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A prognostic 19-gene signature and LBP-mediated immune dysregulation define the tumor microenvironment in poor-prognosis KIRC.

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Title: A prognostic 19-gene signature and LBP-mediated immune dysregulation define the tumor microenvironment in poor-prognosis KIRC.
Authors: Chen CH; Department of Medical Research, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan, ROC.; Department of Medical Research, Hsinchu Municipal MacKay Children's Hospital, Hsinchu City 30068, Taiwan, ROC., Huang HH; Industrial Development Graduate Program of College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu City 30068, Taiwan, ROC., Weng TH; Department of Dermatology, MacKay Memorial Hospital, Taipei City 10449, Taiwan, ROC., Kuo TW; Department of Biological Science and Technology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu City 30068, Taiwan, ROC., Ho NC; Department of Biological Science and Technology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu City 30068, Taiwan, ROC., Huang KY; Department of Medical Research, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan, ROC.; Department of Medical Research, Hsinchu Municipal MacKay Children's Hospital, Hsinchu City 30068, Taiwan, ROC.; Department of Medicine, MacKay Medical College, New Taipei City 25245, Taiwan, ROC.; Institute of Biomedical Sciences, MacKay Medical College, New Taipei City 25245, Taiwan, ROC., Kao HJ; Department of Medical Research, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan, ROC.; Department of Medical Research, Hsinchu Municipal MacKay Children's Hospital, Hsinchu City 30068, Taiwan, ROC., Yu CL; Department of Medical Research, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan, ROC.; Department of Medical Research, Hsinchu Municipal MacKay Children's Hospital, Hsinchu City 30068, Taiwan, ROC., Weng SL; Department of Biological Science and Technology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu City 30068, Taiwan, ROC.; Department of Medicine, MacKay Medical College, New Taipei City 25245, Taiwan, ROC.; Department of Obstetrics and Gynecology, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan, ROC.; Mackay Junior College of Medicine, Nursing and Management, Taipei City 11260, Taiwan, ROC.; Department of Obstetrics and Gynecology, Hsinchu Municipal MacKay Children's Hospital, Hsinchu City 30068, Taiwan, ROC., Liao KW; Department of Biological Science and Technology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu City 30068, Taiwan, ROC.; Institute of Molecular Medicine and Bioengineering, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu City 30068, Taiwan, ROC.; Center for Intelligent Drug Systems and Smart Bio-devices (IDS 2 B), National Yang Ming Chiao Tung University, Hsinchu City 30068, Taiwan, ROC.; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan City 70101, Taiwan, ROC.; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City 80708, Taiwan, ROC.; School of Dentistry, Kaohsiung Medical University, Kaohsiung City 80708, Taiwan, ROC.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung City 80708, Taiwan, ROC.
Source: International journal of medical sciences [Int J Med Sci] 2026 Jan 30; Vol. 23 (3), pp. 824-842. Date of Electronic Publication: 2026 Jan 30 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Publisher Country of Publication: Australia NLM ID: 101213954 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-1907 (Electronic) Linking ISSN: 14491907 NLM ISO Abbreviation: Int J Med Sci Subsets: MEDLINE
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  Data: A prognostic 19-gene signature and LBP-mediated immune dysregulation define the tumor microenvironment in poor-prognosis KIRC.
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  Data: <searchLink fieldCode="AU" term="%22Chen+CH%22">Chen CH</searchLink>; Department of Medical Research, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan, ROC.; Department of Medical Research, Hsinchu Municipal MacKay Children's Hospital, Hsinchu City 30068, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Huang+HH%22">Huang HH</searchLink>; Industrial Development Graduate Program of College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu City 30068, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Weng+TH%22">Weng TH</searchLink>; Department of Dermatology, MacKay Memorial Hospital, Taipei City 10449, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Kuo+TW%22">Kuo TW</searchLink>; Department of Biological Science and Technology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu City 30068, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Ho+NC%22">Ho NC</searchLink>; Department of Biological Science and Technology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu City 30068, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Huang+KY%22">Huang KY</searchLink>; Department of Medical Research, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan, ROC.; Department of Medical Research, Hsinchu Municipal MacKay Children's Hospital, Hsinchu City 30068, Taiwan, ROC.; Department of Medicine, MacKay Medical College, New Taipei City 25245, Taiwan, ROC.; Institute of Biomedical Sciences, MacKay Medical College, New Taipei City 25245, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Kao+HJ%22">Kao HJ</searchLink>; Department of Medical Research, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan, ROC.; Department of Medical Research, Hsinchu Municipal MacKay Children's Hospital, Hsinchu City 30068, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Yu+CL%22">Yu CL</searchLink>; Department of Medical Research, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan, ROC.; Department of Medical Research, Hsinchu Municipal MacKay Children's Hospital, Hsinchu City 30068, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Weng+SL%22">Weng SL</searchLink>; Department of Biological Science and Technology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu City 30068, Taiwan, ROC.; Department of Medicine, MacKay Medical College, New Taipei City 25245, Taiwan, ROC.; Department of Obstetrics and Gynecology, Hsinchu MacKay Memorial Hospital, Hsinchu City 30071, Taiwan, ROC.; Mackay Junior College of Medicine, Nursing and Management, Taipei City 11260, Taiwan, ROC.; Department of Obstetrics and Gynecology, Hsinchu Municipal MacKay Children's Hospital, Hsinchu City 30068, Taiwan, ROC.<br /><searchLink fieldCode="AU" term="%22Liao+KW%22">Liao KW</searchLink>; Department of Biological Science and Technology, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu City 30068, Taiwan, ROC.; Institute of Molecular Medicine and Bioengineering, College of Engineering Bioscience, National Yang Ming Chiao Tung University, Hsinchu City 30068, Taiwan, ROC.; Center for Intelligent Drug Systems and Smart Bio-devices (IDS 2 B), National Yang Ming Chiao Tung University, Hsinchu City 30068, Taiwan, ROC.; Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Tainan City 70101, Taiwan, ROC.; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City 80708, Taiwan, ROC.; School of Dentistry, Kaohsiung Medical University, Kaohsiung City 80708, Taiwan, ROC.; Drug Development and Value Creation Research Center, Kaohsiung Medical University, Kaohsiung City 80708, Taiwan, ROC.
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  Data: <searchLink fieldCode="JN" term="%22101213954%22">International journal of medical sciences</searchLink> [Int J Med Sci] 2026 Jan 30; Vol. 23 (3), pp. 824-842. <i>Date of Electronic Publication: </i>2026 Jan 30 (<i>Print Publication: </i>2026).
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        Value: 10.7150/ijms.125505
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      – TitleFull: A prognostic 19-gene signature and LBP-mediated immune dysregulation define the tumor microenvironment in poor-prognosis KIRC.
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              Text: 2026 Jan 30
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