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Correction of eIF4E overactivation rescues translatome imbalance and core ASD-like behaviors in valproic acid-induced offspring mice.

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Title: Correction of eIF4E overactivation rescues translatome imbalance and core ASD-like behaviors in valproic acid-induced offspring mice.
Authors: Huang M; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China.; Medical College, Jiaying University, Meizhou, 514031, Guangdong, China.; Guangdong Province Key Laboratory of Brain Function and Disease, School of Medicine, Sun Yat-sen University, Shenzhen, 518107, China., Ye H; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China., Xu Y; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China., Xie J; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China., Wang X; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China., Luo Y; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China., Liu P; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China., Ma X; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China., Zhang S; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China., Jiang B; Medical College, Jiaying University, Meizhou, 514031, Guangdong, China.; Guangdong Province Key Laboratory of Brain Function and Disease, School of Medicine, Sun Yat-sen University, Shenzhen, 518107, China., Ye WC; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China. chywc@aliyun.com.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China. chywc@aliyun.com., Peng Y; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China. pengyinghui@foxmail.com.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China. pengyinghui@foxmail.com., Shi L; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China. t_shilei@jnu.edu.cn.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China. t_shilei@jnu.edu.cn.
Source: Molecular psychiatry [Mol Psychiatry] 2026 Jul; Vol. 31 (7), pp. 3987-4005. Date of Electronic Publication: 2026 Mar 07.
Publication Type: Journal Article
Journal Info: Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Correction of eIF4E overactivation rescues translatome imbalance and core ASD-like behaviors in valproic acid-induced offspring mice.
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  Data: <searchLink fieldCode="AU" term="%22Huang+M%22">Huang M</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China.; Medical College, Jiaying University, Meizhou, 514031, Guangdong, China.; Guangdong Province Key Laboratory of Brain Function and Disease, School of Medicine, Sun Yat-sen University, Shenzhen, 518107, China.<br /><searchLink fieldCode="AU" term="%22Ye+H%22">Ye H</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Xu+Y%22">Xu Y</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Xie+J%22">Xie J</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Wang+X%22">Wang X</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Luo+Y%22">Luo Y</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Liu+P%22">Liu P</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Ma+X%22">Ma X</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Zhang+S%22">Zhang S</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China.<br /><searchLink fieldCode="AU" term="%22Jiang+B%22">Jiang B</searchLink>; Medical College, Jiaying University, Meizhou, 514031, Guangdong, China.; Guangdong Province Key Laboratory of Brain Function and Disease, School of Medicine, Sun Yat-sen University, Shenzhen, 518107, China.<br /><searchLink fieldCode="AU" term="%22Ye+WC%22">Ye WC</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China. chywc@aliyun.com.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China. chywc@aliyun.com.<br /><searchLink fieldCode="AU" term="%22Peng+Y%22">Peng Y</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China. pengyinghui@foxmail.com.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China. pengyinghui@foxmail.com.<br /><searchLink fieldCode="AU" term="%22Shi+L%22">Shi L</searchLink>; State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and Discovery of Innovative Drugs, Guangzhou, 510632, China. t_shilei@jnu.edu.cn.; JNU-HKUST Joint Laboratory for Neuroscience and Innovative Drug Research, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Guangdong Hong Kong-Macau Joint Laboratory for Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, 510632, Guangdong, China. t_shilei@jnu.edu.cn.
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  Data: <searchLink fieldCode="JN" term="%229607835%22">Molecular psychiatry</searchLink> [Mol Psychiatry] 2026 Jul; Vol. 31 (7), pp. 3987-4005. <i>Date of Electronic Publication: </i>2026 Mar 07.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Publishing+Group+Specialist+Journals%22">Nature Publishing Group Specialist Journals </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9607835 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1476-5578 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2213594184%22">13594184 </searchLink><i>NLM ISO Abbreviation: </i>Mol Psychiatry <i>Subsets: </i>MEDLINE
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RecordInfo BibRecord:
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        Value: 10.1038/s41380-026-03517-3
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        Text: English
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      – TitleFull: Correction of eIF4E overactivation rescues translatome imbalance and core ASD-like behaviors in valproic acid-induced offspring mice.
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              M: 07
              Text: 2026 Jul
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              Y: 2026
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