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Safety, tolerability, and preliminary efficacy of seltorexant versus quetiapine extended release as adjunctive therapy in major depressive disorder: a randomized, flexible-dose, 6-month, parallel-group, exploratory study.

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Title: Safety, tolerability, and preliminary efficacy of seltorexant versus quetiapine extended release as adjunctive therapy in major depressive disorder: a randomized, flexible-dose, 6-month, parallel-group, exploratory study.
Authors: Pinter C; Neuroscience Clinical Development, Johnson & Johnson, Titusville, NJ, United States., Thase ME; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Mood & Anxiety Disorders Section, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, United States., McIntyre RS; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada., Cooper K; Department of Statistics & Decision Sciences, Johnson & Johnson, Spring House, PA, United States., Xu H; Department of Statistics & Decision Sciences, Johnson & Johnson, Titusville, NJ, United States., Pandina G; Neuroscience Clinical Development, Johnson & Johnson, Titusville, NJ, United States., Savitz A; Neuroscience Clinical Development, Johnson & Johnson, Titusville, NJ, United States., Drevets WC; Neuroscience Clinical Development, Johnson & Johnson, San Diego, CA, United States.
Source: The international journal of neuropsychopharmacology [Int J Neuropsychopharmacol] 2026 Apr 06; Vol. 29 (4).
Publication Type: Journal Article; Randomized Controlled Trial; Multicenter Study; Clinical Trial, Phase II; Comparative Study
Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9815893 Publication Model: Print Cited Medium: Internet ISSN: 1469-5111 (Electronic) Linking ISSN: 14611457 NLM ISO Abbreviation: Int J Neuropsychopharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Safety, tolerability, and preliminary efficacy of seltorexant versus quetiapine extended release as adjunctive therapy in major depressive disorder: a randomized, flexible-dose, 6-month, parallel-group, exploratory study.
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  Data: <searchLink fieldCode="AU" term="%22Pinter+C%22">Pinter C</searchLink>; Neuroscience Clinical Development, Johnson & Johnson, Titusville, NJ, United States.<br /><searchLink fieldCode="AU" term="%22Thase+ME%22">Thase ME</searchLink>; Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States.; Mood & Anxiety Disorders Section, Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, PA, United States.<br /><searchLink fieldCode="AU" term="%22McIntyre+RS%22">McIntyre RS</searchLink>; Department of Psychiatry, University of Toronto, Toronto, ON, Canada.; Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.<br /><searchLink fieldCode="AU" term="%22Cooper+K%22">Cooper K</searchLink>; Department of Statistics & Decision Sciences, Johnson & Johnson, Spring House, PA, United States.<br /><searchLink fieldCode="AU" term="%22Xu+H%22">Xu H</searchLink>; Department of Statistics & Decision Sciences, Johnson & Johnson, Titusville, NJ, United States.<br /><searchLink fieldCode="AU" term="%22Pandina+G%22">Pandina G</searchLink>; Neuroscience Clinical Development, Johnson & Johnson, Titusville, NJ, United States.<br /><searchLink fieldCode="AU" term="%22Savitz+A%22">Savitz A</searchLink>; Neuroscience Clinical Development, Johnson & Johnson, Titusville, NJ, United States.<br /><searchLink fieldCode="AU" term="%22Drevets+WC%22">Drevets WC</searchLink>; Neuroscience Clinical Development, Johnson & Johnson, San Diego, CA, United States.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Oxford+University+Press%22">Oxford University Press </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9815893 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1469-5111 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214611457%22">14611457 </searchLink><i>NLM ISO Abbreviation: </i>Int J Neuropsychopharmacol <i>Subsets: </i>MEDLINE
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        Value: 10.1093/ijnp/pyag009
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              Text: 2026 Apr 06
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