; Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Chen+Z%22">Chen Z</searchLink>; Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Zhang+Z%22">Zhang Z</searchLink>; Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, China.<br /><searchLink fieldCode="AU" term="%22Yuan+Z%22">Yuan Z</searchLink>; The State Key Laboratory of Chemical Engineering and Low-carbon Technology, Department of Chemical Engineering, Tsinghua University, Beijing, China. zhihongyuan@mail.tsinghua.edu.cn.<br /><searchLink fieldCode="AU" term="%22Ge+J%22">Ge J</searchLink>; Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing, China. junge@mail.tsinghua.edu.cn.; State Key Laboratory of Green Biomanufacturing, Beijing, China. junge@mail.tsinghua.edu.cn.
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              Text: 2026 Mar 07
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