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Impact of creatine supplementation on inflammation: evidence from a systematic review and meta-analysis of randomized double-blind placebo trials.

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Title: Impact of creatine supplementation on inflammation: evidence from a systematic review and meta-analysis of randomized double-blind placebo trials.
Authors: de Camargo KMR; Systematic Reviews Center for Cardiovascular and Metabolic Health, School of Philosophy and Sciences, São Paulo State University, Marília, SP, Brazil., Bruna-Mejías A; Escuela de Medicina, Facultad de Medicina, Universidad Andres Bello, Santiago, Chile.; Departamento de Ciencias y Geografia, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Valparaiso, Chile., Valenzuela-Fuenzalida JJ; Departamento de Ciencias Químicas y Biológicas, Facultad de Ciencias de la Salud, Universidad Bernardo O'Higgins, Santiago, Chile., Gonzaga LA; Systematic Reviews Center for Cardiovascular and Metabolic Health, School of Philosophy and Sciences, São Paulo State University, Marília, SP, Brazil., Barbalho SM; Postgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Marília (UNIMAR), Marília, São Paulo, Brazil.; Department of Biochemistry and Nutrition, School of Food and Technology of Marilia (FATEC), Marília, São Paulo, Brazil.; UNIMAR Charity Hospital, Universidade de Marilia (UNIMAR), Marília, São Paulo, Brazil., Barroca AL; Systematic Reviews Center for Cardiovascular and Metabolic Health, School of Philosophy and Sciences, São Paulo State University, Marília, SP, Brazil., Porto AA; Systematic Reviews Center for Cardiovascular and Metabolic Health, School of Philosophy and Sciences, São Paulo State University, Marília, SP, Brazil., Raimundo RD; Laboratorio de Delineamento de Estudos e Escrita Científica, Centro Universitario FMABC, Santo Andre, SP, Brazil., de Abreu LC; Department of Public Health, University of Limerick, Limerick, IE, Ireland.; Department of Nutrition, Federal University of Vitoria, Vitoria, ES, Brazil., Valenti VE; Systematic Reviews Center for Cardiovascular and Metabolic Health, School of Philosophy and Sciences, São Paulo State University, Marília, SP, Brazil.
Source: Frontiers in immunology [Front Immunol] 2026 Feb 19; Vol. 17, pp. 1743603. Date of Electronic Publication: 2026 Feb 19 (Print Publication: 2026).
Publication Type: Journal Article; Systematic Review; Meta-Analysis
Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Impact of creatine supplementation on inflammation: evidence from a systematic review and meta-analysis of randomized double-blind placebo trials.
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  Data: <searchLink fieldCode="AU" term="%22de+Camargo+KMR%22">de Camargo KMR</searchLink>; Systematic Reviews Center for Cardiovascular and Metabolic Health, School of Philosophy and Sciences, São Paulo State University, Marília, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Bruna-Mejías+A%22">Bruna-Mejías A</searchLink>; Escuela de Medicina, Facultad de Medicina, Universidad Andres Bello, Santiago, Chile.; Departamento de Ciencias y Geografia, Facultad de Ciencias Naturales y Exactas, Universidad de Playa Ancha, Valparaiso, Chile.<br /><searchLink fieldCode="AU" term="%22Valenzuela-Fuenzalida+JJ%22">Valenzuela-Fuenzalida JJ</searchLink>; Departamento de Ciencias Químicas y Biológicas, Facultad de Ciencias de la Salud, Universidad Bernardo O'Higgins, Santiago, Chile.<br /><searchLink fieldCode="AU" term="%22Gonzaga+LA%22">Gonzaga LA</searchLink>; Systematic Reviews Center for Cardiovascular and Metabolic Health, School of Philosophy and Sciences, São Paulo State University, Marília, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Barbalho+SM%22">Barbalho SM</searchLink>; Postgraduate Program in Structural and Functional Interactions in Rehabilitation, School of Medicine, Universidade de Marília (UNIMAR), Marília, São Paulo, Brazil.; Department of Biochemistry and Nutrition, School of Food and Technology of Marilia (FATEC), Marília, São Paulo, Brazil.; UNIMAR Charity Hospital, Universidade de Marilia (UNIMAR), Marília, São Paulo, Brazil.<br /><searchLink fieldCode="AU" term="%22Barroca+AL%22">Barroca AL</searchLink>; Systematic Reviews Center for Cardiovascular and Metabolic Health, School of Philosophy and Sciences, São Paulo State University, Marília, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Porto+AA%22">Porto AA</searchLink>; Systematic Reviews Center for Cardiovascular and Metabolic Health, School of Philosophy and Sciences, São Paulo State University, Marília, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22Raimundo+RD%22">Raimundo RD</searchLink>; Laboratorio de Delineamento de Estudos e Escrita Científica, Centro Universitario FMABC, Santo Andre, SP, Brazil.<br /><searchLink fieldCode="AU" term="%22de+Abreu+LC%22">de Abreu LC</searchLink>; Department of Public Health, University of Limerick, Limerick, IE, Ireland.; Department of Nutrition, Federal University of Vitoria, Vitoria, ES, Brazil.<br /><searchLink fieldCode="AU" term="%22Valenti+VE%22">Valenti VE</searchLink>; Systematic Reviews Center for Cardiovascular and Metabolic Health, School of Philosophy and Sciences, São Paulo State University, Marília, SP, Brazil.
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  Data: <searchLink fieldCode="JN" term="%22101560960%22">Frontiers in immunology</searchLink> [Front Immunol] 2026 Feb 19; Vol. 17, pp. 1743603. <i>Date of Electronic Publication: </i>2026 Feb 19 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Frontiers+Research+Foundation]%22">Frontiers Research Foundation] </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>101560960 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1664-3224 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2216643224%22">16643224 </searchLink><i>NLM ISO Abbreviation: </i>Front Immunol <i>Subsets: </i>MEDLINE
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