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Targeting PRMTs Creates Vulnerability of DNA Double-Stand Break Repair Pathways, and Potentiates Chemotherapy Efficacy in TNBC.

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Title: Targeting PRMTs Creates Vulnerability of DNA Double-Stand Break Repair Pathways, and Potentiates Chemotherapy Efficacy in TNBC.
Authors: Thiebaut C; Université Claude Bernard Lyon 1, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France., Martinez S; Université Claude Bernard Lyon 1, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France., Pruvost L; Université Claude Bernard Lyon 1, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France., Eve L; Université Claude Bernard Lyon 1, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France., El-Botty R; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France., Sourd L; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France., Montaudon E; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France., Dahmani A; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France., Derrien H; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France., Sentis S; Université Claude Bernard Lyon 1, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France., Poulard C; Université Claude Bernard Lyon 1, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France., Marangoni E; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France., Trédan O; Université Claude Bernard Lyon 1, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; Oncology Department, Centre Leon Bérard, Lyon, France., Le Romancer M; Université Claude Bernard Lyon 1, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
Source: Cancer science [Cancer Sci] 2026 May; Vol. 117 (5), pp. 1273-1285. Date of Electronic Publication: 2026 Mar 09.
Publication Type: Journal Article
Journal Info: Publisher: Wiley Publishing on behalf of the Japanese Cancer Association Country of Publication: England NLM ID: 101168776 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1349-7006 (Electronic) Linking ISSN: 13479032 NLM ISO Abbreviation: Cancer Sci Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Targeting PRMTs Creates Vulnerability of DNA Double-Stand Break Repair Pathways, and Potentiates Chemotherapy Efficacy in TNBC.
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  Data: <searchLink fieldCode="AU" term="%22Thiebaut+C%22">Thiebaut C</searchLink>; Université Claude Bernard Lyon 1, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Martinez+S%22">Martinez S</searchLink>; Université Claude Bernard Lyon 1, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Pruvost+L%22">Pruvost L</searchLink>; Université Claude Bernard Lyon 1, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Eve+L%22">Eve L</searchLink>; Université Claude Bernard Lyon 1, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22El-Botty+R%22">El-Botty R</searchLink>; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Sourd+L%22">Sourd L</searchLink>; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Montaudon+E%22">Montaudon E</searchLink>; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Dahmani+A%22">Dahmani A</searchLink>; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Derrien+H%22">Derrien H</searchLink>; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Sentis+S%22">Sentis S</searchLink>; Université Claude Bernard Lyon 1, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Poulard+C%22">Poulard C</searchLink>; Université Claude Bernard Lyon 1, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Marangoni+E%22">Marangoni E</searchLink>; Laboratory of Preclinical Investigation, Translational Research Department, Institut Curie, PSL University, Paris, France.<br /><searchLink fieldCode="AU" term="%22Trédan+O%22">Trédan O</searchLink>; Université Claude Bernard Lyon 1, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; Oncology Department, Centre Leon Bérard, Lyon, France.<br /><searchLink fieldCode="AU" term="%22Le+Romancer+M%22">Le Romancer M</searchLink>; Université Claude Bernard Lyon 1, Lyon, France.; Inserm U1052, Centre de Recherche en Cancérologie de Lyon, Lyon, France.; CNRS UMR5286, Centre de Recherche en Cancérologie de Lyon, Lyon, France.
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  Data: <searchLink fieldCode="JN" term="%22101168776%22">Cancer science</searchLink> [Cancer Sci] 2026 May; Vol. 117 (5), pp. 1273-1285. <i>Date of Electronic Publication: </i>2026 Mar 09.
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