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A yeast synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation.

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Title: A yeast synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation.
Authors: Palou R; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada., van der Sloot AM; Mila - Québec Artificial Intelligence Institute, Montréal, QC H2S 3H1, Canada.; Université de Montréal, Département d'informatique et de recherche opérationnelle, Montréal, QC H3C 3J7, Canada., Fiebig AA; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada., Zangara MT; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada., Sangwan N; Microbial Sequencing and Analytics Resource (MSAAR) Facility, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA.; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.; David Braley Center for Antibiotic Discovery, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada., Sánchez-Osuna M; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada., Ilyas B; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada., Zubyk H; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.; David Braley Center for Antibiotic Discovery, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada., Cook M; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.; David Braley Center for Antibiotic Discovery, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada., Wright GD; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.; David Braley Center for Antibiotic Discovery, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada., Coombes BK; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.; David Braley Center for Antibiotic Discovery, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada., Tyers M; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
Source: Disease models & mechanisms [Dis Model Mech] 2026 Feb 01; Vol. 19 (2). Date of Electronic Publication: 2026 Mar 09.
Publication Type: Journal Article
Journal Info: Publisher: Company of Biologists Ltd Country of Publication: England NLM ID: 101483332 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1754-8411 (Electronic) Linking ISSN: 17548403 NLM ISO Abbreviation: Dis Model Mech Subsets: MEDLINE
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  Data: A yeast synthetic biotic platform for delivery of therapeutic nanobodies to ameliorate gastrointestinal inflammation.
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  Data: <searchLink fieldCode="AU" term="%22Palou+R%22">Palou R</searchLink>; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22van+der+Sloot+AM%22">van der Sloot AM</searchLink>; Mila - Québec Artificial Intelligence Institute, Montréal, QC H2S 3H1, Canada.; Université de Montréal, Département d'informatique et de recherche opérationnelle, Montréal, QC H3C 3J7, Canada.<br /><searchLink fieldCode="AU" term="%22Fiebig+AA%22">Fiebig AA</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Zangara+MT%22">Zangara MT</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Sangwan+N%22">Sangwan N</searchLink>; Microbial Sequencing and Analytics Resource (MSAAR) Facility, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44106, USA.; Center for Microbiome and Human Health, Cleveland Clinic, Cleveland, OH 44106, USA.; David Braley Center for Antibiotic Discovery, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Sánchez-Osuna+M%22">Sánchez-Osuna M</searchLink>; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.<br /><searchLink fieldCode="AU" term="%22Ilyas+B%22">Ilyas B</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Zubyk+H%22">Zubyk H</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.; David Braley Center for Antibiotic Discovery, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Cook+M%22">Cook M</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.; David Braley Center for Antibiotic Discovery, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Wright+GD%22">Wright GD</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.; David Braley Center for Antibiotic Discovery, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Coombes+BK%22">Coombes BK</searchLink>; Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L8S 4K1, Canada.; David Braley Center for Antibiotic Discovery, Michael G. DeGroote Institute for Infectious Disease Research, McMaster University, Hamilton, ON L8S 4K1, Canada.<br /><searchLink fieldCode="AU" term="%22Tyers+M%22">Tyers M</searchLink>; Program in Molecular Medicine, The Hospital for Sick Children Research Institute, Toronto, ON M5G 0A4, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada.
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              Text: 2026 Feb 01
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