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ARID1A deficiency activates OSM-STAT3 axis in endometrial cancer, creating vulnerability to JAK/STAT3 inhibition.

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Title: ARID1A deficiency activates OSM-STAT3 axis in endometrial cancer, creating vulnerability to JAK/STAT3 inhibition.
Authors: Chen LJ; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China., Shi C; Nanjing Key Laboratory of Female Fertility Preservation and Restoration, Nanjing Women and Children's Healthcare Institute, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, 210004, China., Yang EJ; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China., Ren G; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, Guangdong, 518055, China., Tao S; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, Guangdong, 518055, China., Pu Y; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China., Zhang X; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China., Shen X; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China., Wu C; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China., Shim JS; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.; MOE Frontiers Science Centre for Precision Oncology, University of Macau, Taipa, Macau SAR, China.
Source: International journal of biological sciences [Int J Biol Sci] 2026 Feb 11; Vol. 22 (5), pp. 2638-2653. Date of Electronic Publication: 2026 Feb 11 (Print Publication: 2026).
Publication Type: Journal Article
Journal Info: Publisher: Ivyspring International Country of Publication: Australia NLM ID: 101235568 Publication Model: eCollection Cited Medium: Internet ISSN: 1449-2288 (Electronic) Linking ISSN: 14492288 NLM ISO Abbreviation: Int J Biol Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: ARID1A deficiency activates OSM-STAT3 axis in endometrial cancer, creating vulnerability to JAK/STAT3 inhibition.
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  Data: <searchLink fieldCode="AU" term="%22Chen+LJ%22">Chen LJ</searchLink>; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.<br /><searchLink fieldCode="AU" term="%22Shi+C%22">Shi C</searchLink>; Nanjing Key Laboratory of Female Fertility Preservation and Restoration, Nanjing Women and Children's Healthcare Institute, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, 210004, China.<br /><searchLink fieldCode="AU" term="%22Yang+EJ%22">Yang EJ</searchLink>; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.<br /><searchLink fieldCode="AU" term="%22Ren+G%22">Ren G</searchLink>; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, Guangdong, 518055, China.<br /><searchLink fieldCode="AU" term="%22Tao+S%22">Tao S</searchLink>; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.; Institute of Cancer Research, Shenzhen Bay Laboratory, Shenzhen, Guangdong, 518055, China.<br /><searchLink fieldCode="AU" term="%22Pu+Y%22">Pu Y</searchLink>; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.<br /><searchLink fieldCode="AU" term="%22Zhang+X%22">Zhang X</searchLink>; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.<br /><searchLink fieldCode="AU" term="%22Shen+X%22">Shen X</searchLink>; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.<br /><searchLink fieldCode="AU" term="%22Wu+C%22">Wu C</searchLink>; Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China.<br /><searchLink fieldCode="AU" term="%22Shim+JS%22">Shim JS</searchLink>; Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau SAR, China.; MOE Frontiers Science Centre for Precision Oncology, University of Macau, Taipa, Macau SAR, China.
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  Data: <searchLink fieldCode="JN" term="%22101235568%22">International journal of biological sciences</searchLink> [Int J Biol Sci] 2026 Feb 11; Vol. 22 (5), pp. 2638-2653. <i>Date of Electronic Publication: </i>2026 Feb 11 (<i>Print Publication: </i>2026).
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Ivyspring+International%22">Ivyspring International </searchLink><i>Country of Publication: </i>Australia <i>NLM ID: </i>101235568 <i>Publication Model: </i>eCollection <i>Cited Medium: </i>Internet <i>ISSN: </i>1449-2288 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2214492288%22">14492288 </searchLink><i>NLM ISO Abbreviation: </i>Int J Biol Sci <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=41800254
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        Value: 10.7150/ijbs.129142
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              Text: 2026 Feb 11
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