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Non-covalent proteasome inhibitor PI1840 suppresses osteoclastogenesis and prevents LPS-induced osteolysis in mice.

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Title: Non-covalent proteasome inhibitor PI1840 suppresses osteoclastogenesis and prevents LPS-induced osteolysis in mice.
Authors: Xia Y; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China., Zhao F; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China., Dang C; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China., Bai J; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China., Li Y; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China., Yang J; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China., You Q; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China., Tang Q; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China., Dou W; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China., Liu M; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China. meiliunj@163.com.
Source: Inflammopharmacology [Inflammopharmacology] 2026 Apr; Vol. 34 (4), pp. 2579-2591. Date of Electronic Publication: 2026 Mar 09.
Publication Type: Journal Article
Journal Info: Publisher: Birkhäuser Country of Publication: Switzerland NLM ID: 9112626 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-5608 (Electronic) Linking ISSN: 09254692 NLM ISO Abbreviation: Inflammopharmacology Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Non-covalent proteasome inhibitor PI1840 suppresses osteoclastogenesis and prevents LPS-induced osteolysis in mice.
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  Data: <searchLink fieldCode="AU" term="%22Xia+Y%22">Xia Y</searchLink>; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Zhao+F%22">Zhao F</searchLink>; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Dang+C%22">Dang C</searchLink>; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Bai+J%22">Bai J</searchLink>; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Li+Y%22">Li Y</searchLink>; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Yang+J%22">Yang J</searchLink>; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22You+Q%22">You Q</searchLink>; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Tang+Q%22">Tang Q</searchLink>; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Dou+W%22">Dou W</searchLink>; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China.<br /><searchLink fieldCode="AU" term="%22Liu+M%22">Liu M</searchLink>; Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, 210023, China. meiliunj@163.com.
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  Data: <searchLink fieldCode="JN" term="%229112626%22">Inflammopharmacology</searchLink> [Inflammopharmacology] 2026 Apr; Vol. 34 (4), pp. 2579-2591. <i>Date of Electronic Publication: </i>2026 Mar 09.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Birkhäuser%22">Birkhäuser </searchLink><i>Country of Publication: </i>Switzerland <i>NLM ID: </i>9112626 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1568-5608 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2209254692%22">09254692 </searchLink><i>NLM ISO Abbreviation: </i>Inflammopharmacology <i>Subsets: </i>MEDLINE
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        Value: 10.1007/s10787-026-02175-9
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      – Code: eng
        Text: English
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        StartPage: 2579
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      – TitleFull: Non-covalent proteasome inhibitor PI1840 suppresses osteoclastogenesis and prevents LPS-induced osteolysis in mice.
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              Text: 2026 Apr
              Type: published
              Y: 2026
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